Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Bram Thijssen"'
Autor:
Tessa G. Steenbruggen, Denise M. Wolf, Michael J. Campbell, Joyce Sanders, Sten Cornelissen, Bram Thijssen, Roberto A. Salgado, Christina Yau, Nick O-Grady, Amrita Basu, Rajith Bhaskaran, Lorenza Mittempergher, Gillian L. Hirst, Jean-Philippe Coppe, Marleen Kok, Gabe S. Sonke, Laura J. van ‘t Veer, Hugo M. Horlings
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-19 (2023)
Abstract Background Despite major improvements in treatment of HER2-positive metastatic breast cancer (MBC), only few patients achieve complete remission and remain progression free for a prolonged time. The tumor immune microenvironment plays an imp
Externí odkaz:
https://doaj.org/article/cd4ee360474c49639be138517e337159
Autor:
Mathilde M. M. Almekinders, Michael Schaapveld, Bram Thijssen, Lindy L. Visser, Tycho Bismeijer, Joyce Sanders, Edoardo Isnaldi, Ingrid Hofland, Marjolijn Mertz, Lodewyk F. A. Wessels, Annegien Broeks, Erik Hooijberg, Wilbert Zwart, Esther H. Lips, Grand Challenge PRECISION Consortium, Christine Desmedt, Jelle Wesseling
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-10 (2021)
Abstract Although ductal carcinoma in situ (DCIS) is a non-obligate precursor to ipsilateral invasive breast cancer (iIBC), most DCIS lesions remain indolent. Hence, overdiagnosis and overtreatment of DCIS is a major concern. There is an urgent need
Externí odkaz:
https://doaj.org/article/0a52b05e321f481ea6b0d325da202d72
Autor:
Fleur Jochems, Bram Thijssen, Giulia De Conti, Robin Jansen, Ziva Pogacar, Kelvin Groot, Liqin Wang, Arnout Schepers, Cun Wang, Haojie Jin, Roderick L. Beijersbergen, Rodrigo Leite de Oliveira, Lodewyk F.A. Wessels, René Bernards
Publikováno v:
Cell Reports, Vol 36, Iss 4, Pp 109441- (2021)
Summary: Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different i
Externí odkaz:
https://doaj.org/article/e5885b546531426bb7c25ec795372518
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-17 (2019)
Abstract Background HER2-driven breast cancer is correlated with poor prognosis, especially during its later stages. Numerous studies have shown the importance of the integrin α3β1 during the initiation and progression of breast cancer; however, it
Externí odkaz:
https://doaj.org/article/dd1231d9924449aa9fb087bb9b11b4d5
Autor:
Bram Thijssen, Lodewyk F A Wessels
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230101 (2020)
An important feature of Bayesian statistics is the opportunity to do sequential inference: the posterior distribution obtained after seeing a dataset can be used as prior for a second inference. However, when Monte Carlo sampling methods are used for
Externí odkaz:
https://doaj.org/article/1aa612b8d5d94374a6b4d304812c6986
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 7, p e1003119 (2013)
To investigate factors contributing to drug side effects, we systematically examine relationships between 4,199 side effects associated with 996 drugs and their 647 human protein targets. We find that it is the number of essential targets, not the nu
Externí odkaz:
https://doaj.org/article/f9d9ac20b40f4b80922a786093c5ebb4
Autor:
Lodewyk F.A. Wessels, Roderick L. Beijersbergen, Ian J. Majewski, Klaas de Lint, Roelof J.C. Kluin, Bram Thijssen, Katarzyna Jastrzebski
This file contains Supplementary Tables 2-8, 13 and 14: Supplementary Table 2: Cell line doubling times estimated from growth curves of confluence measurements. Supplementary Table 3: Normalized dose response data for each of the seven kinase inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a27331f732390ad7c2fc94ee44c1a4e
https://doi.org/10.1158/0008-5472.22418705.v1
https://doi.org/10.1158/0008-5472.22418705.v1
Autor:
Lodewyk F.A. Wessels, Roderick L. Beijersbergen, Ian J. Majewski, Klaas de Lint, Roelof J.C. Kluin, Bram Thijssen, Katarzyna Jastrzebski
This document contains Supplementary Materials & Methods including a mathematical specification of the model, as well as Supplementary Note 1 (Inferred signaling estimates agree with on-treatment phosphorylation measurements), Supplementary Note 2 (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509ac24fa1e83d9aeb09c231791d7ecc
https://doi.org/10.1158/0008-5472.22418714.v1
https://doi.org/10.1158/0008-5472.22418714.v1
Autor:
Lodewyk F.A. Wessels, Roderick L. Beijersbergen, Ian J. Majewski, Klaas de Lint, Roelof J.C. Kluin, Bram Thijssen, Katarzyna Jastrzebski
Cancer cell lines differ greatly in their sensitivity to anticancer drugs as a result of different oncogenic drivers and drug resistance mechanisms operating in each cell line. Although many of these mechanisms have been discovered, it remains a chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c5ae803bb34878197aa361d4edf29e
https://doi.org/10.1158/0008-5472.c.6510206
https://doi.org/10.1158/0008-5472.c.6510206
Autor:
Lodewyk F.A. Wessels, Roderick L. Beijersbergen, Ian J. Majewski, Klaas de Lint, Roelof J.C. Kluin, Bram Thijssen, Katarzyna Jastrzebski
This archive contains all files necessary for running the inference in BCM, including the models in BCM model specification format, processed data and configuration files. The archive also contains graphs of each of the inference results, including p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fe6d28ca870a961cd656f0516fe9db
https://doi.org/10.1158/0008-5472.22418717.v1
https://doi.org/10.1158/0008-5472.22418717.v1