Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Brandon J. DeKosky"'
Autor:
Bailey B. Banach, Sergei Pletnev, Adam S. Olia, Kai Xu, Baoshan Zhang, Reda Rawi, Tatsiana Bylund, Nicole A. Doria-Rose, Thuy Duong Nguyen, Ahmed S. Fahad, Myungjin Lee, Bob C. Lin, Tracy Liu, Mark K. Louder, Bharat Madan, Krisha McKee, Sijy O’Dell, Mallika Sastry, Arne Schön, Natalie Bui, Chen-Hsiang Shen, Jacy R. Wolfe, Gwo-Yu Chuang, John R. Mascola, Peter D. Kwong, Brandon J. DeKosky
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The HIV-1 fusion peptide (FP) represents a promising vaccine target, but global FP sequence diversity among circulating strains has limited anti-FP antibodies to ~60% neutralization breadth. Here we evolve the FP-targeting antibody VRC34.01
Externí odkaz:
https://doaj.org/article/e636e8ff307e4e158f7f9667c39522e1
Autor:
Ahmed S. Fahad, Cheng Yu Chung, Sheila N. López Acevedo, Nicoleen Boyle, Bharat Madan, Matías F. Gutiérrez-González, Rodrigo Matus-Nicodemos, Amy D. Laflin, Rukmini R. Ladi, John Zhou, Jacy Wolfe, Sian Llewellyn-Lacey, Richard A. Koup, Daniel C. Douek, Henry H. Balfour, David A. Price, Brandon J. DeKosky
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Adoptive immune therapies based on the transfer of antigen-specific T cells have been used successfully to treat various cancers and viral infections, but improved techniques are needed to identify optimally protective human T cell receptors
Externí odkaz:
https://doaj.org/article/eeee0fb53a204636b7baa68d6140de84
Autor:
Xiaoli Pan, Sheila N. López Acevedo, Camille Cuziol, Evelyn De Tavernier, Ahmed S. Fahad, Priyobarta S. Longjam, Sambasiva P. Rao, David Aguilera-Rodríguez, Mathilde Rezé, Christine A. Bricault, Matías F. Gutiérrez-González, Matheus Oliveira de Souza, Joshua M. DiNapoli, Emmanuelle Vigne, Melody A. Shahsavarian, Brandon J. DeKosky
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Molecular characterization of antibody immunity and human antibody discovery is mainly carried out using peripheral memory B cells, and occasionally plasmablasts, that express B cell receptors (BCRs) on their cell surface. Despite the importance of p
Externí odkaz:
https://doaj.org/article/49fb3a23f5d142acb94df6b620d91928
Autor:
Matheus Oliveira de Souza, Bharat Madan, I-Ting Teng, Aric Huang, Lihong Liu, Ahmed S. Fahad, Sheila N. Lopez Acevedo, Xiaoli Pan, Mallika Sastry, Matias Gutierrez-Gonzalez, Michael T. Yin, Tongqing Zhou, David D. Ho, Peter D. Kwong, Brandon J. DeKosky
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged continuously, challenging the effectiveness of vaccines, diagnostics, and treatments. Moreover, the possibility of the appearance of a new betacoronavirus with high
Externí odkaz:
https://doaj.org/article/51ec406235d64c07aad5189938a500fb
Autor:
I-Ting Teng, Alexandra F. Nazzari, Misook Choe, Tracy Liu, Matheus Oliveira de Souza, Yuliya Petrova, Yaroslav Tsybovsky, Shuishu Wang, Baoshan Zhang, Mykhaylo Artamonov, Bharat Madan, Aric Huang, Sheila N. Lopez Acevedo, Xiaoli Pan, Tracy J. Ruckwardt, Brandon J. DeKosky, John R. Mascola, John Misasi, Nancy J. Sullivan, Tongqing Zhou, Peter D. Kwong
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Since the outbreak of the COVID-19 pandemic, widespread infections have allowed SARS-CoV-2 to evolve in human, leading to the emergence of multiple circulating variants. Some of these variants show increased resistance to vaccine-elicited immunity, c
Externí odkaz:
