Výsledky vyhledávání - "Branwen M. Hall"

Extreme divergence between one-to-one orthologs: the structure of N15 Cro bound to operator DNA and its relationship to the λ Cro complex

Autor: Branwen M. Hall, Matthew H. J. Cordes, Sue A. Roberts

Publikováno v: Nucleic Acids Research

The gene cro promotes lytic growth of phages through binding of Cro protein dimers to regulatory DNA sites. Most Cro proteins are one-to-one orthologs, yet their sequence, structure and binding site sequences are quite divergent across lambdoid phage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c92e6d32e737e8032593111c4c2a47
http://europepmc.org/articles/PMC6649833

Zobrazit plný text záznamu

Multistep mutational transformation of a protein fold through structural intermediates

Autor: Vlad K. Kumirov, Emily M. Dykstra, Taylor N. Szyszka, Matthew H. J. Cordes, Branwen M. Hall, William J. Anderson

Publikováno v: Protein Science. 27:1767-1779

New protein folds may evolve from existing folds through metamorphic evolution involving a dramatic switch in structure. To mimic pathways by which amino acid sequence changes could induce a change in fold, we designed two folded hybrids of Xfaso 1 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd381190d8bfe089e69409c3b143fb2b
https://doi.org/10.1002/pro.3488

Zobrazit plný text záznamu

Two Isoforms of Clp Peptidase in Pseudomonas aeruginosa Control Distinct Aspects of Cellular Physiology

Autor: Gina D. Mawla, Elena B. M. Breidenstein, Cesar de la Fuente-Nunez, Fany Reffuveille, Robert E. W. Hancock, Tania A. Baker, Branwen M. Hall

Publikováno v: Journal of Bacteriology
Journal of Bacteriology, American Society for Microbiology, 2017, 199 (3), ⟨10.1128/JB.00568-16⟩

Caseinolytic peptidases (ClpPs) regulate diverse aspects of cellular physiology in bacteria. Some species have multiple ClpPs, including the opportunistic pathogen Pseudomonas aeruginosa , in which there is an archetypical isoform, ClpP1, and a secon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af4aa9c131f8ab39a2cf8ce9fca2762
https://hal.archives-ouvertes.fr/hal-02528662

Zobrazit plný text záznamu

Reengineering Cro protein functional specificity with an evolutionary code

Autor: Matthew H. J. Cordes, Adrian R. Begaye, Branwen M. Hall, Erin E. Vaughn

Publikováno v: Journal of molecular biology. 413(5)

Cro proteins from different lambdoid bacteriophages are extremely variable in their target consensus DNA sequences and constitute an excellent model for evolution of transcription factor specificity. We experimentally tested a bioinformatically deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407ad9c635f07f6997d374d86c172f20
https://pubmed.ncbi.nlm.nih.gov/21945527

Zobrazit plný text záznamu

Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds

Autor: Matthew H. J. Cordes, Sue A. Roberts, Christian G. Roessler, Wendy Marie Ingram, William R. Montfort, Branwen M. Hall, William J. Anderson

Proteins that share common ancestry may differ in structure and function because of divergent evolution of their amino acid sequences. For a typical diverse protein superfamily, the properties of a few scattered members are known from experiment. A s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de67dc9fe5aac3fff2c2b8319b30680
https://europepmc.org/articles/PMC2268138/

Zobrazit plný text záznamu

Two structures of a lambda Cro variant highlight dimer flexibility but disfavor major dimer distortions upon specific binding of cognate DNA

Autor: Branwen M. Hall, Matthew H. J. Cordes, Sue A. Roberts, Annie Heroux

Publikováno v: Journal of molecular biology. 375(3)

Previously reported crystal structures of free and DNA-bound dimers of lambda Cro differ strongly (about 4 A backbone rmsd), suggesting both flexibility of the dimer interface and induced-fit protein structure changes caused by sequence-specific DNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0320d6ef9120b4a8627e50b3c1ba584
https://pubmed.ncbi.nlm.nih.gov/18054042

Zobrazit plný text záznamu

Sequence correlations between Cro recognition helices and cognate O(R) consensus half-sites suggest conserved rules of protein-DNA recognition

Autor: Matthew H. J. Cordes, Branwen M. Hall, Kelly R. LeFevre

Publikováno v: Journal of molecular biology. 350(4)

The O(R) regions from several lambdoid bacteriophages contain the three regulatory sites O(R)1, O(R)2 and O(R)3, to which the Cro and CI proteins can bind. These sites show imperfect dyad symmetry, have similar sequences, and generally lie on the sam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010b9f66bc67f102950ce6f0a130b3e1
https://pubmed.ncbi.nlm.nih.gov/15967464

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání