Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Brandon J. Coombes"'
Autor:
Ming-Fen Ho, Cheng Zhang, Irene Moon, Mustafa Tuncturk, Brandon J. Coombes, Joanna Biernacka, Michelle Skime, Tyler S. Oesterle, Victor M. Karpyak, Hu Li, Richard Weinshilboum
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Alcohol use disorder (AUD) is the most prevalent substance use disorder worldwide. Acamprosate and naltrexone are anti-craving drugs used in AUD pharmacotherapy. However, molecular mechanisms underlying their anti-craving effect remain uncle
Externí odkaz:
https://doaj.org/article/733ec22160cf45808418177567760984
Autor:
Nicolas A. Nuñez, Brandon J. Coombes, Lindsay Melhuish Beaupre, Aysegul Ozerdem, Manuel Gardea Resendez, Francisco Romo-Nava, David J. Bond, Marin Veldic, Balwinder Singh, Katherine M. Moore, Hannah K. Betcher, Simon Kung, Miguel L. Prieto, Manuel Fuentes, Mete Ercis, Alessandro Miola, Jorge A. Sanchez Ruiz, Gregory Jenkins, Anthony Batzler, Jonathan G. Leung, Alfredo Cuellar-Barboza, Susannah J. Tye, Susan L. McElroy, Joanna M. Biernacka, Mark A. Frye
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-5 (2024)
Abstract There is increasing interest in individualizing treatment selection for more than 25 regulatory approved treatments for major depressive disorder (MDD). Despite an inconclusive efficacy evidence base, antidepressants (ADs) are prescribed for
Externí odkaz:
https://doaj.org/article/30895815cfaa4cdd8a949170cc6615ae
Autor:
Alessandro Miola, Manuel Gardea-Reséndez, Javier Ortiz-Orendain, Nicolas A. Nunez, Mete Ercis, Brandon J. Coombes, Manuel Fuentes Salgado, Peggy M. Gruhlke, Ian Michel, J. Michael Bostwick, Alastair J. McKean, Aysegul Ozerdem, Mark A. Frye
Publikováno v:
International Journal of Bipolar Disorders, Vol 11, Iss 1, Pp 1-8 (2023)
Abstract Background Factors associated with suicide attempts during the antecedent illness trajectory of bipolar disorder (BD) and schizophrenia (SZ) are poorly understood. Methods Utilizing the Rochester Epidemiology Project, individuals born after
Externí odkaz:
https://doaj.org/article/f836c32147f1485dacf2b9906f24bd21
Autor:
Manuel Gardea-Resendez, Javier Ortiz-Orendain, Alessandro Miola, Manuel Fuentes Salgado, Mete Ercis, Brandon J. Coombes, Peggy M. Gruhlke, J. Michael Bostwick, Ian Michel, Jennifer L. Vande Voort, Aysegul Ozerdem, Alastair McKean, Mark A. Frye, Monica Taylor-Desir
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
BackgroundThere is evidence suggesting racial disparities in diagnosis and treatment in bipolar disorder (BD) and schizophrenia (SZ). The purpose of this study is to compare psychiatric diagnoses and psychotropic use preceding a first episode of mani
Externí odkaz:
https://doaj.org/article/d01fa39f3320409c8c76cbdae6f57c6b
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Causal variants for rare genetic diseases are often rare in the general population. Rare variants may also contribute to common complex traits and can have much larger per-allele effect sizes than common variants, although power to detect these assoc
Externí odkaz:
https://doaj.org/article/1d9426eae2d5484c857319a827a32fd6
Autor:
Ming-Fen Ho, Cheng Zhang, Irene Moon, Brandon J. Coombes, Joanna Biernacka, Michelle Skime, Doo-Sup Choi, Paul E. Croarkin, Mark A. Frye, Quyen Ngo, Cedric Skillon, Tyler S. Oesterle, Victor M. Karpyak, Hu Li, Richard M. Weinshilboum
