Výsledky vyhledávání - "Bram Weytjens"

Akademický článek

Image-Based Dynamic Phenotyping Reveals Genetic Determinants of Filamentation-Mediated β-Lactam Tolerance

Autor: Taiyeb Zahir, Dorien Wilmaerts, Sabine Franke, Bram Weytjens, Rafael Camacho, Kathleen Marchal, Johan Hofkens, Maarten Fauvart, Jan Michiels

Publikováno v: Frontiers in Microbiology, Vol 11 (2020)

Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance. β-lactam antibiotics inhibit cell wall growth in bacteria and many of them cause filamentatio

Externí odkaz: https://doaj.org/article/c11f7fce17ad4a039ea86195165c54af

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Akademický článek

1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage

Autor: Valerie Defraine, Veerle Liebens, Evelien Loos, Toon Swings, Bram Weytjens, Carolina Fierro, Kathleen Marchal, Liam Sharkey, Alex J. O’Neill, Romu Corbau, Arnaud Marchand, Patrick Chaltin, Maarten Fauvart, Jan Michiels

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

The ever increasing multidrug-resistance of clinically important pathogens and the lack of novel antibiotics have resulted in a true antibiotic crisis where many antibiotics are no longer effective. Further complicating the treatment of bacterial inf

Externí odkaz: https://doaj.org/article/3a312b1dedc148f7bfd3d5bebb78855a

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Akademický článek

Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa.

Autor: Evelien Gerits, Eline Blommaert, Anna Lippell, Alex J O'Neill, Bram Weytjens, Dries De Maeyer, Ana Carolina Fierro, Kathleen Marchal, Arnaud Marchand, Patrick Chaltin, Pieter Spincemaille, Katrijn De Brucker, Karin Thevissen, Bruno P A Cammue, Toon Swings, Veerle Liebens, Maarten Fauvart, Natalie Verstraeten, Jan Michiels

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155139 (2016)

Nosocomial and community-acquired infections caused by multidrug resistant bacteria represent a major human health problem. Thus, there is an urgent need for the development of antibiotics with new modes of action. In this study, we investigated the

Externí odkaz: https://doaj.org/article/7817d195d5314e5da71bb79f9598c0f1

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OMEN: network-based driver gene identification using mutual exclusivity

Autor: Dries Van Daele, Bram Weytjens, Luc De Raedt, Kathleen Marchal

Publikováno v: Bioinformatics. 38:3245-3251

Motivation Network-based driver identification methods that can exploit mutual exclusivity typically fail to detect rare drivers because of their statistical rigor. Propagation-based methods in contrast allow recovering rare driver genes, but the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a85c81c5aa3820e4f95018b6689d58
https://doi.org/10.1093/bioinformatics/btac312

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IAMBEE: a web-service for the identification of adaptive pathways from parallel evolved clonal populations

Autor: Dries De Maeyer, Toon Swings, Jan Michiels, Dries Decap, Bram Weytjens, Camilo Andres Perez-Romero, Kathleen Marchal

Publikováno v: NUCLEIC ACIDS RESEARCH
Nucleic Acids Research

IAMBEE is a web server designed for the Identification of Adaptive Mutations in Bacterial Evolution Experiments (IAMBEE). Input data consist of genotype information obtained from independently evolved clonal populations or strains that show the same

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d478c5b65463545e97d0d710b64521c
https://doi.org/10.1093/nar/gkz451

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Network-Based Identification of Adaptive Pathways in Evolved Ethanol-Tolerant Bacterial Populations

Autor: Toon Swings, Bram Weytjens, Natalie Verstraeten, Jan Michiels, Kathleen Marchal, Thomas Schalck, Camille Bonte

Publikováno v: Molecular Biology and Evolution
MOLECULAR BIOLOGY AND EVOLUTION

Efficient production of ethanol for use as a renewable fuel requires organisms with a high level of ethanol tolerance. However, this trait is complex and increased tolerance therefore requires mutations in multiple genes and pathways. Here, we use ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4637954bb6d0d98c247e5d67bb43df6b
http://europepmc.org/articles/PMC5850225

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1-((2,4-Dichlorophenethyl)Amino)3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)
FRONTIERS IN MICROBIOLOGY
Frontiers in Microbiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34654efeedd23d8b0df15eab46d71766
https://lirias.kuleuven.be/handle/123456789/621341

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Molecular processes underlying synergistic linuron mineralization in a triple-species bacterial consortium biofilm revealed by differential transcriptomics

Autor: Pieter Albers, Kathleen Marchal, René De Mot, Dirk Springael, Bram Weytjens

Publikováno v: MicrobiologyOpen
MICROBIOLOGYOPEN

The proteobacteria Variovorax sp. WDL1, Comamonas testosteroni WDL7, and Hyphomicrobium sulfonivorans WDL6 compose a triple-species consortium that synergistically degrades and grows on the phenylurea herbicide linuron. To acquire a better insight in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f0137cbceb06f29ebdbe90d9b5da21
https://lirias.kuleuven.be/handle/123456789/625674

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PheNetic: network-based interpretation of molecular profiling data

Autor: Dries De Maeyer, Kathleen Marchal, Luc De Raedt, Joris Renkens, Bram Weytjens

Publikováno v: Nucleic Acids Research
NUCLEIC ACIDS RESEARCH

Molecular profiling experiments have become standard in current wet-lab practices. Classically, enrichment analysis has been used to identify biological functions related to these experimental results. Combining molecular profiling results with the w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70f674d2a567aa452805a6c8ae6acb7
https://doi.org/10.1093/nar/gkv347

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Network-Based Analysis of eQTL Data to Prioritize Driver Mutations

Autor: Dries De Maeyer, Luc De Raedt, Bram Weytjens, Kathleen Marchal

Publikováno v: Genome Biology and Evolution
GENOME BIOLOGY AND EVOLUTION

In clonal systems, interpreting driver genes in terms of molecular networks helps understanding how these drivers elicit an adaptive phenotype. Obtaining such a network-based understanding depends on the correct identification of driver genes. In clo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc3d116337731d18e5614c2be99f465
https://pubmed.ncbi.nlm.nih.gov/26802430

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