Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Brahm H. Segal"'
Autor:
Spencer R. Rosario, Mark D. Long, Shanmuga Chilakapati, Eduardo Cortes Gomez, Sebastiano Battaglia, Prashant K. Singh, Jianmin Wang, Katy Wang, Kristopher Attwood, Suzanne M. Hess, AJ Robert McGray, Kunle Odunsi, Brahm H. Segal, Gyorgy Paragh, Song Liu, Jennifer A. Wargo, Emese Zsiros
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Recurrent ovarian cancer patients, especially those resistant to platinum, lack effective curative treatments. To address this, we conducted a phase 2 clinical trial (NCT02853318) combining pembrolizumab with bevacizumab, to increase T cell
Externí odkaz:
https://doaj.org/article/70dcee0bb9064927b3d9ece85a9d7ca9
Autor:
Melissa Van Norden, Zackary Falls, Sapan Mandloi, Brahm H. Segal, Bora E. Baysal, Ram Samudrala, Peter L. Elkin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Intra-organism biodiversity is thought to arise from epigenetic modification of constituent genes and post-translational modifications of translated proteins. Here, we show that post-transcriptional modifications, like RNA editing, may also
Externí odkaz:
https://doaj.org/article/b55971b1c57b43fbb50a94f454ea9ef3
Autor:
Paolo A. Ascierto, Antonio Avallone, Carlo Bifulco, Sergio Bracarda, Joshua D. Brody, Leisha A. Emens, Robert L. Ferris, Silvia C. Formenti, Omid Hamid, Douglas B. Johnson, Tomas Kirchhoff, Christopher A. Klebanoff, Gregory B. Lesinski, Anne Monette, Bart Neyns, Kunle Odunsi, Chrystal M. Paulos, Daniel J. Powell, Katayoun Rezvani, Brahm H. Segal, Nathan Singh, Ryan J. Sullivan, Bernard A. Fox, Igor Puzanov
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-21 (2023)
Abstract The discovery and development of novel treatments that harness the patient’s immune system and prevent immune escape has dramatically improved outcomes for patients across cancer types. However, not all patients respond to immunotherapy, a
Externí odkaz:
https://doaj.org/article/627c0bedba0a40d4b9dd41c55b9dde62
Autor:
Neha Mehta, Jennifer M. Harrington, Meghan A. Wallace, Jillianna M. Wasiura, Carey-Ann D. Burnham, Katherine M. Mullin, Brahm H. Segal, Nikolaos G. Almyroudis
Publikováno v:
Antimicrobial Stewardship & Healthcare Epidemiology, Vol 3 (2023)
Ribotyping was performed on Clostridioides difficile isolates from patients with malignancies. Thirty-one (27.9%) isolates from 111 episodes of colitis were recovered representing 14 ribotypes with 25 (80.6%) belonging to 6 ribotypes (014/020, 1/VPI/
Externí odkaz:
https://doaj.org/article/54e6dba26bad419ea689dd59f7f8039b
Autor:
Takayoshi Yamauchi, Toshifumi Hoki, Takaaki Oba, Vaibhav Jain, Hongbin Chen, Kristopher Attwood, Sebastiano Battaglia, Saby George, Gurkamal Chatta, Igor Puzanov, Carl Morrison, Kunle Odunsi, Brahm H. Segal, Grace K. Dy, Marc S. Ernstoff, Fumito Ito
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
There is an urgent need to discover blood-based biomarkers to predict response to immune checkpoint inhibitors (ICI). Here the authors show that effective ICI therapy correlates with increased frequency of circulating CX3CR1+CD8+ T cells in preclinic
Externí odkaz:
https://doaj.org/article/5ad9763c2d134ba4b389bb215a94772a
Autor:
Emad Y. Alqassim, Shraddha Sharma, A. N. M. Nazmul H. Khan, Tiffany R. Emmons, Eduardo Cortes Gomez, Abdulrahman Alahmari, Kelly L. Singel, Jaron Mark, Bruce A. Davidson, A. J. Robert McGray, Qian Liu, Brian D. Lichty, Kirsten B. Moysich, Jianmin Wang, Kunle Odunsi, Brahm H. Segal, Bora E. Baysal
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Alqassim et al find that RNA editing, known to be induced by IFN-1 in macrophages by the enzyme APOBEC3A, is required for the transcriptional, pro-inflammatory and metabolic responses that drive M1 macrophage polarization. APOBEC3A-mediated editing i
Externí odkaz:
https://doaj.org/article/8289df36f80e4288872e7c05d2e770f3
Autor:
Brahm H. Segal, Zvi Fridlender
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/bd826af36e894f03af74a72c97ae21ab
Autor:
Shraddha Sharma, Jianmin Wang, Emad Alqassim, Scott Portwood, Eduardo Cortes Gomez, Orla Maguire, Per H. Basse, Eunice S. Wang, Brahm H. Segal, Bora E. Baysal
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-17 (2019)
Abstract Background Protein recoding by RNA editing is required for normal health and evolutionary adaptation. However, de novo induction of RNA editing in response to environmental factors is an uncommon phenomenon. While APOBEC3A edits many mRNAs i
Externí odkaz:
https://doaj.org/article/4cb51bbdf793402da1a28e36fd3f9e70
Autor:
Eihab Abdelfatah, Mark D. Long, Ryutaro Kajihara, Takaaki Oba, Takayoshi Yamauchi, Hongbin Chen, Joy Sarkar, Kristopher Attwood, Junko Matsuzaki, Brahm H. Segal, Grace K. Dy, Fumito Ito
Publikováno v:
Cancer Research Communications. 3:510-520
Lack of reliable predictive biomarkers is a major limitation of combination therapy with chemotherapy and anti–programmed cell death protein 1/programmed death-ligand 1 (anti-PD-1/PD-L1) therapy (chemo-immunotherapy). We previously observed that th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6605bbdf9c3c91c0a19b3024ad2ba2d7
https://doi.org/10.1158/2767-9764.crc-22-0383
https://doi.org/10.1158/2767-9764.crc-22-0383
Autor:
Ingred Goretti Riça, Brian A. Joughin, Martha E. Teke, Tiffany R. Emmons, Alec M. Griffith, Laura A. Cahill, Valerie M. Banner-Goodspeed, Simon C. Robson, Jonathan M. Hernandez, Brahm H. Segal, Leo E. Otterbein, Carl J. Hauser, James A. Lederer, Michael B. Yaffe
Publikováno v:
Journal of Trauma and Acute Care Surgery. 94:187-196
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d961ab205c579d972756070151c9bcfa
https://doi.org/10.1097/ta.0000000000003823
https://doi.org/10.1097/ta.0000000000003823