Výsledky vyhledávání - "Brajeswar Paul"

Synthesis, structure, and conformation of anti-tumor agents in the solid and solution states: hydroxyl derivatives of Ftorafur

Autor: James L. Alderfer, Robert M. Wollman, Brajeswar Paul, David M Stokes, Thamarapu Srikrishnan

Publikováno v: Nucleosides, nucleotidesnucleic acids. 21(11-12)

The pyrimidine antimetabolite Ftorafur [FT; 5-fluoro-1-(tetrahydro-2-furyl)uracil] has shown significant antitumor activity in several adenocarcinomas with a spectrum of activity similar to, but less toxic than, 5-fluorouracil (5-FU). It is considere

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4309d85e3ae3d3870a158b5fb5d9f021
https://pubmed.ncbi.nlm.nih.gov/12537027

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Biological properties of fluoroglutamate-containing analogs of folates and methotrexate with altered capacities to form poly (gamma-glutamate) metabolites

Autor: James K. Coward, Kathryn J. Magee, John Galivan, John J. McGuire, William H. Haile, Myung S. Rhee, Wanda E. Bolanowska, Barry P. Hart, Cynthia A. Russell, Brajeswar Paul

Publikováno v: Biochemical pharmacology. 52(8)

Fluoroglutamate-containing analogs of folates and methotrexate (MTX) with altered capacities for poly (gamma-glutamate) metabolism were synthesized to probe the biological roles of polyglutamates. Compared to folic acid, DL-e,t-gamma-fluorofolic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a465ac1142958bc1e7b0b55ab5a5d332
https://pubmed.ncbi.nlm.nih.gov/8937438

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Fluorinated carbohydrates as potential plasma membrane modifiers. Synthesis of 4- and 6-fluoro derivatives of 2-acetamido-2-deoxy-D-hexopyranoses

Autor: Moheswar Sharma, Ralph J. Bernacki, Brajeswar Paul, Walter Korytnyk

Publikováno v: Carbohydrate research. 198(2)

2-Amino-2,4-dideoxy-4-fluoro- and 2-amino-2,4,6-trideoxy-4, 6-difluoro-D-galactose, and 2-amino-2,4-dideoxy-4-fluoro- and 2-amino-4-deoxy-4, 4-difluoro-D-xylo-hexose were synthesized, as potential modifiers of tumor cell-surface glyco-conjugate, from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce1f29b787d96a6b24af6d639495fa6
https://pubmed.ncbi.nlm.nih.gov/2379186

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Synthesis of 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-d-glucopyranosylamine and dimer formation

Autor: Walter Korytnyk, Brajeswar Paul

Publikováno v: Carbohydrate Research. 67:457-468

the synthesis of 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β- d -glucopyranosylamine (2), the key intermediate in glycopeptide synthesis, has been improved. The dimerization of 2 has been studied as a model for its activity in biological systems. The f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56be3718b7709c92df355947463c79f4
https://doi.org/10.1016/s0008-6215(00)84133-6

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S-, N-, and O-glycosyl derivatives of 2-acetamido-2-deoxy-d-glucose with hydrophobic aglycons as potential chemotherapeutic agents and N-acetyl-β-d-glucosaminidase inhibitors

Autor: Brajeswar Paul, Walter Korytnyk

Publikováno v: Carbohydrate Research. 126:27-43

S-, N-, and O-Glycosyl derivatives of 2-acetamido-2-deoxy-D-glucose with hydrophobic aglycons have been obtained as potential, plasma-membrane active agents. 2-Acetamido-3,4,6-tri-O-acetyl-2-deoxy-1-thio-beta-D-glucopyranose (6) was converted into be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb511b12c1bb78fed9fc825681b3899
https://doi.org/10.1016/0008-6215(84)85124-1

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Selective modification of the 2-position of pyridoxol

Autor: M. Alice Becker, Graham R. Underwood, Brajeswar Paul

Publikováno v: Journal of Heterocyclic Chemistry. 13:1229-1232

Pyridoxol, protected by acetylation of the hydroxyl groups, has been converted to its N-oxide which upon reaction with perfluoroacetie anhydride yields a 2-nor-2-hydroxymethylpyridoxol derivative as an intermediate. This compound undergoes acyl migra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9364f3adc074374e982089195e7c8501
https://doi.org/10.1002/jhet.5570130616

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Synthesis and biological activity of some 1-N-substituted 2-acetamido-2-deoxy-β-d-glycopyranosylamine derivatives and related analogs

Autor: Brajeswar Paul, Ralph J. Bernacki, Walter Korytnyk

Publikováno v: Carbohydrate Research. 80:99-115

Several 1-N-substituted derivatives [haloacetyl-, glycyl-, (dimethyl)aminoacetyl-, azidoacetyl-, trifluoroacetyl-, and trifluoromethylsulfonyl-] of 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β- d -glucopyranosylamine (1) were synthesized as potential me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a4406c70a5c68dd85ba13b893a729e
https://doi.org/10.1016/s0008-6215(00)85318-5

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