Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Brandon Leonard"'
Autor:
Matthew G. Romei, Brandon Leonard, Zachary B. Katz, Daniel Le, Yanli Yang, Eric S. Day, Christopher W. Koo, Preeti Sharma, Jack Bevers III, Ingrid Kim, Huiguang Dai, Farzam Farahi, May Lin, Andrey S. Shaw, Gerald Nakamura, Jonathan T. Sockolosky, Greg A. Lazar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The ability to leverage antibodies to agonize disease relevant biological pathways has tremendous potential for clinical investigation. Yet while antibodies have been successful as antagonists, immune mediators, and targeting agents, they ar
Externí odkaz:
https://doaj.org/article/17d263c9cfc746cea0b227c5efde646d
Autor:
Yizhou Yin, Matthew G. Romei, Kannan Sankar, Lipika R. Pal, Kam Hon Hoi, Yanli Yang, Brandon Leonard, Gladys De Leon Boenig, Nikit Kumar, Marissa Matsumoto, Jian Payandeh, Seth F. Harris, John Moult, Greg A. Lazar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4952-4968 (2022)
Antibodies are fundamental effectors of humoral immunity, and have become a highly successful class of therapeutics. There is increasing evidence that antibodies utilize transient homotypic interactions to enhance function, and elucidation of such in
Externí odkaz:
https://doaj.org/article/60f793838e994b85be80002d6d453dc0
Autor:
Yvonne Chen, Maciej Paluch, Julie A. Zorn, Sharmila Rajan, Brandon Leonard, Alberto Estevez, John Brady, Henry Chiu, Wilson Phung, Amin Famili, Minhong Yan, Claudio Ciferri, Marissa L. Matsumoto, Greg A. Lazar, Susan Crowell, Phil Hass, Nicholas J. Agard
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Treatment of ocular disease is hindered by the presence of the blood-retinal barrier, which restricts access of systemic drugs to the eye. Intravitreal injections bypass this barrier, delivering high concentrations of drug to the targeted tissue. How
Externí odkaz:
https://doaj.org/article/28ad3cfcdaf4459abab263005b66f32a
Autor:
Michael J. Rovito, Brandon Leonard, Ramon Llamas, James E. Leone, Walker Talton, Ana Fadich, Peter Baker
Publikováno v:
American Journal of Men's Health, Vol 11 (2017)
The WHO’s “Global Strategy for Women’s, Children’s, and Adolescents’ Health 2016-2030” (GS-WCAH 2016-2030) is a comprehensive plan developed to improve the lives of women, children, and adolescents. Due to the success in the creation, rat
Externí odkaz:
https://doaj.org/article/97197afbc7224a38a12738c8e8c7515c
Publikováno v:
Biomedical Journal, Vol 38, Iss 2, Pp 102-110 (2015)
Cancer is a disease that results from alterations in the cellular genome. Several recent studies have identified mutational signatures that implicate a variety of mutagenic processes in cancer, a major one of which is explained by the enzymatic activ
Externí odkaz:
https://doaj.org/article/d5c44052466e433e9e773a90299a0a64
Autor:
Valdimara C. Vieira, Brandon Leonard, Elizabeth A. White, Gabriel J. Starrett, Nuri A. Temiz, Laurel D. Lorenz, Denis Lee, Marcelo A. Soares, Paul F. Lambert, Peter M. Howley, Reuben S. Harris
Publikováno v:
mBio, Vol 5, Iss 6 (2014)
ABSTRACT Several recent studies have converged upon the innate immune DNA cytosine deaminase APOBEC3B (A3B) as a significant source of genomic uracil lesions and mutagenesis in multiple human cancers, including those of the breast, head/neck, cervix,
Externí odkaz:
https://doaj.org/article/78b02926d2814d79a2e5419970d5363e
Autor:
Neil E. Bhola, Jennifer R. Grandis, Hua Li, Jacquelyn D. Kemmer, Yan Zeng, Eliot D. Lee, Rachel A. O'Keefe, Toni M. Brand, Brandon Leonard
Assessment of membranous EGFR expression in PECAPJ49 parental and CTXR#4 treated with and without cetuximab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cac08369cac384dde9f9d70b4e65bee
https://doi.org/10.1158/0008-5472.22418337
https://doi.org/10.1158/0008-5472.22418337
Autor:
Neil E. Bhola, Jennifer R. Grandis, Hua Li, Jacquelyn D. Kemmer, Yan Zeng, Eliot D. Lee, Rachel A. O'Keefe, Toni M. Brand, Brandon Leonard
Schematic representing the generation of acquired cetuximab resistant HNSCC models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059ec55501f181d5ae6f2fca7340e7b2
https://doi.org/10.1158/0008-5472.22418346
https://doi.org/10.1158/0008-5472.22418346
Autor:
Reuben S. Harris, Scott H. Kaufmann, Kimberly R. Kalli, William L. Brown, Brett D. Anderson, John W.M. Martens, Els M.J.J. Berns, Anieta M. Sieuwerts, Jozien Helleman, Olivier De Wever, Jo Van Dorpe, Mieke Van Bockstal, Ann L. Oberg, Matthew J. Maurer, Gabriel J. Starrett, Brandon Leonard
Purpose: APOBEC3 DNA cytosine deaminase family members normally defend against viruses and transposons. However, deregulated APOBEC3 activity causes mutations in cancer. Because of broad expression profiles and varying mixtures of normal and cancer c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8362452eadd51419a694087c9ef3e0e8
https://doi.org/10.1158/1078-0432.c.6525488.v1
https://doi.org/10.1158/1078-0432.c.6525488.v1
Autor:
Neil E. Bhola, Jennifer R. Grandis, Hua Li, Jacquelyn D. Kemmer, Yan Zeng, Eliot D. Lee, Rachel A. O'Keefe, Toni M. Brand, Brandon Leonard
Evaluation of RTK and BRD4 expression from clinical HNSCC datasets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a546027ce1968262c016b5a9025d6537
https://doi.org/10.1158/0008-5472.22418325.v1
https://doi.org/10.1158/0008-5472.22418325.v1