Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bram Piersma"'
Autor:
Sophie A. Riesmeijer, Zoha Kamali, Michael Ng, Dmitriy Drichel, Bram Piersma, Kerstin Becker, Thomas B. Layton, Jagdeep Nanchahal, Michael Nothnagel, Ahmad Vaez, Hans Christian Hennies, Paul M. N. Werker, Dominic Furniss, Ilja M. Nolte
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Dupuytren’s disease (DD) is a highly heritable fibrotic disorder of the hand with incompletely understood etiology. A number of genetic loci, including Wnt signaling members, have been previously identified. Our overall aim was to identify
Externí odkaz:
https://doaj.org/article/1f6a94e13ec342bd8fe591da7584d1c3
Autor:
Nataly Puerta Cavanzo, Sophie A. Riesmeijer, Iris L. Holt-Kedde, Paul M. N. Werker, Bram Piersma, Peter Olinga, Ruud A. Bank
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Dupuytren’s disease is a chronic, progressive fibroproliferative condition of the hand fascia which results in digital contraction. So far, treatments do not directly interfere with the (myo)fibroblasts that are responsible for the formati
Externí odkaz:
https://doaj.org/article/686b76e24d904eaaaf0d16754775ab61
Autor:
Ruud A. Bank, Bram Piersma
Publikováno v:
Essays in Biochemistry. 63:377-387
The hallmark of fibrosis is an excessive accumulation of collagen, ultimately leading to organ failure. It has become evident that the deposited collagen also exhibits qualitative modifications. A marked modification is the increased cross-linking, l
Autor:
Emilia Bigaeva, Miriam Boersema, Bram Piersma, Lutz Wollin, Henricus A. M. Mutsaers, Anna M. Leliveld, Peter Olinga, Elisabeth G. D. Stribos, Marc A. Seelen, Harry van Goor, Igle J. de Jong, Ruud A. Bank
Publikováno v:
American journal of physiology-Renal physiology, 318(1), F117-F134. AMER PHYSIOLOGICAL SOC
Bigaeva, E, Stribos, E G D, Mutsaers, H A M, Piersma, B, Leliveld, A M, de Jong, I J, Bank, R A, Seelen, M A, van Goor, H, Wollin, L, Olinga, P & Boersema, M 2020, ' Inhibition of tyrosine kinase receptor signaling attenuates fibrogenesis in an ex vivo model of human renal fibrosis ', American Journal of Physiology-Renal Physiology, vol. 318, no. 1, pp. F117-F134 . https://doi.org/10.1152/ajprenal.00108.2019
Bigaeva, E, Stribos, E G D, Mutsaers, H A M, Piersma, B, Leliveld, A M, de Jong, I J, Bank, R A, Seelen, M A, van Goor, H, Wollin, L, Olinga, P & Boersema, M 2020, ' Inhibition of tyrosine kinase receptor signaling attenuates fibrogenesis in an ex vivo model of human renal fibrosis ', American Journal of Physiology-Renal Physiology, vol. 318, no. 1, pp. F117-F134 . https://doi.org/10.1152/ajprenal.00108.2019
Poor translation from animal studies to human clinical trials is one of the main hurdles in the development of new drugs. Here, we used precision-cut kidney slices (PCKS) as a translational model to study renal fibrosis and to investigate whether inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb5cd9a46bdec0031c19bb4746b6a77
https://research.rug.nl/en/publications/d559f867-9a02-4f05-94f4-9945138495be
https://research.rug.nl/en/publications/d559f867-9a02-4f05-94f4-9945138495be
Publikováno v:
Cell and Tissue Research
Mechanosensing of fibroblasts plays a key role in the development of fibrosis. So far, no effective treatments are available to treat this devastating disorder. Spectrins regulate cell morphology and are potential mechanosensors in a variety of non-e
Autor:
Paul M N Werker, Bram Piersma, Ruud A. Bank, Boris Hinz, Saskia de Rond, Stellar Boo, Marike van Beuge
Publikováno v:
The American Journal of Pathology, 185(12), 3326-3337. ELSEVIER SCIENCE INC
Dupuytren disease is a fibrotic disorder characterized by contraction of myofibroblast-rich cords and nodules in the hands. The Hippo member Yes-associated protein 1 (YAP1) is activated by tissue stiffness and the profibro tic transforming growth fac
Autor:
Bram Piersma, Ruud A. Bank
Publikováno v:
American Journal of Physiology-Cell Physiology, 312(3), C274-C276. AMER PHYSIOLOGICAL SOC
fibrosis in vital organs causes significant morbidity and mortality worldwide. Although our understanding of the cellular and molecular mechanisms underlying fibrosis has grown tremendously over the last decades, effective treatments that halt, rever
Publikováno v:
Biochimica et biophysica acta. Reviews on cancer, vol 1873, iss 2
Biochim Biophys Acta Rev Cancer
Biochim Biophys Acta Rev Cancer
Tumors are characterized by extracellular matrix (ECM) deposition, remodeling, and cross-linking that drive fibrosis to stiffen the stroma and promote malignancy. The stiffened stroma enhances tumor cell growth, survival and migration and drives a me
Autor:
Bram Piersma, Rutger A. F. Gjaltema, Ruud A. Bank, Saskia de Rond, Olaf Y. Wouters, Miriam Boersema
Publikováno v:
Physiological Reports, 5(17):e13324. Wiley
l-Ascorbic acid (AA), generally known as vitamin C, is a crucial cofactor for a variety of enzymes, including prolyl-3-hydroxylase (P3H), prolyl-4-hydroxylase (P4H), and lysyl hydroxylase (LH)-mediated collagen maturation. Here, we investigated wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f43f788e817b5b67da8e50e328a08b8
https://research.rug.nl/en/publications/4ac5aa7b-8c59-46b9-8270-5c910099db84
https://research.rug.nl/en/publications/4ac5aa7b-8c59-46b9-8270-5c910099db84
Publikováno v:
Frontiers in Medicine
Frontiers in Medicine, Vol 2 (2015)
Frontiers in Medicine, Vol 2 (2015)
Chronic organ injury leads to fibrosis and eventually organ failure. Fibrosis is characterized by excessive synthesis, remodeling, and contraction of extracellular matrix produced by myofibroblasts. Myofibroblasts are the key cells in the pathophysio