A T cell-myeloid IL-10 axis regulates pathogenic IFN-γ-dependent immunity in a mouse model of type 2-low asthma

Autor: Branchett, W, Stoelting, H, Oliver, R, Walker, S, Puttur, F, Gregory, L, Gabrysova, L, Wilson, M, O'Garra, A, Lloyd, C

Publikováno v: 678.e9

Background Although originally defined as a type 2 (T2) immune-mediated condition, non-T2 cytokines, such as IFN-γ and IL-17A, have been implicated in asthma pathogenesis, particularly severe disease. IL-10 regulates T helper (Th) cell phenotypes an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::d6b3d20c40afbe77559ab57904478d9c
http://hdl.handle.net/10044/1/72992

Epithelial derived TGF-β1 acts as a pro-viral factor in the lung during influenza A infection

Autor: Denney, L, Branchett, W, Gregory, L, Oliver, R, Lloyd, CM

Mucosal surfaces are under constant bombardment from potentially antigenic particles and so must maintain a balance between homeostasis and inappropriate immune activation and consequent pathology. Epithelial cells have a vital role orchestrating pul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::6948a50c9f4502711c8ae078ff7670d2
http://hdl.handle.net/10044/1/50255

Derivation of ligands for the complement C3a receptor from the C-terminus of C5a

Autor: Halai, R., Bellows-Peterson, M.L., Branchett, W., Smadbeck, J., Kieslich, C.A., Croker, D.E., Cooper, M.A., Morikis, D., Woodruff, T.M., Floudas, C.A., Monk, P.N.

The complement cascade is a highly sophisticated network of proteins that are well regulated and directed in response to invading pathogens or tissue injury. Complement C3a and C5a are key mediators produced by this cascade, and their dysregulation h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::143019315e253eb4de6ba450c0b82e6d

Epithelial-derived TGF-ß1 acts as a pro-viral factor in the lung during influenza A infection

Autor: Denney, L, Branchett, W, Gregory, L G, Oliver, R A, Lloyd, C M

Publikováno v: Mucosal Immunology; March 2018, Vol. 11 Issue: 2 p523-535, 13p

Derivation of ligands for the complement C3a receptor from the C-terminus of C5a.

Autor: Halai R; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Bellows-Peterson ML; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA., Branchett W; Department of Infection and Immunity, Sheffield University Medical School, Sheffield, UK., Smadbeck J; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA., Kieslich CA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA; Department of Bioengineering, University of California, Riverside, CA, USA., Croker DE; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Cooper MA; Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia., Morikis D; Department of Bioengineering, University of California, Riverside, CA, USA., Woodruff TM; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia., Floudas CA; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA. Electronic address: floudas@Princeton.EDU., Monk PN; Department of Infection and Immunity, Sheffield University Medical School, Sheffield, UK. Electronic address: p.monk@shef.ac.uk.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2014 Dec 15; Vol. 745, pp. 176-81. Date of Electronic Publication: 2014 Oct 30.