Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Branavan, Manoranjan"'
Autor:
Branavan Manoranjan, Chitra Venugopal, David Bakhshinyan, Ashley A. Adile, Laura Richards, Michelle M. Kameda-Smith, Owen Whitley, Anna Dvorkin-Gheva, Minomi Subapanditha, Neil Savage, Nazanin Tatari, Dillon McKenna, Blessing Bassey-Archibong, Neil Winegarden, Robin Hallett, John P. Provias, Blake Yarascavitch, Olufemi Ajani, Adam Fleming, Gary D. Bader, Trevor J. Pugh, Bradley W. Doble, Sheila K. Singh
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The Wnt molecular subgroup of medulloblastoma is associated with better prognosis than the other molecular subgroups. Here, the authors show that activating Wnt signaling impairs tumor development and improves survival in Group 3 and Group 4 medullob
Externí odkaz:
https://doaj.org/article/90b86d3d0f9c41078f2e0a70337929d5
Autor:
Branavan Manoranjan, MD, PhD, Yves P. Starreveld, MD, PhD, Robert A. Nordal, MSC, MD, FRCPC, Christopher Dunham, MD, FRCPC, Susanne Bens, MD, Christian Thomas, MD, Martin Hasselblatt, MD, Jeffrey T. Joseph, MD, PhD
Publikováno v:
Free Neuropathology, Vol 2 (2021)
We present a young adult woman who developed a myxoid tumor of the pineal region having a SMARCB1 mutation, which was phenotypically similar to the recently described desmoplastic myxoid, SMARCB1-mutant tumor of the pineal region (DMT-SMARCB1). The 2
Externí odkaz:
https://doaj.org/article/fff7e7e268b8466db7167647569f68de
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effect
Externí odkaz:
https://doaj.org/article/9abd25ef9a0545b4af3e3908c09df06e
Autor:
David, Ben-Israel, Jennifer A, Mann, Michael M H, Yang, Albert M, Isaacs, Magalie, Cadieux, Nicholas, Sader, Sandeep, Muram, Abdulrahman, Albakr, Branavan, Manoranjan, Richard W, Yu, Benjamin, Beland, Mark G, Hamilton, Eldon, Spackman, Paul E, Ronksley, Jay, Riva-Cambrin
Publikováno v:
Journal of Neurosurgery: Pediatrics. 30:18-30
OBJECTIVE Endoscopic third ventriculostomy and choroid plexus cauterization (ETV+CPC) is a novel procedure for infant hydrocephalus that was developed in sub-Saharan Africa to mitigate the risks associated with permanent implanted shunt hardware. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701744b2527bf76d4e79fe9f2f4170c9
https://doi.org/10.3171/2022.3.peds21512
https://doi.org/10.3171/2022.3.peds21512
Autor:
Sheila K. Singh, John A. Hassell, Mickie Bhatia, Bradley W. Doble, Naresh K. Murty, Kesava Reddy, John P. Provias, Boleslaw Lach, Thusyanth Vijayakumar, Neha Garg, David Bakhshinyan, Mohini Singh, Sara M. Nolte, Minomi Subapanditha, Nicole McFarlane, Maleeha A. Qazi, Sujeivan Mahendram, Branavan Manoranjan, Parvez Vora, Robin Hallett, Chitra Venugopal
Supplementary Tables 1-6. Supplementary Table 1: Clinico-pathological demographics of CD133high and CD133low GBM; Supplementary Table 2: Positive and negative correlation probe sets present in CD133-signature; Supplementary Table 3: Drug targets acqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de78838d7c2f0c5240df40b3287c5a4a
https://doi.org/10.1158/1078-0432.22461183
https://doi.org/10.1158/1078-0432.22461183
Autor:
Sheila K. Singh, John A. Hassell, Mickie Bhatia, Bradley W. Doble, Naresh K. Murty, Kesava Reddy, John P. Provias, Boleslaw Lach, Thusyanth Vijayakumar, Neha Garg, David Bakhshinyan, Mohini Singh, Sara M. Nolte, Minomi Subapanditha, Nicole McFarlane, Maleeha A. Qazi, Sujeivan Mahendram, Branavan Manoranjan, Parvez Vora, Robin Hallett, Chitra Venugopal
