Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Bram De Wilde"'
Autor:
Lotte Cornelli, Ruben Van Paemel, Maísa R. Ferro dos Santos, Sofie Roelandt, Leen Willems, Jelle Vandersteene, Edward Baert, Liselot M. Mus, Nadine Van Roy, Bram De Wilde, Katleen De Preter
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Pediatric central nervous system tumors remain challenging to diagnose. Imaging approaches do not provide sufficient detail to discriminate between different tumor types, while the histopathological examination of tumor tissue shows high int
Externí odkaz:
https://doaj.org/article/b09b088a6a4a4632a066f2855b72dcb8
Autor:
Nina U. Gelineau, Astrid van Barneveld, Atia Samim, Lieke Van Zogchel, Nathalie Lak, Michelle L. Tas, Yvette Matser, Annelies M. C. Mavinkurve-Groothuis, Martine van Grotel, Jószef Zsiros, Natasha K. A. van Eijkelenburg, Rutger R. G. Knops, Roelof van Ewijk, Karin P. S. Langenberg, Ronald De Krijger, Laura S. Hiemcke-Jiwa, Ruben Van Paemel, Lotte Cornelli, Katleen De Preter, Bram De Wilde, Ellen Van Der Schoot, Godelieve Tytgat
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Background and aimsSolid tumors account for about 30% of all pediatric cancers. The diagnosis is typically based on histological and molecular analysis of a primary tumor biopsy. Liquid biopsies carry several advantages over conventional tissue biops
Externí odkaz:
https://doaj.org/article/1379e9ffb39d4217ac9e2af4db5290ca
Autor:
Heike Peterziel, Nora Jamaladdin, Dina ElHarouni, Xenia F. Gerloff, Sonja Herter, Petra Fiesel, Yannick Berker, Mirjam Blattner-Johnson, Kathrin Schramm, Barbara C. Jones, David Reuss, Laura Turunen, Aileen Friedenauer, Tim Holland-Letz, Martin Sill, Lena Weiser, Christopher Previti, Gnanaprakash Balasubramanian, Nicolas U. Gerber, Johannes Gojo, Caroline Hutter, Ingrid Øra, Olli Lohi, Antonis Kattamis, Bram de Wilde, Frank Westermann, Stephan Tippelt, Norbert Graf, Michaela Nathrath, Monika Sparber-Sauer, Astrid Sehested, Christof M. Kramm, Uta Dirksen, Olli Kallioniemi, Stefan M. Pfister, Cornelis M. van Tilburg, David T. W. Jones, Jani Saarela, Vilja Pietiäinen, Natalie Jäger, Matthias Schlesner, Annette Kopp-Schneider, Sina Oppermann, Till Milde, Olaf Witt, Ina Oehme
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-17 (2022)
Abstract The international precision oncology program INFORM enrolls relapsed/refractory pediatric cancer patients for comprehensive molecular analysis. We report a two-year pilot study implementing ex vivo drug sensitivity profiling (DSP) using a li
Externí odkaz:
https://doaj.org/article/d21634f309aa434aa0d7808304d8ec37
Autor:
Jill Deleu, Kathleen Schoofs, Anneleen Decock, Kimberly Verniers, Sofie Roelandt, Angie Denolf, Joke Verreth, Bram De Wilde, Tom Van Maerken, Katleen De Preter, Jo Vandesompele
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-14 (2022)
Abstract Background Blood plasma, one of the most studied liquid biopsies, contains various molecules that have biomarker potential for cancer detection, including cell-free DNA (cfDNA) and cell-free RNA (cfRNA). As the vast majority of cell-free nuc
Externí odkaz:
https://doaj.org/article/ef68bffeabae4ba1a11a505e8f590a7c
Autor:
Lucas Moreno, Pierre Teira, James M. Croop, Nicolas U. Gerber, Nicolas André, Isabelle Aerts, Luis Gros Subias, Bram De Wilde, Francisco Bautista, Brian Turpin, Srinivasa Kunduri, Ali Hamidi, Tatiana Lawrence, Keri A. Streby
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
