A Protein‐Based Pentavalent Inhibitor of the Cholera Toxin B‐Subunit

Autor: Branson, TR, McAllister, TE, Garcia-Hartjes, J, Fascione, MA, Ross, JF, Warriner, SL, Wennekes, T, Zuilhof, H, Turnbull, WB

Protein toxins produced by bacteria are the cause of many life-threatening diarrheal diseases. Many of these toxins, including cholera toxin (CT), enter the cell by first binding to glycolipids in the cell membrane. Inhibiting these multivalent prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::87b761773297fb97e3ccd0a76cafe6cf

Membrane Fusion Mediated by Non-covalent Binding of Re-engineered Cholera Toxin Assemblies to Glycolipids.

Autor: Wehrum S; Faculty of Biology, Albert-Ludwigs-University Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany.; Bioss-Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany., Siukstaite L; Faculty of Biology, Albert-Ludwigs-University Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany.; Bioss-Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany., Williamson DJ; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, LS2 9JT Leeds, U.K.., Branson TR; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, LS2 9JT Leeds, U.K.., Sych T; Faculty of Biology, Albert-Ludwigs-University Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany.; Bioss-Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany.; Freiburg Center for Interactive Materials and Bioinspired Technology (FIT), Albert-Ludwigs-University Freiburg, Georges-Köhler-Allee 105, 79110 Freiburg, Germany.; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, 17165 Solna, Sweden., Madl J; Faculty of Biology, Albert-Ludwigs-University Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany.; Bioss-Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany.; Freiburg Center for Interactive Materials and Bioinspired Technology (FIT), Albert-Ludwigs-University Freiburg, Georges-Köhler-Allee 105, 79110 Freiburg, Germany., Wildsmith GC; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, LS2 9JT Leeds, U.K.., Dai W; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, LS2 9JT Leeds, U.K.., Kempmann E; Faculty of Biology, Albert-Ludwigs-University Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany.; Bioss-Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany., Ross JF; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, LS2 9JT Leeds, U.K.., Thomsen M; School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds, LS2 9JT Leeds, U.K.., Webb ME; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, LS2 9JT Leeds, U.K.., Römer W; Faculty of Biology, Albert-Ludwigs-University Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany.; Bioss-Centre for Biological Signalling Studies, Albert-Ludwigs-University Freiburg, Schänzlestraße 18, 79104 Freiburg, Germany.; Freiburg Center for Interactive Materials and Bioinspired Technology (FIT), Albert-Ludwigs-University Freiburg, Georges-Köhler-Allee 105, 79110 Freiburg, Germany., Turnbull WB; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, LS2 9JT Leeds, U.K..

Publikováno v: ACS synthetic biology [ACS Synth Biol] 2022 Dec 16; Vol. 11 (12), pp. 3929-3938. Date of Electronic Publication: 2022 Nov 11.

Tetra- versus Pentavalent Inhibitors of Cholera Toxin.

Autor: Fu O; Department of Medicinal Chemistry and Chemical Biology, Utrecht University P.O. Box 80082, 3508 TB, Utrecht, The Netherlands., Pukin AV; Department of Medicinal Chemistry and Chemical Biology, Utrecht University P.O. Box 80082, 3508 TB, Utrecht, The Netherlands., van Ufford HC; Department of Medicinal Chemistry and Chemical Biology, Utrecht University P.O. Box 80082, 3508 TB, Utrecht, The Netherlands., Branson TR; Department of Medicinal Chemistry and Chemical Biology, Utrecht University P.O. Box 80082, 3508 TB, Utrecht, The Netherlands ; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds Leeds, LS2 9JT, United Kingdom., Thies-Weesie DM; Van 't Hoff Laboratory for Physical and Colloid Chemistry, Debye Institute for Nanomaterials Science, Utrecht University Padualaan 8, 3584 CH, Utrecht, The Netherlands., Turnbull WB; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds Leeds, LS2 9JT, United Kingdom., Visser GM; Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University PO Box 80.165, 3508 TD, Utrecht, The Netherlands., Pieters RJ; Department of Medicinal Chemistry and Chemical Biology, Utrecht University P.O. Box 80082, 3508 TB, Utrecht, The Netherlands.

Publikováno v: ChemistryOpen [ChemistryOpen] 2015 Aug; Vol. 4 (4), pp. 471-7. Date of Electronic Publication: 2015 Mar 21.

Bacterial toxin inhibitors based on multivalent scaffolds.

Autor: Branson TR; School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK., Turnbull WB

Publikováno v: Chemical Society reviews [Chem Soc Rev] 2013 Jun 07; Vol. 42 (11), pp. 4613-22. Date of Electronic Publication: 2012 Dec 21.