Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Brahmam, Pujala"'
Autor:
Zahid Rafiq Bhat, Manvendra Kumar, Nisha Sharma, Umesh Prasad Yadav, Tashvinder Singh, Gaurav Joshi, Brahmam Pujala, Mohd Raja, Joydeep Chatterjee, Kulbhushan Tikoo, Sandeep Singh, Raj Kumar
Publikováno v:
Molecules, Vol 27, Iss 17, p 5540 (2022)
Tyrosine kinase inhibitors are validated therapeutic agents against EGFR-mutated non-small cell lung cancer (NSCLC). However, the associated critical side effects of these agents are inevitable, demanding more specific and efficient targeting agents.
Externí odkaz:
https://doaj.org/article/ff6a738439274ecfb17650390e6c5f81
Autor:
Brahmam Pujala, Sreekanth A. Ramachandran, Mukesh Sonawane, Maruti M. Kamble, Dayanand Panpatil, Swati Adhikari, Sanjeev Soni, Venkata Subbareddy, Bharat U. Shinde, Anjan K. Nayak, Chandni Bansal, Ashu Gupta, Kakoli Mukherjee, Anil K. Agarwal, Javier Guerrero, Francisco J. Herrera, Sebastian Bernales, Mausumee Guha, Sarvajit Chakravarty, Son M. Pham, Roopa Rai
Publikováno v:
Bioorganicmedicinal chemistry letters. 75
Compound 1 is a potent TGF-β receptor type-1 (TGFβR1 or ALK5) inhibitor but is metabolically unstable. A solvent-exposed part of this molecule was used to analogue and modulate cell activity, liver microsome stability and mouse pharmacokinetics. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284f050e012e992686c32f90ce8a56e0
https://pubmed.ncbi.nlm.nih.gov/36089110
https://pubmed.ncbi.nlm.nih.gov/36089110
Autor:
Sreekanth A. Ramachandran, Anil K. Agarwal, Maruti M. Kamble, Brahmam Pujala, Ratnesh Sharma, Manvendra Singh, Bharat U. Shinde, Dayanand Panpatil, Ashu Gupta, Kakoli Mukherjee, Srijan Haldar, Chandni Bansal, Roopa Rai, Sarvajit Chakravarty, Son M. Pham
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56c629bf57fd5dc45c4ca20b0b967c02
https://doi.org/10.2139/ssrn.4159512
https://doi.org/10.2139/ssrn.4159512
Autor:
Brahmam Pujala, Balaji Dashrath Sathe, Ashu Gupta, Abhinandan Danodia, Sanjeev Soni, Vivek Kumar, Uzma Saeed, Sarvajit Chakravarty
Publikováno v:
Cancer Research. 82:5465-5465
Nuclear receptors, liver X receptor-α (LXRα) and liver X receptor-β (LXRβ), are considered master regulators of lipid homeostasis and play pivotal roles in several physiological and pathological processes ranging from energy supply, cardiovascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b4073802f0d151c12603ced3f745b3
https://doi.org/10.1158/1538-7445.am2022-5465
https://doi.org/10.1158/1538-7445.am2022-5465
Autor:
Luz Delgado, Roopa Rai, Shailender Chauhan, Patricio Avila, Dhananjay I. Patel, Glenda Fuentealba, Camila Flores, Kevin P. Quinn, T. V. R. Upendra, Vijay Kumar Sharma, Sarvajit Chakravarty, Anjan Kumar Nayak, Emma McCullagh, Gonzalo Ureta, Ramona Almirez, Brahmam Pujala, Sebastian Bernales, Jennifer Alfaro, David T. Hung, Son Minh Pham, Diana Gaete, Sebastian Belmar, Felipe Pérez de Arce, Stacy Kanno, Claudia Acuña, Anup Barde
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:312-321
Although new targeted therapies, such as ibrutinib and idelalisib, have made a large impact on non-Hodgkin's lymphoma (NHL) patients, the disease is often fatal because patients are initially resistant to these targeted therapies, or because they eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a88d9ba848c5c5372e62f468a36b17ce
https://doi.org/10.1124/jpet.116.238022
https://doi.org/10.1124/jpet.116.238022
Autor:
Michael J. Green, Roopa Rai, Kevin P. Quinn, Ashu Gupta, Jennifer Alfaro, Dhananjay I. Patel, David T. Hung, Stacy Kanno, Nitin Atmaram Randive, Emma McCullagh, Monali Banerjee, Anamika Thakur, Sarvajit Chakravarty, Anjan Kumar Nayak, Anil Agarwal, Ramona Almirez, Sweta Khare, Brahmam Pujala, Rambabu Guguloth, Sebastian Bernales, Sandip Middya, Mohd. Raja, Son Minh Pham, Bharat Uttam Shinde, Felipe Pérez de Arce, Arjun Surya, Patricio Avila
Publikováno v:
ACS Medicinal Chemistry Letters. 7:1161-1166
The aberrant activation of B-cells has been implicated in several types of cancers and hematological disorders. BTK and PI3Kδ are kinases responsible for B-cell signal transduction, and inhibitors of these enzymes have demonstrated clinical benefit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36968f9bd3299d938b2fbcd47dfe5c0
https://doi.org/10.1021/acsmedchemlett.6b00356
https://doi.org/10.1021/acsmedchemlett.6b00356
Publikováno v:
Journal of Analytical Chemistry. 69:1206-1213
The methods for the separation of racemic compounds [(RS)-1-bromo-3-chloro-2-propanol, (RS)-1-bromo-3-chloropropan-2-yl acetate] into the corresponding enantiomers were tried to develop in high performance liquid chromatography in a single injection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5dca167f15bd9499800db898d5d6fef4
https://doi.org/10.1134/s1061934815010098
https://doi.org/10.1134/s1061934815010098
Publikováno v:
Synthesis. 46:479-488
A new chemical and the first chemoenzymatic synthesis of β-adrenergic receptor blocking agent bunitrolol is reported in racemic (RS) and enantioenriched forms (R and S). The intermediates (R)- and (S)-1-chloro-3-(2-cyanophenoxy)propan-2-ol intermedi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f2aa7625379157c65a98aa637892690
https://doi.org/10.1055/s-0033-1340465
https://doi.org/10.1055/s-0033-1340465
Autor:
Asit K. Chakraborti, Thete Karuna Narayan, Uttam Chand Banerjee, Brahmam Pujala, Linga Banoth
Publikováno v:
Tetrahedron: Asymmetry. 23:1564-1570
The present study deals with the efficient chemo-enzymatic synthesis of enantiopure (R)-1-chloro-3-(piperidin-1-yl) propan-2-ol 3, as an intermediate for (R)-arimoclomol. This intermediate was synthesized from racemic alcohol (RS)-3 using lipases wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23c9278fa3f8cfb8696954506baa7efb
https://doi.org/10.1016/j.tetasy.2012.10.008
https://doi.org/10.1016/j.tetasy.2012.10.008
Autor:
Jennifer, Alfaro, Felipe, Pérez de Arce, Sebastián, Belmar, Glenda, Fuentealba, Patricio, Avila, Gonzalo, Ureta, Camila, Flores, Claudia, Acuña, Luz, Delgado, Diana, Gaete, Brahmam, Pujala, Anup, Barde, Anjan K, Nayak, T V R, Upendra, Dhananjay, Patel, Shailender, Chauhan, Vijay K, Sharma, Stacy, Kanno, Ramona G, Almirez, David T, Hung, Sarvajit, Chakravarty, Roopa, Rai, Sebastián, Bernales, Kevin P, Quinn, Son M, Pham, Emma, McCullagh
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 361(2)
Although new targeted therapies, such as ibrutinib and idelalisib, have made a large impact on non-Hodgkin's lymphoma (NHL) patients, the disease is often fatal because patients are initially resistant to these targeted therapies, or because they eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f7e8d9a06c49ef42e973fc8a84ac5ee2
https://pubmed.ncbi.nlm.nih.gov/28298527
https://pubmed.ncbi.nlm.nih.gov/28298527