Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Brain Neoplasms/metabolism"'
Autor:
Seliger, Corinna, Rauer, Lisa, Wüster, Anne-Louise, Moeckel, Sylvia, Leidgens, Verena, Jachnik, Birgit, Ammer, Laura-Marie, Heckscher, Simon, Dettmer, Katja, Riemenschneider, Markus J., Oefner, Peter J., Proescholdt, Martin A., Vollmann-Zwerenz, Arabel, Hau, Peter
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 4; Pages: 3199
Glioblastomas are highly malignant brain tumors that derive from brain-tumor-initiating cells (BTICs) and can be subdivided into several molecular subtypes. Metformin is an antidiabetic drug currently under investigation as a potential antineoplastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7108888aa61a10ac859ffd86185877f
https://epub.uni-regensburg.de/54264/
https://epub.uni-regensburg.de/54264/
Publikováno v:
International Journal of Molecular Sciences
Volume 24
Issue 4
Pages: 3075
Volume 24
Issue 4
Pages: 3075
Glioblastoma multiforme (GBM), a grade IV glioma, is a challenging disease for patients and clinicians, with an extremely poor prognosis. These tumours manifest a high molecular heterogeneity, with limited therapeutic options for patients. Since GBM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c5d60a5669951529f49da29bd929f5
http://orbilu.uni.lu/handle/10993/54560
http://orbilu.uni.lu/handle/10993/54560
Autor:
Arnaud Comment, Olga Gusyatiner, Bernard Lanz, Jocelyne Bloch, Irene Vassallo, Marie-France Hamou, Mor Mishkovsky, Rolf Gruetter, Monika E. Hegi, Cristina Cudalbu
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Scientific reports, vol. 11, no. 1, pp. 5771
Scientific reports, vol. 11, no. 1, pp. 5771
Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using sta
Autor:
Elham, Kashani, Désirée, Schnidrig, Ali, Hashemi Gheinani, Martina Selina, Ninck, Philipp, Zens, Theoni, Maragkou, Ulrich, Baumgartner, Philippe, Schucht, Gunnar, Rätsch, Mark A, Rubin, Sabina, Berezowska, Charlotte K Y, Ng, Erik, Vassella
Publikováno v:
Neuro-oncology, vol. 25, no. 4, pp. 662-673
Background Adult-type diffuse gliomas, CNS WHO grade 4 are the most aggressive primary brain tumors and represent a particular challenge for therapeutic intervention. Methods In a single-center retrospective study of matched pairs of initial and post
Autor:
Jessy V. van Asperen, Miriam E. van Strien, Emma J. van Bodegraven, Coen B J van Deursen, Oscar M. J. A. Stassen, Pierre A. Robe, Elly M. Hol, Jacqueline A. Sluijs
Publikováno v:
The FASEB Journal, 33(11), 12941-12959. FASEB
Gliomas are the most common primary brain tumors. Their highly invasive character and the heterogeneity of active oncogenic pathways within single tumors complicate the development of curative therapies and cause poor patient prognosis. Glioma cells
Autor:
Jean-Philippe Brouland, Cristina Cudalbu, Lijing Xin, Andreas F. Hottinger, Roy Thomas Daniel, Monika E. Hegi, Pierre Bady, Marta Lai, Olga Gusyatiner, Mario Lepore, Marie-France Hamou
Publikováno v:
Acta neuropathologica communications, vol. 9, no. 1, pp. 133
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Acta Neuropathologica Communications
BioRxiv
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Acta Neuropathologica Communications
BioRxiv
The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7278226f5c798527e12857fb894c162
https://serval.unil.ch/notice/serval:BIB_CB8B36AE633E
https://serval.unil.ch/notice/serval:BIB_CB8B36AE633E
Autor:
Tomislav Sajko, Željka Vukelić, Ruđer Novak, Dragana Fabris, Mia Jurilj, Slavica Potočki, Ivana Karmelić, Hasan Muharemović
Publikováno v:
International Journal of Molecular Sciences
International journal of molecular sciences
International Journal of Molecular Sciences, Vol 22, Iss 8844, p 8844 (2021)
Volume 22
Issue 16
International journal of molecular sciences
International Journal of Molecular Sciences, Vol 22, Iss 8844, p 8844 (2021)
Volume 22
Issue 16
Gangliosides serve as antitumor therapy targets and aberrations in their composition strongly correlate with tumor growth and invasiveness. Anaplastic ganglioglioma is a rare, poorly characterized, malignant neuronal–glial tumor type. We present th
Autor:
Wellens, Lianne M, Deken, Marion M, Sier, Cornelis F M, Johnson, Hannah R, de la Jara Ortiz, Fàtima, Bhairosingh, Shadhvi S, Houvast, Ruben D, Kholosy, Waleed M, Baart, Victor M, Pieters, Annique M M J, de Krijger, Ronald R, Molenaar, Jan J, Wehrens, Ellen J, Dekkers, Johanna F, Wijnen, Marc H W A, Vahrmeijer, Alexander L, Rios, Anne C, UU BETA RESEARCH
Publikováno v:
Scientific Reports, 10(1). NATURE RESEARCH
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, 10(1). NLM (Medline)
Scientific Reports
Neuroblastoma resection represents a major challenge in pediatric surgery, because of the high risk of complications. Fluorescence-guided surgery (FGS) could lower this risk by facilitating discrimination of tumor from normal tissue and is gaining mo
Publikováno v:
Clinicaltranslational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 23(6)
Purpose: E-cadherin is a calcium-dependent glycoprotein whose main role is cell-cell adhesion. Its transcriptional repressor TWIST1 is a basic helix-loop-helix (bHLH) protein that participates in gastrulation and formation of mesodermal tissues durin
Autor:
Philip Kresl, Adelheid Wöhrer, Christine Marosi, Barbara Kiesel, Dorothee Wilhelm, Sebastian Kurscheid, Anna S. Berghoff, Georg Widhalm, Monika E. Hegi, Orsolya Rajky, Matthias Preusser
Publikováno v:
Neuro-oncology, vol. 19, no. 11, pp. 1460-1468
Tumor infiltrating lymphocytes (TILs) and programmed death ligand 1 (PD-L1) are targets of immune checkpoint inhibitors. Forty-three World Health Organization (WHO) grade II/III gliomas (39 IDH-mutant [mut], 4 IDH-wildtype [wt]) and 14 IDH-mut gliobl