Alterations of Neuronal Lysosomes in Alzheimer's Disease and in APPxPS1-KI Mice.

Autor: Androuin, Alexandre, Thierry, Manon, Boluda, Susana, Baskaran, Asha, Langui, Dominique, Duyckaerts, Charles, Potier, Marie-Claude, El Hachimi, Khalid Hamid, Delatour, Benoît, Marty, Serge, Brainbank NeuroCEB Neuropathology Network

Publikováno v: Journal of Alzheimer's Disease; 2022, Vol. 87 Issue 1, p273-284, 12p

Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy.

Autor: Hopfner F; Department of Neurology Hannover Medical School, Hannover, Germany., Tietz AK; Department of Neurology, Kiel University, Kiel, Germany., Ruf VC; Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität, Munich, Germany., Ross OA; Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.; Department of Clinical Genomics, Mayo Clinic, Jacksonville, Florida, USA., Koga S; Department of Neuroscience (Neuropathology), Mayo Clinic, Jacksonville, Florida, USA., Dickson D; Department of Neuroscience (Neuropathology), Mayo Clinic, Jacksonville, Florida, USA., Aguzzi A; Institute of Neuropathology, University Hospital Zürich, Zürich, Switzerland., Attems J; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Beach T; Banner Sun Health Research Institute, Sun City, Arizona, USA., Beller A; Department of Pathology, University of Washington, Seattle, Washington, USA., Cheshire WP; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., van Deerlin V; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Desplats P; Department of Neurosciences, School of Medicine University of California San Diego, La Jolla, California, USA.; Department of Pathology, School of Medicine University of California San Diego, La Jolla, California, USA., Deuschl G; Department of Neurology, Kiel University, Kiel, Germany., Duyckaerts C; Institut du Cerveau, UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, Inserm U1127 DMU Neurosciences, Paris, France.; Brainbank NeuroCEB Neuropathology Network: Plateforme de Ressources Biologiques, Hôpital de La Pitié-Salpêtrière, Bâtiment Roger Baillet, Paris Cedex, France., Ellinghaus D; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel & University Hospital Schleswig-Holstein, Kiel, Germany., Evsyukov V; Department of Neurology Hannover Medical School, Hannover, Germany., Flanagan ME; Mesulam Center for Cognitive Neurology and Alzheimer's Disease Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Pathology, Northwestern University, Chicago, Illinois, USA., Franke A; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel & University Hospital Schleswig-Holstein, Kiel, Germany., Frosch MP; Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.; Harvard Medical School, Boston, Massachusetts, USA.; Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA., Gearing M; Departments of Pathology and Laboratory Medicine and Neurology, Emory University School of Medicine, Atlanta, Georgia, USA., Gelpi E; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.; Medical University of Vienna, Austrian Reference Center for Human Prion Diseases (OERPE), Vienna, Austria., van Gerpen JA; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Ghetti B; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA., Glass JD; Department of Neurology, Emory University, Atlanta, Georgia, USA., Grinberg LT; Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, California, USA.; Global Health Institute, University of California, San Francisco, California, USA.; Department of Pathology, University of California, San Francisco, California, USA.; Department of Pathology, University of Sao Paulo Medical School, Sao Paulo, Brazil., Halliday G; The University of Sydney, School of Medical Sciences, and Brain & Mind Centre, Sydney, New South Wales, Australia., Helbig I; Department of Biomedical Informatics, Columbia University Irving Medical Center, New York, New York, USA.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; The Epilepsy NeuroGenetics Initiative (ENGIN), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Höllerhage M; Department of Neurology Hannover Medical School, Hannover, Germany., Huitinga I; Department of Neuroimmunology, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.; Brain Plasticity Group, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands., Irwin DJ; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Keene DC; Department of Pathology, University of Washington, Seattle, Washington, USA., Kovacs GG; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria.; Department of Laboratory Medicine and Pathobiology and Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada.; Laboratory Medicine Program and Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada., Lee EB; Department of Pathology and Laboratory Medicine, Translational Neuropathology Research Laboratory Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Levin J; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany., Martí MJ; Parkinson's Disease and Movement Disorders Unit, Department of Neurology, Hospital Clinic of Barcelona, Barcelona, Spain.; Institut de Neurociències, Maeztu Center, University of Barcelona, Barcelona, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain., Mackenzie I; Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pathology, Vancouver General Hospital, Vancouver, British Columbia, Canada., McKeith I; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Mclean C; Department of Anatomical Pathology, Alfred Health, Melbourne, Victoria, Australia., Mollenhauer B; Paracelsus-Elena-Klinik, Kassel, Germany.; Department of Neurology, University Medical Center Goettingen, Gottingen, Germany., Neumann M; Molecular Neuropathology of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Tübingen, Germany.; Department of Neuropathology, University Hospital of Tübingen, Tübingen, Germany., Newell KL; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA., Pantelyat A; Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA., Pendziwiat M; Department of Neuropediatrics, Children's Hospital, University Medical Center Schleswig-Holstein, University of Kiel, Kiel, Germany.; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Molina Porcel L; Neurology Department, Hospital Clinic, IDIBAPS, Barcelona, Spain., Rabano A; Neuropathology Department, CIEN Foundation, Alzheimer's Centre Queen Sofía Foundation, Madrid, Spain., Matěj R; Department of Pathology, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady, Prague, Czech Republic.; Department of Pathology and Molecular Medicine, 3rd Faculty of Medicine, Charles University, Thomayer University Hospital, Prague, Czech Republic., Rajput A; Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Rajput A; Saskatchewan Movement Disorders Program, Saskatchewan Health Authority/University of Saskatchewan, Saskatoon, Saskatchewan, Canada., Reimann R; Institute of Neuropathology, University Hospital Zürich, Zürich, Switzerland., Scott WK; John P. Hussman Institute for Human Genomics and Dr. John T. Macdonald Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, Florida, USA., Seeley W; Memory and Aging Center, Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, California, USA.; Global Health Institute, University of California, San Francisco, California, USA.; Department of Pathology, University of California, San Francisco, California, USA., Selvackadunco S; Basic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Simuni T; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Stadelmann C; Institute for Neuropathology, University Medical Centre Göttingen, Göttingen, Germany., Svenningsson P; Section of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden., Thomas A; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Trenkwalder C; Paracelsus-Elena-Klinik, Kassel, Germany.; Department of Neurosurgery, University Medical Center Goettingen, Goettingen, Germany., Troakes C; Basic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom., Trojanowski JQ; Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine, Philadelphia, Pennsylvania, USA., Uitti RJ; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., White CL; Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA., Wszolek ZK; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA., Xie T; Department of Neurology, University of Chicago Medicine, Chicago, Illinois, USA., Ximelis T; Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain., Yebenes J; Neurological Tissue Bank, Biobanc-Hospital Clínic-IDIBAPS, Barcelona, Spain.; Servicio de Neurología, Hospital Ramón y Cajal de Madrid, Madrid, Spain., Müller U; Institute of Human Genetics, JLU-Gießen, Giessen, Germany., Schellenberg GD; Department of Pathology and Laboratory Medicine, Penn Neurodegeneration Genomics Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Herms J; Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität, Munich, Germany.; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Kuhlenbäumer G; Department of Neurology, Kiel University, Kiel, Germany., Höglinger G; Department of Neurology Hannover Medical School, Hannover, Germany.; DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.; Zentrum für Systemische Neurowissenschaften, Hannover, Germany.

