Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Brant E, Isakson"'
Autor:
T. C. Stevenson Keller, Christophe Lechauve, Alexander S. Keller, Gilson Brás Broseghini-Filho, Joshua T. Butcher, Henry R. Askew Page, Aditi Islam, Zhe Yin Tan, Leon J. DeLalio, Steven Brooks, Poonam Sharma, Kwangseok Hong, Wenhao Xu, Alessandra Simão Padilha, Claire A. Ruddiman, Angela K. Best, Edgar Macal, Daniel B. Kim-Shapiro, George Christ, Zhen Yan, Miriam M. Cortese-Krott, Karina Ricart, Rakesh Patel, Timothy P. Bender, Swapnil K. Sonkusare, Mitchell J. Weiss, Hans Ackerman, Linda Columbus, Brant E. Isakson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
In mammals, hypoxia causes dilation of small arteries for increased metabolic demand. Keller et al used novel transgenic mice to show alpha hemoglobin in endothelium, once thought only in red blood cells, can regulate hypoxic-mediated dilation.
Externí odkaz:
https://doaj.org/article/b9f465340f0741ff838bff1e07d81c95
Autor:
Claire A. Ruddiman, Richard Peckham, Melissa A. Luse, Yen-Lin Chen, Maniselvan Kuppusamy, Bruce A. Corliss, P. Jordan Hall, Chien-Jung Lin, Shayn M. Peirce, Swapnil K. Sonkusare, Robert P. Mecham, Jessica E. Wagenseil, Brant E. Isakson
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular environments remain el
Externí odkaz:
https://doaj.org/article/7e3053ea3fba4f4ebcd0e85d89274a84
Autor:
Amanda C. Filiberto, Michael D. Spinosa, Craig T. Elder, Gang Su, Victoria Leroy, Zachary Ladd, Guanyi Lu, J. Hunter Mehaffey, Morgan D. Salmon, Robert B. Hawkins, Kodi S. Ravichandran, Brant E. Isakson, Gilbert R. Upchurch, Ashish K. Sharma
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Pannexin-1 ion channels on endothelial cells regulate vascular inflammation and remodeling to mediate aortic aneurysm formation. Pharmacological blockade of Pannexin-1 channels may offer translational therapeutic mitigation of aneurysmal pathology.
Externí odkaz:
https://doaj.org/article/5d2bdb9d8cc044ab83c636b0eec19b6c
Autor:
Tristan J. Ragland, Emily M. Heiston, Anna Ballantyne, Nathan R. Stewart, Sabrina La Salvia, Luca Musante, Melissa A. Luse, Brant E. Isakson, Uta Erdbrügger, Steven K. Malin
Publikováno v:
Physiological Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract Metabolic Syndrome (MetS) raises cardiovascular disease risk. Extracellular vesicles (EVs) have emerged as important mediators of insulin sensitivity, although few studies on vascular function exist in humans. We determined the effect of ins
Externí odkaz:
https://doaj.org/article/09efe118087d451c8c600c93d7f901af
Autor:
Kanchan Bisht, Kenneth A. Okojie, Kaushik Sharma, Dennis H. Lentferink, Yu-Yo Sun, Hong-Ru Chen, Joseph O. Uweru, Saipranusha Amancherla, Zainab Calcuttawala, Antony Brayan Campos-Salazar, Bruce Corliss, Lara Jabbour, Jordan Benderoth, Bria Friestad, William A. Mills, Brant E. Isakson, Marie-Ève Tremblay, Chia-Yi Kuan, Ukpong B. Eyo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Microglia are involved in debris clearance and synaptic pruning, among other processes. However, their direct interaction with the brain vasculature is less clear. Here, the authors show that capillary-associated microglia (CAMs) regulate vascular to
Externí odkaz:
https://doaj.org/article/8c3b78ae6a934bf382bdde9f4a4a758d
Autor:
Mitchell E. Granade, Stefan R. Hargett, Daniel S. Lank, Michael C. Lemke, Melissa A. Luse, Brant E. Isakson, Irina M. Bochkis, Joel Linden, Thurl E. Harris
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101543- (2022)
Objective: Adipose tissue is a critical regulator of energy balance that must rapidly shift its metabolism between fasting and feeding to maintain homeostasis. Adenosine has been characterized as an important regulator of adipocyte metabolism primari
Externí odkaz:
https://doaj.org/article/4d0f181c11f14a62817560bbc6f02485
Autor:
Miriam M. Cortese-Krott, Tatsiana Suvorava, Francesca Leo, Sophia K. Heuser, Anthea LoBue, Junjie Li, Stefanie Becher, Rebekka Schneckmann, Tanu Srivrastava, Ralf Erkens, Georg Wolff, Joachim P. Schmitt, Maria Grandoch, Jon O. Lundberg, John Pernow, Brant E. Isakson, Eddie Weitzberg, Malte Kelm
Publikováno v:
Redox Biology, Vol 54, Iss , Pp 102370- (2022)
Red blood cells (RBCs) were shown to transport and release nitric oxide (NO) bioactivity and carry an endothelial NO synthase (eNOS). However, the pathophysiological significance of RBC eNOS for cardioprotection in vivo is unknown. Here we aimed to a
Externí odkaz:
https://doaj.org/article/b3929b71cddb4e96b40d04fba5670f37
Autor:
Zdravka Daneva, Matteo Ottolini, Yen Lin Chen, Eliska Klimentova, Maniselvan Kuppusamy, Soham A Shah, Richard D Minshall, Cheikh I Seye, Victor E Laubach, Brant E Isakson, Swapnil K Sonkusare
Publikováno v:
eLife, Vol 10 (2021)
Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown. Endothelial transient receptor potential vanilloid
Externí odkaz:
https://doaj.org/article/4e52c48d21c241c0a4496dbc4db01f8d
Autor:
Claudia M. Rival, Wenhao Xu, Laura S. Shankman, Sho Morioka, Sanja Arandjelovic, Chang Sup Lee, Karen M. Wheeler, Ryan P. Smith, Lisa B. Haney, Brant E. Isakson, Scott Purcell, Jeffrey J. Lysiak, Kodi S. Ravichandran
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Izumo and Juno are receptors on sperm and eggs respectively required for fusion, but other factors for sperm-egg fusion are poorly studied. Here, the authors report that phosphatidylserine, found mainly on cells marked for death, is also present on m
Externí odkaz:
https://doaj.org/article/89356b6243dc4c859d4c2eaf9ae0cf51
Autor:
Soham A. Shah, Claire E. Reagan, Julia E. Bresticker, Abigail G. Wolpe, Miranda E. Good, Edgar H. Macal, Helen O. Billcheck, Leigh A. Bradley, Brent A. French, Brant E. Isakson, Matthew J. Wolf, Frederick H. Epstein
Publikováno v:
JACC: Basic to Translational Science. 8:501-514
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a388786b22f91065b5a3284451adc9b6
https://doi.org/10.1016/j.jacbts.2022.11.005
https://doi.org/10.1016/j.jacbts.2022.11.005