Výsledky vyhledávání - "Brandy M. Heckman-Stoddard"

Akademický článek

Alternative dosing regimen of exemestane in a randomized presurgical trial: the role of obesity in biomarker modulation

Publikováno v: npj Breast Cancer, Vol 10, Iss 1, Pp 1-8 (2024)

Abstract In a 3-arm presurgical trial, four-six weeks exemestane 25 mg three times/week (TIW) was non-inferior to 25 mg/day (QD) in suppressing circulating estradiol in postmenopausal women with ER-positive breast cancer. Since obesity may decrease e

Externí odkaz: https://doaj.org/article/d80f769e4684451285f4994baf3c0f8c

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Akademický článek

A randomized Phase I pre-operative window trial of transdermal endoxifen in women planning mastectomy: Evaluation of dermal safety, intra-mammary drug distribution, and biologic effects

Autor: Oukseub Lee, Latifa A. Bazzi, Yanfei Xu, Erik Pearson, Minhua Wang, Omid Hosseini, Azza M. Akasha, Jennifer Nam Choi, Scott Karlan, Melissa Pilewskie, Masha Kocherginsky, Kelly Benante, Thomas Helland, Gunnar Mellgren, Eileen Dimond, Marjorie Perloff, Brandy M. Heckman-Stoddard, Seema A. Khan

Publikováno v: Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116105- (2024)

Breast cancer prevention only requires local exposure of the breast to active drug. However, oral preventive agents entail systemic exposure, causing adverse effects that limit acceptance by high-risk women. Drug-delivery through the breast skin is a

Externí odkaz: https://doaj.org/article/866b000bd0524b18baec1ef3a47518c6

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Akademický článek

Breast cancer risk for women with diabetes and the impact of metformin: A meta‐analysis

Autor: Yifan Lu, Ali Hajjar, Vincent L. Cryns, Amy Trentham‐Dietz, Ronald E. Gangnon, Brandy M. Heckman‐Stoddard, Oguzhan Alagoz

Publikováno v: Cancer Medicine, Vol 12, Iss 10, Pp 11703-11718 (2023)

Abstract Background Diabetes mellitus has been associated with increased breast cancer (BC) risk; however, the magnitude of this effect is uncertain. This study focused on BC risk for women with type 2 diabetes mellitus (T2DM). Methods Two separate m

Externí odkaz: https://doaj.org/article/05ec6330400c4aa4ae9fb75302950c00

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Akademický článek

The 2018 World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) score and diabetes risk in the Diabetes Prevention Program Outcomes Study (DPPOS)

Autor: Marissa M. Shams-White, Ashley H. Tjaden, Sharon L. Edelstein, Sarah Bassiouni, Lisa L. Kahle, Catherine Kim, Xavier Pi-Sunyer, Karla A. Temple, Elizabeth M. Venditti, Jill Reedy, Brandy M. Heckman-Stoddard, DPP Research Group

Publikováno v: BMC Nutrition, Vol 8, Iss 1, Pp 1-11 (2022)

Abstract Background The 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) 3rd expert report highlights up-to-date Cancer Prevention Recommendations that may reduce burdens of many chronic diseases, including diabetes.

Externí odkaz: https://doaj.org/article/2e8dd33e3eca4f20abae3186399c07f8

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Akademický článek

Modeling the natural history of ductal carcinoma in situ based on population data

Autor: Sarocha Chootipongchaivat, Nicolien T. van Ravesteyn, Xiaoxue Li, Hui Huang, Harald Weedon-Fekjær, Marc D. Ryser, Donald L. Weaver, Elizabeth S. Burnside, Brandy M. Heckman-Stoddard, Harry J. de Koning, Sandra J. Lee

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-12 (2020)

Abstract Background The incidence of ductal carcinoma in situ (DCIS) has increased substantially since the introduction of mammography screening. Nevertheless, little is known about the natural history of preclinical DCIS in the absence of biopsy or

Externí odkaz: https://doaj.org/article/f2f4c55d91484272af8efb3a036fe004

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Phase II Trial of Nelipepimut-S Peptide Vaccine in Women with Ductal Carcinoma In Situ

Autor: Anne E. O'Shea, Guy T. Clifton, Na Qiao, Brandy M. Heckman-Stoddard, Malgorzata Wojtowicz, Eileen Dimond, Isabelle Bedrosian, Diane Weber, Judy E. Garber, Alexander Husband, Ricardo Pastorello, J. Jack Lee, Mike Hernandez, Diane D. Liu, Lana A. Vornik, Powel H. Brown, Gheath Alatrash, George E. Peoples, Elizabeth A. Mittendorf

Publikováno v: Cancer Prevention Research. :OF1-OF9

NeuVax is a vaccine comprised of the HER2-derived MHC class I peptide E75 (nelipepimut-S, NPS) combined with GM-CSF. We completed a randomized trial of preoperative vaccination with NeuVax versus GM-CSF alone in patients with ductal carcinoma in situ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d154d04691dbeb3114f4e7e4d82dea9
https://doi.org/10.1158/1940-6207.capr-22-0388

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Lessons from the Failure to Complete a Trial of Denosumab in Women With a Pathogenic BRCA1/2 Variant Scheduling Risk-Reducing Salpingo-Oophorectomy

Autor: Meghna S. Trivedi, Nadir Arber, Eitan Friedman, Judy E. Garber, Kevin Holcomb, Neil S. Horowitz, Jason D. Wright, J. Jack Lee, Lana A. Vornik, Saba Abutaseh, Tawana Castile, Edward R. Sauter, Eileen Dimond, Brandy M. Heckman-Stoddard, Margaret House, Goli Samimi, Powel H. Brown, Katherine D. Crew

Publikováno v: Cancer Prevention Research. 15:721-726

Female carriers of pathogenic/likely pathogenic (P/LP) BRCA1/2 variants are at increased risk of developing breast and ovarian cancer. Currently, the only effective strategy for ovarian cancer risk reduction is risk-reducing bilateral salpingo-oophor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08dc6bab8ca152e7fe9d640fd7c9ca7
https://doi.org/10.1158/1940-6207.capr-22-0051

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