L858R/L718Q and L858R/L792H Mutations of EGFR Inducing Resistance Against Osimertinib by Forming Additional Hydrogen Bonds.

Autor: Imam IA; Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky, USA., Al Adawi S; Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky, USA., Liu X; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, USA.; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA., Ellingson S; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.; College of Medicine, Division of Biomedical Informatics University of Kentucky, Lexington, Kentucky, USA., Brainson CF; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, USA.; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA., Moseley HNB; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA., Zinner R; Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA., Zhang S; College of Medicine, Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky, USA., Shao Q; Department of Chemical and Materials Engineering, University of Kentucky, Lexington, Kentucky, USA.

Publikováno v: Proteins [Proteins] 2024 Nov 04. Date of Electronic Publication: 2024 Nov 04.

EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas.

Autor: DuCote TJ; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Song X; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Naughton KJ; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Chen F; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Plaugher DR; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Childress AR; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Gellert AR; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Skaggs EM; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Qu X; Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia., Liu J; Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia.; Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia., Liu J; Department of Cancer Biostatistics, University of Kentucky, Lexington, Kentucky., Li F; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York University, New York, New York., Wong KK; Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York University, New York, New York., Brainson CF; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky.; Markey Cancer Center, University of Kentucky, Lexington, Kentucky.

Publikováno v: Cancer research communications [Cancer Res Commun] 2024 Feb 13; Vol. 4 (2), pp. 388-403.

Isolation, Culture, and Phenotypic Analysis of Murine Lung Organoids.

Autor: Evans K; Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Dabrowska C; Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Ng ME; Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Brainson CF; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, USA.; Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Lee JH; Wellcome - MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. jhl62@cam.ac.uk.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. jhl62@cam.ac.uk.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2805, pp. 3-18.

Using Artificial Intelligence to Identify Tumor Microenvironment Heterogeneity in Non-Small Cell Lung Cancers.

Autor: DuCote TJ; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Naughton KJ; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Skaggs EM; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Bocklage TJ; Markey Cancer Center, University of Kentucky, Lexington, Kentucky; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky., Allison DB; Markey Cancer Center, University of Kentucky, Lexington, Kentucky; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, Kentucky., Brainson CF; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky; Markey Cancer Center, University of Kentucky, Lexington, Kentucky. Electronic address: cfbrainson@uky.edu.

Publikováno v: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2023 Aug; Vol. 103 (8), pp. 100176. Date of Electronic Publication: 2023 May 12.

Crizotinib induces Par-4 secretion from normal cells and GRP78 expression on the cancer cell surface for selective tumor growth inhibition.

Autor: Burikhanov R; Department of Radiation Medicine, College of Medicine, University of Kentucky Lexington, Kentucky, USA., Ganguly S; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky Lexington, Kentucky, USA., Ellingson S; Department of Internal Medicine, College of Medicine, University of Kentucky Lexington, Kentucky, USA., Sviripa VM; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Lexington, Kentucky, USA., Araujo N; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky Lexington, Kentucky, USA., Li S; Department of Medicine, Division of Oncology, Washington University St. Louis, Missouri, USA., Venkatraman P; Tata Memorial Centre-Advanced Centre for Treatment Research and Education in Cancer Navi Mumbai, Maharashtra, India., Rao M; Department of Pharmacy Practice, Center for Translational Research, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education Manipal, Karnataka, India., Choughule A; Tata Memorial Centre-Advanced Centre for Treatment Research and Education in Cancer Navi Mumbai, Maharashtra, India., Brainson CF; Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky Lexington, Kentucky, USA.; Markey Cancer Center, University of Kentucky Lexington, Kentucky, USA., Zhan CG; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Lexington, Kentucky, USA., Spielmann HP; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky Lexington, Kentucky, USA., Watt DS; Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky Lexington, Kentucky, USA., Govindan R; Department of Medicine, Division of Oncology, Washington University St. Louis, Missouri, USA., Rangnekar VM; Department of Radiation Medicine, College of Medicine, University of Kentucky Lexington, Kentucky, USA.; Markey Cancer Center, University of Kentucky Lexington, Kentucky, USA.

Publikováno v: American journal of cancer research [Am J Cancer Res] 2023 Mar 15; Vol. 13 (3), pp. 976-991. Date of Electronic Publication: 2023 Mar 15 (Print Publication: 2023).