Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Bram, Estes"'
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 617 (2024)
Through machine learning, identifying correlations between amino acid sequences of antibodies and their observed characteristics, we developed an internal viscosity prediction model to empower the rapid engineering of therapeutic antibody candidates.
Externí odkaz:
https://doaj.org/article/219bd2f1841b45528937186404e1c6fe
Autor:
Bram Estes, Athena Sudom, Danyang Gong, Douglas A. Whittington, Vivian Li, Christopher Mohr, Danqing Li, Timothy P. Riley, Stone D.-H. Shi, Jun Zhang, Fernando Garces, Zhulun Wang
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103447- (2021)
Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains fo
Externí odkaz:
https://doaj.org/article/daec344ee874422b8d613ca7fb390ad7
Autor:
Vivian S. W. Li, Fernando Garces, Danqing Li, Stone D.-H. Shi, Jun Zhang, Danyang Gong, Bram Estes, Douglas A. Whittington, Zhulun Wang, Athena Sudom, Christopher Mohr, Timothy P. Riley
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103447-(2021)
iScience
iScience
Summary Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48285a7a04da839a8d6871982ce73830
http://www.sciencedirect.com/science/article/pii/S2589004221014188
http://www.sciencedirect.com/science/article/pii/S2589004221014188
Publikováno v:
Biotechnology Progress. 31:258-267
Mammalian expression systems are used routinely for the production of recombinant proteins as therapeutic molecules as well as research tools. Transient expression has become increasingly popular in recent years due to its rapid timeline and improvem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbcbf4b48124bc8e40e97c7e6b86040
https://doi.org/10.1002/btpr.2021
https://doi.org/10.1002/btpr.2021
Autor:
Richard Zhang, Zhen Xia, Justin Kim, Hsieng Sen Lu, Jennitte Stevens, Mingyue Zhou, Paul Kodama, Jay Tang, Sophia Siu, Chris Spahr, Sihong Deng, Noi Nuanmanee, Bram Estes
Publikováno v:
Protein Science. 22:1739-1753
Recombinant human lecithin-cholesterol acyltransferase Fc fusion (huLCAT-Fc) is a chimeric protein produced by fusing human Fc to the C-terminus of the human enzyme via a linker sequence. The huLCAT-Fc homodimer contains five N-linked glycosylation s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ee29fd84a9456a29f2701f4d003596f
https://doi.org/10.1002/pro.2373
https://doi.org/10.1002/pro.2373
Autor:
Joel Kreps, Molly Dunn, Hur-Song Chang, Ivan Baxter, M. Safiullah Pathan, Alma Sanchez, Henry T. Nguyen, Tong Zhu, Samuel P. Hazen, Bram Estes
Publikováno v:
Functional & Integrative Genomics. 5:104-116
Plants alter their gene expression patterns in response to drought. Sometimes these transcriptional changes are successful adaptations leading to tolerance, while in other instances the plant ultimately fails to adapt to the stress and is labeled as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffdf180669896a73d826adf9117698b
https://doi.org/10.1007/s10142-004-0126-x
https://doi.org/10.1007/s10142-004-0126-x
Autor:
Bram Estes, Tong Zhu, Wenqiong Chen, Jean-Pierre Métraux, Jane Glazebrook, Hur Song Chang, Christiane Nawrath, Fumiaki Katagiri
Publikováno v:
The Plant Journal. 34:217-228
The signal transduction network controlling plant responses to pathogens includes pathways requiring the signal molecules salicylic acid (SA), jasmonic acid (JA), and ethylene (ET). The network topology was explored using global expression phenotypin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cc34dad239a22069dc61f64d7367251
https://doi.org/10.1046/j.1365-313x.2003.01717.x
https://doi.org/10.1046/j.1365-313x.2003.01717.x
Autor:
Bram Estes, Nicholas J. Provart, Sonia Guimil, Wenpei Su, Guangzhou Zou, Wenqiong Chen, Paul Budworth, Tong Zhu, Xun Wang, Hur-Song Chang
Publikováno v:
Plant Biotechnology Journal. 1:59-70
Cereal grains accumulate carbohydrates, storage proteins and fatty acids via different pathways during their development. Many genes that participate in nutrient partitioning during grain filling and that affect starch quality have been identified. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03b17d79b196dcc36e2b604dca26b3d9
https://doi.org/10.1046/j.1467-7652.2003.00006.x
https://doi.org/10.1046/j.1467-7652.2003.00006.x
Autor:
Tong, Zhu, Paul, Budworth, Wenqiong, Chen, Nicholas, Provart, Hur-Song, Chang, Sonia, Guimil, Wenpei, Su, Bram, Estes, Guangzhou, Zou, Xun, Wang
Publikováno v:
Plant biotechnology journal. 1(1)
Cereal grains accumulate carbohydrates, storage proteins and fatty acids via different pathways during their development. Many genes that participate in nutrient partitioning during grain filling and that affect starch quality have been identified. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ca841374d379d0146cad870f8e2a6eb
https://pubmed.ncbi.nlm.nih.gov/17147681
https://pubmed.ncbi.nlm.nih.gov/17147681
Autor:
Wenqiong J, Chen, Sherman H, Chang, Matthew E, Hudson, Wai-King, Kwan, Jingqiu, Li, Bram, Estes, Daniel, Knoll, Liang, Shi, Tong, Zhu
Publikováno v:
Genome Biology
Among five accessions 7,508 probe sets with no detectable genomic sequence variations were identified on the basis of the comparative genomic hybridization to the Arabidopsis GeneChip microarray, and used for accession-specific transcriptome analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b934da81a3dbb807eea0e252774e0b54
https://pubmed.ncbi.nlm.nih.gov/15833119
https://pubmed.ncbi.nlm.nih.gov/15833119