Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Brajendra K, Tripathi"'
Autor:
Brajendra K. Tripathi, Meghan F. Anderman, Disha Bhargava, Luciarita Boccuzzi, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, Alex G. Papageorge, Fernando J. de Miguel, Katerina Politi, Kylie J. Walters, James H. Doroshow, Douglas R. Lowy
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The tumor suppressor gene DLC1 can be downregulated in cancers through genetic and non-genetic mechanisms. Here, the authors show cytoplasmic EZH2 can directly methylate and destabilize the DLC1 protein, and EZH2 inhibition can increase the DLC1 prot
Externí odkaz:
https://doaj.org/article/7176f11d2bb2458e8f04d65843a147be
Autor:
Shazia Ashraf, Hiroki Kudo, Jia Rao, Atsuo Kikuchi, Eugen Widmeier, Jennifer A. Lawson, Weizhen Tan, Tobias Hermle, Jillian K. Warejko, Shirlee Shril, Merlin Airik, Tilman Jobst-Schwan, Svjetlana Lovric, Daniela A. Braun, Heon Yung Gee, David Schapiro, Amar J. Majmundar, Carolin E. Sadowski, Werner L. Pabst, Ankana Daga, Amelie T. van der Ven, Johanna M. Schmidt, Boon Chuan Low, Anjali Bansal Gupta, Brajendra K. Tripathi, Jenny Wong, Kirk Campbell, Kay Metcalfe, Denny Schanze, Tetsuya Niihori, Hiroshi Kaito, Kandai Nozu, Hiroyasu Tsukaguchi, Ryojiro Tanaka, Kiyoshi Hamahira, Yasuko Kobayashi, Takumi Takizawa, Ryo Funayama, Keiko Nakayama, Yoko Aoki, Naonori Kumagai, Kazumoto Iijima, Henry Fehrenbach, Jameela A. Kari, Sherif El Desoky, Sawsan Jalalah, Radovan Bogdanovic, Nataša Stajić, Hildegard Zappel, Assel Rakhmetova, Sharon-Rose Wassmer, Therese Jungraithmayr, Juergen Strehlau, Aravind Selvin Kumar, Arvind Bagga, Neveen A. Soliman, Shrikant M. Mane, Lewis Kaufman, Douglas R. Lowy, Mohamad A. Jairajpuri, Richard P. Lifton, York Pei, Martin Zenker, Shigeo Kure, Friedhelm Hildebrandt
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nephrotic syndrome is the second most common chronic kidney disease but there are no targeted treatment strategies available. Here the authors identify mutations of six genes codifying for proteins involved in cytoskeleton remodelling and modulation
Externí odkaz:
https://doaj.org/article/5fa7365ce28f4895a98f2773a190db3e
Autor:
Douglas R. Lowy, Marian E. Durkin, Brajendra K. Tripathi, Beatriz Sanchez-Solana, Xiaolan Qian, Dunrui Wang
The Rho-GAP activity of DLC1 mutants and focal adhesions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3025858b296defd6955c8967c3f9d05f
https://doi.org/10.1158/0008-5472.22425522
https://doi.org/10.1158/0008-5472.22425522
Autor:
Douglas R. Lowy, Marian E. Durkin, Brajendra K. Tripathi, Beatriz Sanchez-Solana, Xiaolan Qian, Dunrui Wang
In advanced cancer, the RHOA GTPase is often active together with reduced expression of genes encoding Rho-specific GTPase-accelerating proteins (Rho-GAP), which negatively regulate RHOA and related GTPases. Here we used the The Cancer Genome Atlas d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e469da78c301dad90817d846ef5f1ed
https://doi.org/10.1158/0008-5472.c.6512061.v1
https://doi.org/10.1158/0008-5472.c.6512061.v1
Autor:
Douglas R. Lowy, Marian E. Durkin, Brajendra K. Tripathi, Beatriz Sanchez-Solana, Xiaolan Qian, Dunrui Wang
DLC1 and NF1 mutations in various tumor types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b1fb1fe476b96e1d0917c9055234f6
https://doi.org/10.1158/0008-5472.22425534
https://doi.org/10.1158/0008-5472.22425534
Autor:
Douglas R. Lowy, Marian E. Durkin, Brajendra K. Tripathi, Beatriz Sanchez-Solana, Xiaolan Qian, Dunrui Wang
RT-PCR primers for mutagenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b2b2268d1a6bf7ec4c510f066d13c9
https://doi.org/10.1158/0008-5472.22425516
https://doi.org/10.1158/0008-5472.22425516
Autor:
Douglas R. Lowy, Nicholas C. Popescu, William C. Vass, Xu-Yu Yang, Lyra Olson, Brajendra K. Tripathi, Dunrui Wang, Marian E. Durkin, Xiaolan Qian
PDF file - 304K, Suppl. Table 1: Validated siRNAs used in the current studies Suppl. Fig. 1 Stress fiber formation in MEFs with or without v-Ras expression. Suppl. Fig. 2 The spontaneous transformation is reproducible using another Adeno-Cre treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcde8a1fba00e16c4831ea7f45eb4d81
https://doi.org/10.1158/0008-5472.22394400
https://doi.org/10.1158/0008-5472.22394400
Autor:
Douglas R. Lowy, Nicholas C. Popescu, William C. Vass, Xu-Yu Yang, Lyra Olson, Brajendra K. Tripathi, Dunrui Wang, Marian E. Durkin, Xiaolan Qian
The tumor suppressor gene deleted in liver cancer-1 (DLC1), which encodes a protein with strong RhoGAP (GTPase activating protein) activity and weak Cdc42GAP activity, is inactivated in various human malignancies. Following Dlc1 inactivation, mouse e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d160bdb8d0db77be661194b8ded83740
https://doi.org/10.1158/0008-5472.c.6504021.v1
https://doi.org/10.1158/0008-5472.c.6504021.v1
Autor:
Marian E. Durkin, Dunrui Wang, Douglas R. Lowy, Brajendra K. Tripathi, Xiaolan Qian, Beatriz Sánchez-Solana
Publikováno v:
Cancer Research. 80:3568-3579
In advanced cancer, the RHOA GTPase is often active together with reduced expression of genes encoding Rho-specific GTPase-accelerating proteins (Rho-GAP), which negatively regulate RHOA and related GTPases. Here we used the The Cancer Genome Atlas d
Autor:
Katerina Politi, Disha Bhargava, Brajendra K. Tripathi, Meghan F. Anderman, Douglas R. Lowy, Alex G. Papageorge, Luciarita Boccuzzi, Xiaolan Qian, Dunrui Wang, Marian E. Durkin, James H. Doroshow, Fernando J. de Miguel, Kylie J. Walters
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
mRNA expression of the DLC1 tumor suppressor gene is downregulated in many lung cancers and their derived cell lines, with DLC1 protein levels being low or absent. Although the role of increased EZH2 methyltransferase in cancer is usually attributed