Synthetic (N, N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs

Autor: Jeroen D. C. Codée, Branca C van Veen, Thomas Bruyning, Joey G C Vlaming, Dennis P A Wander, Thomas Hansen, Gijsbert A. van der Marel, Merijn B L Vriends, Jacques Neefjes, Sabina Y van der Zanden, Herman S. Overkleeft

Publikováno v: The Journal of Organic Chemistry
Wander, D P A, Van Der Zanden, S Y, Vriends, M B L, Van Veen, B C, Vlaming, J G C, Bruyning, T, Hansen, T, Van Der Marel, G A, Overkleeft, H S, Neefjes, J J C & Codée, J D C 2021, ' Synthetic (N, N-Dimethyl)doxorubicin Glycosyl Diastereomers to Dissect Modes of Action of Anthracycline Anticancer Drugs ', The Journal of organic chemistry, vol. 86, no. 8, pp. 5757-5770 . https://doi.org/10.1021/acs.joc.1c00220
Journal of Organic Chemistry
Journal of Organic Chemistry, 86(8), 5757-5770. American Chemical Society ({ACS})
Journal of Organic Chemistry, 86(8), 5757-5770. AMER CHEMICAL SOC
The Journal of organic chemistry, 86(8), 5757-5770. American Chemical Society

Anthracyclines are effective drugs in the treatment of various cancers, but their use comes with severe side effects. The archetypal anthracycline drug, doxorubicin, displays two molecular modes of action: DNA double-strand break formation (through t

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