Serum iron levels and the risk of Parkinson Disease: a Mendelian randomization study

Autor: Pichler I, Del Greco M. F, Gögele M, Lill CM, Bertram L, Do CB, Eriksson N, Foroud T, Myers RH, PD GWAS Consortium, Nalls M, Keller MF, International Parkinson's Disease Genomics Consortium, Wellcome Trust Case Control Consortium 2, Benyamin B, Whitfield JB, Genetics of Iron Status Consortium, Pramstaller PP, Hicks AA, Thompson JR, Minelli C., Plagnol V, Hernandez DG, Sharma M, Sheerin UM, Saad M, Simón Sánchez J, Schulte C, Lesage S, Arepalli S, Barker R, Ben Shlomo Y, Berendse HW, Berg D, Bhatia K, de Bie RM, Biffi A, Bloem B, Bochdanovits Z, Bonin M, Bras JM, Brockmann K, Brooks J, Burn DJ, Charlesworth G, Chen H, Chinnery PF, Chong S, Clarke CE, Cookson MR, Cooper JM, Corvol JC, Counsell C, Damier P, Dartigues JF, Deloukas P, Deuschl G, Dexter DT, van Dijk KD, Dillman A, Durif F, Dürr A, Edkins S, Evans JR, Foltynie T, Gao J, Gardner M, Gibbs JR, Goate A, Gray E, Guerreiro R, Harris C, van Hilten JJ, Hofman A, Hollenbeck A, Holton J, Hu M, Huang X, Huber H, Hudson G, Hunt SE, Illig T, Lambert JC, Langford C, Lees A, Lichtner P, Limousin P, Lopez G, Lorenz D, McNeill A, Moorby C, Moore M, Morris HR, Morrison KE, Mudanohwo E, O'Sullivan SS, Pearson J, Perlmutter JS, Pollak P, Post B, Potter S, Ravina B, Revesz T, Riess O, Rivadeneira F, Rizzu P, Ryten M, Sawcer S, Schapira A, Scheffer H, Shaw K, Shoulson I, Sidransky E, Smith C, Spencer CC, Stockton JD, Strange A, Talbot K, Tanner CM, Tashakkori Ghanbaria A, Trabzuni D, Traynor BJ, Uitterlinden AG, Velseboer D, Vidailhet M, Walker R, van de Warrenburg B, Wickremaratchi M, Williams N, Williams Gray CH, Winder Rhodes S, Martinez M, Hardy J, Heutink P, Brice A, Gasser T, Singleton AB, Wood NW, Donnelly P, Barroso I, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Band G, Bellenguez C, Freeman C, Hellenthal G, Giannoulatou E, Pirinen M, Pearson R, Su Z, Vukcevic D, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Hammond N, Jayakumar A, McCann OT, Liddle J, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, McCarthy MI, Ouwehand WH, Radhakrishnan A, Sambrook J, Toniolo D, Camaschella C, Metspalu A, Esko T, Gieger C, Ried J, Meitinger T, Oexle K, Winkelmann J, Swinkels D, Vermeulen S, van Duijn C, Broer L, Beilby J, Hui J, Anderson D, Visscher P, Martin N., TRAGLIA, MICHELA

Publikováno v: Pichler, I, Del Greco, M F, Gögele, M, Lill, C M, Bertram, L, Do, C B, Eriksson, N, Foroud, T, Myers, R H, Benyamin, B, Withfield, J B, Pramstaller, P P, Hicks, A A, Thompson, J R, Minelli, C & Bochdanovits, Z 2013, ' Serum iron levels and the risk of Parkinson disease: a mendelian randomization study ', PLoS Medicine, vol. 10, no. 6, e1001462, pp. 1-13 . https://doi.org/10.1371/journal.pmed.1001462
PLOS Medicine, Vol. 10, No 6 (2013) P. e1001462
PLoS Medicine, 10(6):e1001462, 1-13. Nature Publishing Group
PLoS Medicine, Vol 10, Iss 6, p e1001462 (2013)
PLoS Medicine, 10(6):e1001462, 1-13. Public Library of Science
PLoS medicine, 10(6). Public Library of Science
PLoS Medicine

In this study, Mendelian randomization was used to study genes known to modify iron levels, and the effect of iron on Parkinson's disease (PD) risk was estimated. Based on estimates of the genetic effects on both iron and PD obtained from the largest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1ff83d9ac49e91aea223736fdcdb62
https://hdl.handle.net/11541.2/130162

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Lack of evidence for a role of genetic variation in TMEM230 in the risk for Parkinson's disease in the Caucasian population.