https://doaj.org/article/e5a8c92f945a4ab6888b6ebc59258593
Autor:
Bailey B. Banach, Gabriele Cerutti, Ahmed S. Fahad, Chen-Hsiang Shen, Matheus Oliveira De Souza, Phinikoula S. Katsamba, Yaroslav Tsybovsky, Pengfei Wang, Manoj S. Nair, Yaoxing Huang, Irene M. Francino-Urdániz, Paul J. Steiner, Matías Gutiérrez-González, Lihong Liu, Sheila N. López Acevedo, Alexandra F. Nazzari, Jacy R. Wolfe, Yang Luo, Adam S. Olia, I-Ting Teng, Jian Yu, Tongqing Zhou, Eswar R. Reddem, Jude Bimela, Xiaoli Pan, Bharat Madan, Amy D. Laflin, Rajani Nimrania, Kwok-Yung Yuen, Timothy A. Whitehead, David D. Ho, Peter D. Kwong, Lawrence Shapiro, Brandon J. DeKosky
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109771- (2021)
Summary: Understanding mechanisms of protective antibody recognition can inform vaccine and therapeutic strategies against SARS-CoV-2. We report a monoclonal antibody, 910-30, targeting the SARS-CoV-2 receptor-binding site for ACE2 as a member of a p
Externí odkaz:
https://doaj.org/article/eeb91ec1080042a7abf186e7a830013e
Autor:
Brian M. Petersen, Sophia A. Ulmer, Emily R. Rhodes, Matias F. Gutierrez-Gonzalez, Brandon J. Dekosky, Kayla G. Sprenger, Timothy A. Whitehead
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable mAb sequences in silico could greatly reduce the time and cost required for therapeutic mA
Externí odkaz:
https://doaj.org/article/10a36cfa20ad4ada87c052c6b7e5c904
Autor:
Gwo-Yu Chuang, Chen-Hsiang Shen, Crystal Sao-Fong Cheung, Jason Gorman, Adrian Creanga, M. Gordon Joyce, Kwanyee Leung, Reda Rawi, Lingshu Wang, Eun Sung Yang, Yongping Yang, Baoshan Zhang, Yi Zhang, Masaru Kanekiyo, Tongqing Zhou, Brandon J. DeKosky, Barney S. Graham, John R. Mascola, Peter D. Kwong
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Sequence signatures of multidonor broadly neutralizing influenza antibodies can be used to quantify the prevalence of B cells with virus-neutralizing potential to accelerate development of broadly protective vaccine strategies. Antibodies of the same
Externí odkaz:
https://doaj.org/article/4fb75475a05a4cafaaad0d7a34c8aa43
Autor:
Aric Huang, Wei Jin, Ahmed S. Fahad, Brooklyn K. Mussman, Grazia Paola Nicchia, Bharat Madan, Matheus Oliveira de Souza, J. Daniel Griffin, Jeffrey L. Bennett, Antonio Frigeri, Cory J. Berkland, Brandon J. DeKosky
Publikováno v:
Antibodies, Vol 11, Iss 2, p 39 (2022)
A rapid and effective method to identify disease-specific antibodies from clinical patients is important for understanding autoimmune diseases and for the development of effective disease therapies. In neuromyelitis optica (NMO), the identification o
Externí odkaz:
https://doaj.org/article/59f3a6dc89844b95ad3e0160581a8e51
Autor:
Ahmed S. Fahad, Morgan R. Timm, Bharat Madan, Katherine E. Burgomaster, Kimberly A. Dowd, Erica Normandin, Matías F. Gutiérrez-González, Joseph M. Pennington, Matheus Oliveira De Souza, Amy R. Henry, Farida Laboune, Lingshu Wang, David R. Ambrozak, Ingelise J. Gordon, Daniel C. Douek, Julie E. Ledgerwood, Barney S. Graham, Leda R. Castilho, Theodore C. Pierson, John R. Mascola, Brandon J. DeKosky
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The re-emergence of Zika virus (ZIKV) caused widespread infections that were linked to Guillain-Barré syndrome in adults and congenital malformation in fetuses, and epidemiological data suggest that ZIKV infection can induce protective antibody resp
Externí odkaz:
https://doaj.org/article/f95e6840712f42789ca64171182a652b