Genome-wide CRISPR screens reveal Hippo pathway activation as a resistance mechanism in BRAF mutant colon cancer

Autor: Brammeld, Js, Thorpe, H, Garcia, Ma, Price, S, Young, J, Pfeifer, M, Lupo, B, Yusa, K, Trusolino, L, Garnett, M, Bertotti, A, Bakal, C, Mcdermott, U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______970::f12cc606bcaf8ab2328006485beff63e
https://hdl.handle.net/2318/1885603

Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.

Autor: Petljak M; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Alexandrov LB; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK; Department of Cellular and Molecular Medicine and Department of Bioengineering, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., Brammeld JS; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Price S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Wedge DC; Oxford Big Data Institute, Old Road Campus, Oxford OX3 7LF, UK; Oxford NIHR Biomedical Research Centre, Oxford, OX4 2PG, UK., Grossmann S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Dawson KJ; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Ju YS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea., Iorio F; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK; European Molecular Biology Laboratory - European Bioinformatics Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Tubio JMC; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK; Mobile Genomes and Disease, Molecular Medicine and Chronic Diseases Centre (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain; Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain; The Biomedical Research Centre (CINBIO), Universidade de Vigo, Vigo 36310, Spain., Koh CC; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Georgakopoulos-Soares I; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Rodríguez-Martín B; Mobile Genomes and Disease, Molecular Medicine and Chronic Diseases Centre (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain; Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain; The Biomedical Research Centre (CINBIO), Universidade de Vigo, Vigo 36310, Spain., Otlu B; Department of Cellular and Molecular Medicine and Department of Bioengineering, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA., O'Meara S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Butler AP; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Menzies A; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Bhosle SG; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Raine K; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Jones DR; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Teague JW; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Beal K; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Latimer C; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., O'Neill L; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Zamora J; Mobile Genomes and Disease, Molecular Medicine and Chronic Diseases Centre (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain; Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain; The Biomedical Research Centre (CINBIO), Universidade de Vigo, Vigo 36310, Spain., Anderson E; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Patel N; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Maddison M; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Ng BL; Cytometry Core Facility, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Graham J; Cytometry Core Facility, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Garnett MJ; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., McDermott U; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Nik-Zainal S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK; Department of Medical Genetics, The Clinical School, University of Cambridge, Cambridge, CB2 0QQ, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK., Stratton MR; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK. Electronic address: mrs@sanger.ac.uk.

Publikováno v: Cell [Cell] 2019 Mar 07; Vol. 176 (6), pp. 1282-1294.e20.

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Autor: Brammeld JS; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Petljak M; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Martincorena I; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Williams SP; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Alonso LG; European Molecular Biology Laboratory - European Bioinformatics Institute, Cambridge CB10 1SA, United Kingdom., Dalmases A; Pathology Department, Hospital del Mar, 08003 Barcelona, Spain., Bellosillo B; Pathology Department, Hospital del Mar, 08003 Barcelona, Spain., Robles-Espinoza CD; Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus Juriquilla, Santiago de Querétaro 76230, Mexico., Price S; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Barthorpe S; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Tarpey P; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Alifrangis C; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Bignell G; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Vidal J; Cancer Research Program, FIMIM and Medical Oncology Department, Hospital del Mar, 08003 Barcelona, Spain., Young J; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Stebbings L; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Beal K; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Stratton MR; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Saez-Rodriguez J; European Molecular Biology Laboratory - European Bioinformatics Institute, Cambridge CB10 1SA, United Kingdom.; RWTH Aachen University Hospital, 52062 Aachen, Germany., Garnett M; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom., Montagut C; Cancer Research Program, FIMIM and Medical Oncology Department, Hospital del Mar, 08003 Barcelona, Spain., Iorio F; European Molecular Biology Laboratory - European Bioinformatics Institute, Cambridge CB10 1SA, United Kingdom., McDermott U; Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom.

Publikováno v: Genome research [Genome Res] 2017 Apr; Vol. 27 (4), pp. 613-625. Date of Electronic Publication: 2017 Feb 08.