Autor: Giri A; Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany., Mok KY; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Jansen I; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany; Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands., Sharma M; Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany., Tesson C; Institut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS, UMR 7225, Sorbonne Universités, UPMC University Paris 06, UMR S 1127, AP-HP, Pitié-Salpêtrière Hospital, Paris, France., Mangone G; Institut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS, UMR 7225, Sorbonne Universités, UPMC University Paris 06, UMR S 1127, AP-HP, Pitié-Salpêtrière Hospital, Paris, France., Lesage S; Institut du Cerveau et de la Moelle épinière, ICM, Inserm U 1127, CNRS, UMR 7225, Sorbonne Universités, UPMC University Paris 06, UMR S 1127, AP-HP, Pitié-Salpêtrière Hospital, Paris, France., Bras JM; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Shulman JM; Departments of Neurology and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Sheerin UM; Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK., Díez-Fairen M; Movement Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Barcelona, Spain., Pastor P; Movement Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Barcelona, Spain., Martí MJ; Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain., Ezquerra M; Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain., Tolosa E; Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Barcelona, Spain; Institute of Biomedical Research August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain., Correia-Guedes L; Department of Neurosciences, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal., Ferreira J; Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal., Amin N; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., van Duijn CM; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands., van Rooij J; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Ageing (NCHA), Rotterdam, the Netherlands., Uitterlinden AG; Department of Neurosciences, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon, Portugal; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Ageing (NCHA), Rotterdam, the Netherlands., Kraaij R; Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands; Netherlands Consortium for Healthy Ageing (NCHA), Rotterdam, the Netherlands., Nalls M; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Simón-Sánchez J; Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. Electronic address: javier.simon-sanchez@dzne.de.

Publikováno v: Neurobiology of aging [Neurobiol Aging] 2017 Feb; Vol. 50, pp. 167.e11-167.e13. Date of Electronic Publication: 2016 Oct 11.

CHCHD2 and Parkinson's disease.

Autor: Jansen IE; Department of Clinical Genetics, VU University Medical Center, Amsterdam, Netherlands; German Center for Neurodegenerative diseases, Tübingen, Germany., Bras JM; Department of Molecular Neurosciences, Institute of Neurology, University College London, London, UK., Lesage S; Sorbonne Université, Université Pierre et Marie Curie-Paris 06, Inserm, Centre National de la Reserche Scientifique, and Institute du Cerveau et de la Moelle épinière, Paris, France; Assistance Publique Hôpitaux de Paris, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris, France., Schulte C; German Center for Neurodegenerative diseases, Tübingen, Germany; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Gibbs JR; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Brice A; Sorbonne Université, Université Pierre et Marie Curie-Paris 06, Inserm, Centre National de la Reserche Scientifique, and Institute du Cerveau et de la Moelle épinière, Paris, France; Assistance Publique Hôpitaux de Paris, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris, France., Wood NW; Department of Molecular Neurosciences, Institute of Neurology, University College London, London, UK., Morris H; National Hospital for Neurology and Neurosurgery, University College London, London, UK., Hardy JA; Rita Lila Weston Institute, University College London, London, UK., Singleton AB; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA., Gasser T; German Center for Neurodegenerative diseases, Tübingen, Germany; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Heutink P; Department of Clinical Genetics, VU University Medical Center, Amsterdam, Netherlands; German Center for Neurodegenerative diseases, Tübingen, Germany; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany., Sharma M; Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany; Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Silcherstraße 5, 70276, Germany. Electronic address: manu.sharma@uni-tuebingen.de.

Publikováno v: The Lancet. Neurology [Lancet Neurol] 2015 Jul; Vol. 14 (7), pp. 678-9.