Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Branko V. Latinkić"'
Autor:
Lee J Samuel, Branko V Latinkić
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7650 (2009)
BACKGROUND:Cardiac induction, the first step in heart development in vertebrate embryos, is thought to be initiated by anterior endoderm during gastrulation, but what the signals are and how they act is unknown. Several signaling pathways, including
Externí odkaz:
https://doaj.org/article/105b0832daa94c509044cb75f6424163
Autor:
Pavel Kirilenko, Abir Yamak, Chantal Lefebvre, Branko V. Latinkić, Matthias Bochtler, Joseph M. Gallagher, Sarah Black, Mona Nemer
Publikováno v:
Mechanisms of Development
Highlights • Carboxy terminal region of GATA4 is required for cardiogenesis in Xenopus pluripotent explants and in embryos. • Carboxy terminus of GATA4 interacts with CDK4. • CDK4 enhances transcriptional and cardiogenic activity of GATA4. •
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a31456db42119dae242783e4e1c75b9
http://europepmc.org/articles/PMC4259525
http://europepmc.org/articles/PMC4259525
Publikováno v:
Molecular and Cellular Biology. 32:2214-2223
Transcription factor GATA4 is a critical regulator of the embryonic and postnatal heart, but the mechanisms and cofactors required for its diverse functions are not fully understood. Here, we show that whereas the N-terminal domain of GATA4 is requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60849943e8c43386ae5504c9b93a60c4
https://doi.org/10.1128/mcb.00218-12
https://doi.org/10.1128/mcb.00218-12
Publikováno v:
The Journal of Physiology. 587:521-529
NKCC1 is a broadly expressed Na+–K+–Cl− co-transporter involved in regulation of ion flux across the cell membrane and in regulating cell volume. Whilst much is known about the co-transporter activity of NKCC1 and its regulation by protein kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac86cd78bcf5a31853092767b25316c
https://doi.org/10.1113/jphysiol.2008.161562
https://doi.org/10.1113/jphysiol.2008.161562
Autor:
Stuart J. Smith, Surendra Kotecha, Norma Towers, Timothy J. Mohun, Brian Cooper, Branko V. Latinkić, Duncan B. Sparrow
Publikováno v:
Development. 131:669-679
The mechanisms by which transcription factors, which are not themselves tissue restricted, establish cardiomyocyte-specific patterns of transcription in vivo are unknown. Nor do we understand how positional cues are integrated to provide regionally d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290797c14fe38f93afc4e7daf0c074e2
https://doi.org/10.1242/dev.00953
https://doi.org/10.1242/dev.00953
Publikováno v:
Development. 130:3865-3876
The earliest step in heart formation in vertebrates occurs during gastrulation, when cardiac tissue is specified. Dorsoanterior endoderm is thought to provide a signal that induces adjacent mesodermal cells to adopt a cardiac fate. However, the natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b49089fe753b4386bd15338ab23a3fd
https://doi.org/10.1242/dev.00599
https://doi.org/10.1242/dev.00599
The G1 cyclins play a pivotal role in regulation of cell differentiation and proliferation. The mechanisms underlying their cell-specific roles are incompletely understood. Here, we show that a G1 cyclin, cyclin D2 (CycD2), enhances the activity of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e043863fb23c08670c5e0b5f291b085
Autor:
Branko V. Latinkić, Duncan B. Sparrow, Timothy J. Mohun, Sylvia M. Evans, Brian Cooper, Chen-Leng Cai, Surendra Kotecha, Norma Towers
Publikováno v:
Developmental Biology. 227:65-79
Vertebrate homologues of the Drosophila tinman transcription factor have been implicated in the processes of specification and differentiation of cardiac mesoderm. In Xenopus three members of this family have been isolated to date. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30f6ec94f0a6e0510b3675151976688
https://doi.org/10.1006/dbio.2000.9891
https://doi.org/10.1006/dbio.2000.9891
Publikováno v:
Europe PubMed Central
Tissue specification in the early embryo requires the integration of spatial information at the promoters of developmentally important genes. Although several response elements for signalling pathways have been identified in Xenopus promoters, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e05c6197971d7928422308ce05cf91
https://doi.org/10.1242/dev.127.12.2729
https://doi.org/10.1242/dev.127.12.2729
Autor:
Branko V. Latinkić, James C. Smith
Publikováno v:
Development. 126:1769-1779
The Xenopus homologue of Brachyury, Xbra, is expressed in the presumptive mesoderm of the early gastrula. Induction of Xbra in animal pole tissue by activin occurs only in a narrow window of activin concentrations; if the level of inducer is too high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108ffc52f0e9aaa8e6e80a1e6a61f568
https://doi.org/10.1242/dev.126.8.1769
https://doi.org/10.1242/dev.126.8.1769