Supplementary Figures 1-6. Supplementary Figure 1: CD133 correlates patient outcome with GIC selfrenewal and proliferative capacities in human GBM; Supplementary Figure 2: Gene Set Enrichment Analysis (GSEA) results for embryonic stem cell gene sets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681815f4a53c686ab94a8ae9200b1e5d
https://doi.org/10.1158/1078-0432.22461186.v1
https://doi.org/10.1158/1078-0432.22461186.v1
Autor:
Sheila K. Singh, John A. Hassell, Mickie Bhatia, Bradley W. Doble, Naresh K. Murty, Kesava Reddy, John P. Provias, Boleslaw Lach, Thusyanth Vijayakumar, Neha Garg, David Bakhshinyan, Mohini Singh, Sara M. Nolte, Minomi Subapanditha, Nicole McFarlane, Maleeha A. Qazi, Sujeivan Mahendram, Branavan Manoranjan, Parvez Vora, Robin Hallett, Chitra Venugopal
Purpose: Clonal evolution of cancer may be regulated by determinants of stemness, specifically self-renewal, and current therapies have not considered how genetic perturbations or properties of stemness affect such functional processes. Glioblastoma-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd1dfd8b7def7e3e289f754346e8c43
https://doi.org/10.1158/1078-0432.c.6524712
https://doi.org/10.1158/1078-0432.c.6524712
Autor:
Sandra E. Dunn, Christopher Dunham, Sheila K. Singh, Paul Northcott, Stephen Yip, Rod Rassekh, Juliette Hukin, Ash Singhal, Michael D. Taylor, Eric Bouffet, Vijay Ramaswamy, Cynthia Hawkins, Aru Narendran, Katrina O'Halloran, Chitra Venugopal, Abbas Fotovati, Rachel Berns, Mary Rose Pambid, Branavan Manoranjan, Colleen Foster, Cathy Lee, Joanna Triscott
Medulloblastoma is the most common malignant brain tumor in children. This disease is heterogeneous and is composed of four subtypes of medulloblastoma [WNT, Sonic Hedgehog (SHH), Group 3, and Group 4]. An immediate goal is to identify novel molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2676c0f11180d32a7b8ade9835657025
https://doi.org/10.1158/0008-5472.c.6505601
https://doi.org/10.1158/0008-5472.c.6505601
Autor:
Sandra E. Dunn, Christopher Dunham, Sheila K. Singh, Paul Northcott, Stephen Yip, Rod Rassekh, Juliette Hukin, Ash Singhal, Michael D. Taylor, Eric Bouffet, Vijay Ramaswamy, Cynthia Hawkins, Aru Narendran, Katrina O'Halloran, Chitra Venugopal, Abbas Fotovati, Rachel Berns, Mary Rose Pambid, Branavan Manoranjan, Colleen Foster, Cathy Lee, Joanna Triscott
PDF file - 80K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1105923776f2fa6159acbf1c2f1d4367
https://doi.org/10.1158/0008-5472.22400492.v1
https://doi.org/10.1158/0008-5472.22400492.v1
Autor:
Sandra E. Dunn, Christopher Dunham, Sheila K. Singh, Paul Northcott, Stephen Yip, Rod Rassekh, Juliette Hukin, Ash Singhal, Michael D. Taylor, Eric Bouffet, Vijay Ramaswamy, Cynthia Hawkins, Aru Narendran, Katrina O'Halloran, Chitra Venugopal, Abbas Fotovati, Rachel Berns, Mary Rose Pambid, Branavan Manoranjan, Colleen Foster, Cathy Lee, Joanna Triscott
PDF file - 685K, Supplementary Table S1. Summary of the pediatric MB patients included in the study Discovery cohort. Supplementary Table S2. Summary of the pediatric MB patients included in the study Validation cohort. Supplementary Table S3. PAM cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a19d6b4ff4989b69f799a74f683b628
https://doi.org/10.1158/0008-5472.22400489
https://doi.org/10.1158/0008-5472.22400489