Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation in severe disease

Autor: Jose Ordovas-Montanes, Travis K. Hughes, Paul Kelly, Simutanyi Mwakamui, Alex K. Shalek, Uchida Am, Benjamin Doran, Zev J. Gartner, Bramante Jt, Marko Vukovic, Nolawit Mulugeta, Kanekwa Zyambo, Ira Fleming, Wallach T, Kummerlowe C, Garber Jj, Ellen Besa, Mudenda

Environmental enteropathy (EE) is a subclinical condition of the small intestine that is highly prevalent in low- and middle-income countries. It is thought to be a key contributing factor to childhood malnutrition, growth-stunting, and diminished or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58504ee1b85788c9617aeb1fe3bb97d4
https://doi.org/10.1101/2021.04.11.439202

HIV-associated gut microbial alterations are dependent on host and geographic context.

Autor: Rocafort M; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA., Gootenberg DB; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA.; Harvard Medical School, Boston, MA, 02114, USA., Luévano JM Jr; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA.; Harvard Medical School, Boston, MA, 02114, USA., Paer JM; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA., Hayward MR; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA., Bramante JT; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA., Ghebremichael MS; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA., Xu J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA., Rogers ZH; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA., Munoz AR; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA., Okello S; Department of Medicine, Mbarara University of Science and Technology, 1956, Mbarara, Uganda., Kim JH; Harvard Medical School, Boston, MA, 02114, USA., Sentongo R; Department of Medicine, Mbarara University of Science and Technology, 1956, Mbarara, Uganda., Wagubi R; Department of Medicine, Mbarara University of Science and Technology, 1956, Mbarara, Uganda., Lankowski A; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, 02114, USA., Maruapula S; Department of Family & Consumer Sciences, University of Botswana, 0022, Gaborone, Botswana., Zhao G; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Handley SA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Mosepele M; Faculty of Medicine, University of Botswana, 0022, Gaborone, Botswana., Siedner MJ; Harvard Medical School, Boston, MA, 02114, USA.; Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, 02114, USA.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, 02114, USA., Kwon DS; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02139, USA. dkwon@mgh.harvard.edu.; Harvard Medical School, Boston, MA, 02114, USA. dkwon@mgh.harvard.edu.; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, 02114, USA. dkwon@mgh.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Feb 05; Vol. 15 (1), pp. 1055. Date of Electronic Publication: 2024 Feb 05.

Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation.

Autor: Kummerlowe C; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mwakamui S; Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia., Hughes TK; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mulugeta N; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mudenda V; Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia., Besa E; Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia., Zyambo K; Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia., Shay JES; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA., Fleming I; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Vukovic M; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Doran BA; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Pathology, MGH, Harvard Medical School, Boston, MA 02115, USA., Aicher TP; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wadsworth MH 2nd; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Bramante JT; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Department of Pathology, MGH, Harvard Medical School, Boston, MA 02115, USA.; University of Washington School of Medicine, Seattle, WA 98195, USA., Uchida AM; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.; Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Fardoos R; Africa Health Research Institute, Durban 4001, South Africa., Asowata OE; Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, 02115, USA.; Africa Health Research Institute, Durban 4001, South Africa.; Center for Biomedical Research, Population Council, Rockefeller University, New York, NY 10065, USA., Herbert N; Africa Health Research Institute, Durban 4001, South Africa., Yilmaz ÖH; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Pathology, MGH, Harvard Medical School, Boston, MA 02115, USA., Kløverpris HN; Africa Health Research Institute, Durban 4001, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.; Department of Immunology and Microbiology, University of Copenhagen, 1017 Copenhagen K, Denmark.; University College London, Division of Infection and Immunity, London WC1E 6BT, UK., Garber JJ; Department of Pathology, MGH, Harvard Medical School, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Ordovas-Montañes J; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, USA.; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA.; Harvard Stem Cell Institute, Cambridge, MA 02138, USA., Gartner ZJ; University of California San Francisco, San Francisco, CA 94185, USA.; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA., Wallach T; Department of Pediatrics, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA., Shalek AK; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Institute for Medical Engineering and Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA., Kelly P; Tropical Gastroenterology and Nutrition Group, University of Zambia School of Medicine, Lusaka, Zambia.; Blizard Institute, Queen Mary University of London, London E1 2AT, UK.

Publikováno v: Science translational medicine [Sci Transl Med] 2022 Aug 31; Vol. 14 (660), pp. eabi8633. Date of Electronic Publication: 2022 Aug 31.

Community-acquired in name only: A cluster of carbapenem-resistant Acinetobacter baumannii in a burn intensive care unit and beyond.

Autor: Shenoy ES; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.; Infection Control Unit, Massachusetts General Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts., Pierce VM; Division of Pathology, Massachusetts General Hospital, Boston, Massachusetts.; Pediatric Infectious Disease Unit, MassGeneral Hospital for Children, Boston, Massachusetts.; Department of Pathology, Harvard Medical School, Boston, Massachusetts., Sater MRA; Day Zero Diagnostics, Boston, Massachusetts., Pangestu FK; Day Zero Diagnostics, Boston, Massachusetts., Herriott IC; Day Zero Diagnostics, Boston, Massachusetts., Anahtar MN; Division of Pathology, Massachusetts General Hospital, Boston, Massachusetts.; Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Bramante JT; Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Kwon DS; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.; Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Hawkins FR; Infection Control Unit, Massachusetts General Hospital, Boston, Massachusetts., Suslak D; Infection Control Unit, Massachusetts General Hospital, Boston, Massachusetts., West LR; Infection Control Unit, Massachusetts General Hospital, Boston, Massachusetts., Huntley MH; Day Zero Diagnostics, Boston, Massachusetts., Hooper DC; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.; Infection Control Unit, Massachusetts General Hospital, Boston, Massachusetts.; Department of Medicine, Harvard Medical School, Boston, Massachusetts.

Publikováno v: Infection control and hospital epidemiology [Infect Control Hosp Epidemiol] 2020 May; Vol. 41 (5), pp. 531-538. Date of Electronic Publication: 2020 Feb 28.