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Acamprosate is an anti-craving drug used in alcohol use disorder (AUD) pharmacotherapy. However, only a subset of patients achieves optimal treatment outcomes. The identification of predictive biomarkers of acamprosate treatment response in patients
Externí odkaz:
https://doaj.org/article/445a37043746454796c7800fa3f24d90
Autor:
Nicolas A. Nunez, Brandon J. Coombes, Francisco Romo-Nava, David J. Bond, Jennifer Vande Voort, Paul E. Croarkin, Nicole Leibman, Manuel Gardea Resendez, Marin Veldic, Hannah Betcher, Balwinder Singh, Colin Colby, Alfredo Cuellar-Barboza, Miguel Prieto, Katherine M. Moore, Aysegul Ozerdem, Susan L. McElroy, Mark A. Frye, Joanna M. Biernacka
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Background:Bipolar disorder (BD) with co-occurring attention deficit-hyperactivity disorder (ADHD) is associated with an unfavorable course of illness. We aimed to identify potential clinical and genetic correlates of BD with and without ADHD.Methods
Externí odkaz:
https://doaj.org/article/1eeb2279ff6440a9bb8be087b4191bc6
Autor:
Boney Joseph, Nicolas A. Nunez, Vanessa Pazdernik, Rakesh Kumar, Mehak Pahwa, Mete Ercis, Aysegul Ozerdem, Alfredo B. Cuellar-Barboza, Francisco Romo-Nava, Susan L. McElroy, Brandon J. Coombes, Joanna M. Biernacka, Marius N. Stan, Mark A. Frye, Balwinder Singh
Publikováno v:
Brain Sciences, Vol 13, Iss 1, p 133 (2023)
Lithium has been a cornerstone treatment for bipolar disorder (BD). Despite descriptions in the literature regarding associations between long-term lithium therapy (LTLT) and development of a thyroid disorder (overt/subclinical hypo/hyperthyroidism,
Externí odkaz:
https://doaj.org/article/42ded38a30ad48ee938c16402700f84e
Autor:
Alfredo B. Cuéllar-Barboza, Susan L. McElroy, Marin Veldic, Balwinder Singh, Simon Kung, Francisco Romo-Nava, Nicolas A. Nunez, Alejandra Cabello-Arreola, Brandon J. Coombes, Miguel Prieto, Hannah K. Betcher, Katherine M. Moore, Stacey J. Winham, Joanna M. Biernacka, Mark A. Frye
Publikováno v:
International Journal of Bipolar Disorders, Vol 8, Iss 1, Pp 1-17 (2020)
Abstract Background Treatment in bipolar disorder (BD) is commonly applied as a multimodal therapy based on decision algorithms that lack an integrative understanding of molecular mechanisms or a biomarker associated clinical outcome measure. Pharmac
Externí odkaz:
https://doaj.org/article/8aad87cd6dc64ddbb96b43f45b49089a
Autor:
Tamar Sofer, Jiwon Lee, Nuzulul Kurniansyah, Deepti Jain, Cecelia A. Laurie, Stephanie M. Gogarten, Matthew P. Conomos, Ben Heavner, Yao Hu, Charles Kooperberg, Jeffrey Haessler, Ramachandran S. Vasan, L. Adrienne Cupples, Brandon J. Coombes, Amanda Seyerle, Sina A. Gharib, Han Chen, Jeffrey R. O’Connell, Man Zhang, Daniel J. Gottlieb, Bruce M. Psaty, W.T. Longstreth, Jr., Jerome I. Rotter, Kent D. Taylor, Stephen S. Rich, Xiuqing Guo, Eric Boerwinkle, Alanna C. Morrison, James S. Pankow, Andrew D. Johnson, Nathan Pankratz, Alex P. Reiner, Susan Redline, Nicholas L. Smith, Kenneth M. Rice, Elizabeth D. Schifano
Publikováno v:
HGG Advances, Vol 2, Iss 3, Pp 100040- (2021)
Summary: Whole-genome sequencing (WGS) and whole-exome sequencing studies have become increasingly available and are being used to identify rare genetic variants associated with health and disease outcomes. Investigators routinely use mixed models to
Externí odkaz:
https://doaj.org/article/9717e25558f44cca97be5c08e407ddcf