Zobrazeno 1 - 10
of 249
pro vyhledávání: '"Brant E Isakson"'
Autor:
Zdravka Daneva, Matteo Ottolini, Yen Lin Chen, Eliska Klimentova, Maniselvan Kuppusamy, Soham A Shah, Richard D Minshall, Cheikh I Seye, Victor E Laubach, Brant E Isakson, Swapnil K Sonkusare
Publikováno v:
eLife, Vol 10 (2021)
Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown. Endothelial transient receptor potential vanilloid
Externí odkaz:
https://doaj.org/article/4e52c48d21c241c0a4496dbc4db01f8d
Autor:
Pratish Thakore, Michael G Alvarado, Sher Ali, Amreen Mughal, Paulo W Pires, Evan Yamasaki, Harry AT Pritchard, Brant E Isakson, Cam Ha T Tran, Scott Earley
Publikováno v:
eLife, Vol 10 (2021)
Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary endothelial cells are stimulated by neuronal activity and instigate a propagat
Externí odkaz:
https://doaj.org/article/7b23c918a6444d5fb49cd757a865a485
Autor:
Brant E Isakson
Publikováno v:
Journal of Medical Sciences, Vol 37, Iss 5, Pp 179-185 (2017)
Pannexin proteins comprise a family of channels whose sole function, to date, is the release of nucleotides (e.g., adenosine 5'-triphosphate [ATP] and uridine 5′-triphosphate [UTP]). With purinergic signaling being such a prevalent form of cellular
Externí odkaz:
https://doaj.org/article/4dc596653ab14578be823e6b420806cd
Autor:
Claire A. Ruddiman, Richard Peckham, Melissa A. Luse, Yen-Lin Chen, Maniselvan Kuppusamy, Bruce A. Corliss, P. Jordan Hall, Chien-Jung Lin, Shayn M. Peirce, Swapnil K. Sonkusare, Robert P. Mecham, Jessica E. Wagenseil, Brant E. Isakson
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular environments remain el
Externí odkaz:
https://doaj.org/article/7e3053ea3fba4f4ebcd0e85d89274a84
Autor:
Tristan J. Ragland, Emily M. Heiston, Anna Ballantyne, Nathan R. Stewart, Sabrina La Salvia, Luca Musante, Melissa A. Luse, Brant E. Isakson, Uta Erdbrügger, Steven K. Malin
Publikováno v:
Physiological Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract Metabolic Syndrome (MetS) raises cardiovascular disease risk. Extracellular vesicles (EVs) have emerged as important mediators of insulin sensitivity, although few studies on vascular function exist in humans. We determined the effect of ins
Externí odkaz:
https://doaj.org/article/09efe118087d451c8c600c93d7f901af
Autor:
Soham A. Shah, Claire E. Reagan, Julia E. Bresticker, Abigail G. Wolpe, Miranda E. Good, Edgar H. Macal, Helen O. Billcheck, Leigh A. Bradley, Brent A. French, Brant E. Isakson, Matthew J. Wolf, Frederick H. Epstein
Publikováno v:
JACC: Basic to Translational Science. 8:501-514
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a388786b22f91065b5a3284451adc9b6
https://doi.org/10.1016/j.jacbts.2022.11.005
https://doi.org/10.1016/j.jacbts.2022.11.005
Autor:
Pei-Lun Chu, Joseph C. Gigliotti, Sylvia Cechova, Gabor Bodonyi-Kovacs, Yves T. Wang, Luojing Chen, Sylvia Wassertheil-Smoller, Jianwen Cai, Brant E. Isakson, Nora Franceschini, Thu H. Le
Publikováno v:
American Journal of Physiology-Renal Physiology. 324:F30-F42
The findings of our study are significant in several ways: 1) loss of an amino acid chaperone in the proximal tubule is sufficient to cause hypertension, 2) the results in global and proximal tubule-specific collectrin knockout mice support the notio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8916a7e38d01f9f03b405373b05af6d2
https://doi.org/10.1152/ajprenal.00176.2022
https://doi.org/10.1152/ajprenal.00176.2022
Autor:
D. Ryan King, Meghan W. Sedovy, Xinyan Leng, Jianxiang Xue, Samy Lamouille, Michael Koval, Brant E. Isakson, Scott R. Johnstone
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10186 (2021)
Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been found to be involved in multiple pathophysiological states from cancer to cardiovascular disease. Studies over the last 60 years have demonstrated the utility o
Externí odkaz:
https://doaj.org/article/9ab401de873e408cbf54567e7eac8c4b
Autor:
D. Ryan King, Meghan W. Sedovy, Xinyan Eaton, Luke S. Dunaway, Miranda E. Good, Brant E. Isakson, Scott R. Johnstone
Publikováno v:
Comprehensive Physiology. :3833-3867
The arterial vasculature can be divided into large conduit arteries, intermediate contractile arteries, resistance arteries, arterioles, and capillaries. Resistance arteries and arterioles primarily function to control systemic blood pressure. The re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614cb2100ed1dbfa85c1fc3d6e355cc4
https://doi.org/10.1002/cphy.c210040
https://doi.org/10.1002/cphy.c210040
Autor:
Junyoung Hong, Miguel Martin-Aragon Baudel, Gopyreddy R Reddy, Yumna A Moustafa, Jose W Ayende, Yaseen Mohabbat, Brant E Isakson, Madeline Nieves-Cintron, Manuel F Navedo
Publikováno v:
Physiology. 38
Vascular complications are major causes of morbidity and mortality in diabetic patients. Recently, our group identified a novel purinergic signaling pathway involving the AKAP5/P2Y11/AC5/PKA/CaV1.2 protein network in arterial myocytes that is activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5346c9c048c352604d9808f73aa12abf
https://doi.org/10.1152/physiol.2023.38.s1.5731650
https://doi.org/10.1152/physiol.2023.38.s1.5731650