BackgroundThe survival rates for pediatric patients with relapsed and refractory tumors are poor. Successful treatment strategies are currently lacking and there remains an unmet need for novel therapies for these patients. We report here the results
Externí odkaz:
https://doaj.org/article/f28a1250c8b1469e8458cf378d213834
Autor:
Ruben Van Paemel, Andries De Koker, Christa Caggiano, Annelien Morlion, Pieter Mestdagh, Bram De Wilde, Jo Vandesompele, Katleen De Preter
Publikováno v:
Epigenetics, Vol 16, Iss 7, Pp 797-807 (2021)
The methylation pattern of cfDNA, isolated from liquid biopsies, is gaining substantial interest for diagnosis and monitoring of diseases. We have evaluated the impact of type of blood collection tube and time delay between blood draw and plasma prep
Externí odkaz:
https://doaj.org/article/80b0d5ff24a042f0839e131709be5448
Autor:
Bastiaan A. W. van den Beukel, Bram de Wilde, Frank Joosten, Harry van Goor, Wulphert Venderink, Henkjan J. Huisman, Richard P. G. ten Broek
Publikováno v:
Journal of Imaging, Vol 9, Iss 5, p 92 (2023)
Abdominal adhesions present a diagnostic challenge, and classic imaging modalities can miss their presence. Cine-MRI, which records visceral sliding during patient-controlled breathing, has proven useful in detecting and mapping adhesions. However, p
Externí odkaz:
https://doaj.org/article/e1ce864266c5413fb865bea311fd36a0
Autor:
Ruben Van Paemel, Andries De Koker, Charlotte Vandeputte, Lieke van Zogchel, Tim Lammens, Geneviève Laureys, Jo Vandesompele, Gudrun Schleiermacher, Mathieu Chicard, Nadine Van Roy, Ales Vicha, G.A.M. Tytgat, Nico Callewaert, Katleen De Preter, Bram De Wilde
Publikováno v:
Epigenetics, Vol 16, Iss 2, Pp 196-208 (2021)
In the clinical management of paediatric solid tumours, histological examination of tumour tissue obtained by a biopsy remains the gold standard to establish a conclusive pathological diagnosis. The DNA methylation pattern of a tumour is known to cor
Externí odkaz:
https://doaj.org/article/153594e540924d19b722b22372f1d54c
Autor:
Bram de Wilde, Frank Joosten, Wulphert Venderink, Mirjam E. J. Davidse, Juliëtte Geurts, Hanneke Kruijt, Afke Vermeulen, Bibi Martens, Maxime V. P. Schyns, Josephine C. B. M. Huige, Myrte C. de Boer, Bart A. R. Tonino, Herman J. A. Zandvoort, Kirsti Lammert, Helka Parviainen, Aino-Maija Vuorinen, Suvi Syväranta, Ruben R. M. Vogels, Wiesje Prins, Andrea Coppola, Nancy Bossa, Richard P. G. ten Broek, Henkjan Huisman
Publikováno v:
Journal of Imaging, Vol 9, Iss 3, p 55 (2023)
Cine-MRI for adhesion detection is a promising novel modality that can help the large group of patients developing pain after abdominal surgery. Few studies into its diagnostic accuracy are available, and none address observer variability. This retro
Externí odkaz:
https://doaj.org/article/ea11dda886494cbd84f76d94caab230d
Autor:
Anneleen Decock, David Creytens, Steve Lefever, Joni Van der Meulen, Jasper Anckaert, Ariane De Ganck, Jill Deleu, Bram De Wilde, Carolina Fierro, Scott Kuersten, Manuel Luypaert, Isabelle Rottiers, Gary P. Schroth, Sandra Steyaert, Katrien Vanderheyden, Eveline Vanden Eynde, Kimberly Verniers, Joke Verreth, Jo Van Dorpe, Jo Vandesompele
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11007 (2022)
We assess the performance of mRNA capture sequencing to identify fusion transcripts in FFPE tissue of different sarcoma types, followed by RT-qPCR confirmation. To validate our workflow, six positive control tumors with a specific chromosomal rearran
Externí odkaz:
https://doaj.org/article/b547c75db1ae4b15b77ed6e971f9d012