Publikováno v: Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2022 Oct; Vol. 37 (10), pp. 2110-2121. Date of Electronic Publication: 2022 Aug 23.

Transmission of amyloid-beta and tau pathologies is associated with cognitive impairments in a primate.

Autor: Lam S; Laboratoire des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.; Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France., Petit F; Laboratoire des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.; Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France., Hérard AS; Laboratoire des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.; Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France., Boluda S; Institut du Cerveau, UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, Inserm U1127 DMU Neurosciences, Paris, France.; Brainbank NeuroCEB Neuropathology Network : Plateforme de Ressources Biologiques, Hôpital de La Pitié-Salpêtrière, Bâtiment Roger Baillet, 47-83 boulevard de l'Hôpital, 75651, Paris Cedex 13, France., Eddarkaoui S; Université de Lille, CHU-Lille, LabEx DISTALZ, Alzheimer & Tauopathies, Rue Polonovski, 59045, Lille, France., Guillermier M; Laboratoire des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.; Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France., Buée L; Université de Lille, CHU-Lille, LabEx DISTALZ, Alzheimer & Tauopathies, Rue Polonovski, 59045, Lille, France., Duyckaerts C; Institut du Cerveau, UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, Inserm U1127 DMU Neurosciences, Paris, France.; Brainbank NeuroCEB Neuropathology Network : Plateforme de Ressources Biologiques, Hôpital de La Pitié-Salpêtrière, Bâtiment Roger Baillet, 47-83 boulevard de l'Hôpital, 75651, Paris Cedex 13, France., Haïk S; Institut du Cerveau, UMR 7225, Sorbonne Université, Paris Brain Institute-ICM, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, Inserm U1127 DMU Neurosciences, Paris, France.; Brainbank NeuroCEB Neuropathology Network : Plateforme de Ressources Biologiques, Hôpital de La Pitié-Salpêtrière, Bâtiment Roger Baillet, 47-83 boulevard de l'Hôpital, 75651, Paris Cedex 13, France., Picq JL; Laboratoire des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.; Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.; Laboratory of Cognitive Functioning and Dysfunctioning (DysCo), University of Paris 8, 93526 cedex, Saint-Denis, France., Dhenain M; Laboratoire des Maladies Neurodégénératives, Université Paris-Saclay, CEA, CNRS, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France. marc.dhenain@cea.fr.; Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France. marc.dhenain@cea.fr.

Publikováno v: Acta neuropathologica communications [Acta Neuropathol Commun] 2021 Oct 12; Vol. 9 (1), pp. 165. Date of Electronic Publication: 2021 Oct 12.