Clinical applicability of the Polygenic Risk Score for breast cancer risk prediction in familial cases.

Autor: Lakeman IMM; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., Rodríguez-Girondo MDM; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands., Lee A; Public Health and Primary Care, University of Cambridge Centre for Cancer Genetic Epidemiology, Cambridge, UK., Celosse N; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Braspenning ME; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., van Engelen K; Department of Human Genetics, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands., van de Beek I; Department of Human Genetics, Amsterdam UMC Locatie VUmc, Amsterdam, The Netherlands., van der Hout AH; Department of Clinical Genetics, University Medical Centre Groningen, Groningen, The Netherlands., Gómez García EB; Department of Clinical Genetics, Maastricht University Medical Centre+, Maastricht, The Netherlands., Mensenkamp AR; Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, The Netherlands., Ausems MGEM; Department of Medical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands., Hooning MJ; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands., Adank MA; Family Cancer Clinic, Antoni van Leeuwenhoek Netherlands Cancer Institute, Amsterdam, The Netherlands., Hollestelle A; Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, The Netherlands., Schmidt MK; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Division of Psychosocial Research and Epidemiology, Antoni van Leeuwenhoek Netherlands Cancer Institute, Amsterdam, The Netherlands., van Asperen CJ; Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands., Devilee P; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands p.devilee@lumc.nl.; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Journal of medical genetics [J Med Genet] 2023 Apr; Vol. 60 (4), pp. 327-336. Date of Electronic Publication: 2022 Sep 22.

Functional Categorization of BRCA1 Variants of Uncertain Clinical Significance in Homologous Recombination Repair Complementation Assays.

Autor: Bouwman P; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. j.jonkers@nki.nl p.bouwman@nki.nl., van der Heijden I; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., van der Gulden H; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., de Bruijn R; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.; Oncode Institute and Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Braspenning ME; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Moghadasi S; Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands., Wessels LFA; Oncode Institute and Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Vreeswijk MPG; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Jonkers J; Oncode Institute and Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands. j.jonkers@nki.nl p.bouwman@nki.nl.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2020 Sep 01; Vol. 26 (17), pp. 4559-4568. Date of Electronic Publication: 2020 Jun 16.