Supplementary figures for 'Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses'

Autor: Als, Thomas Damm, Kurki, Mitja, Grove, Jakob, Voloudakis, Georgios, Therrien, Karen, Tasanko, Elisa, Nielsen, Trine Trollerup, Naamanka, Joonas, Veerapen, Kumar, Levey, Daniel, Bendl, Jaroslav, Bybjerg-Grauholm, Jonas, Zheng, Biao, Demontis, Ditte, Rosengren, Anders, Athanasiadis, Georgios, Bækved-Hansen, Marie, Qvist, Per, Bragi Walters, G., Thorgeirsson, Thorgeir, Stefansson, Hreinn, Musliner, Katherine L., Manikandan, Veera, Farajzadeh, Leila, Thirstrup, Janne Pia, J. Vilhjálmsson, Bjarni, McGrath, John, Mattheisen, Manuel, Meier, Sandra, Agerbo, Esben, Stefánsson, Kári, Nordentoft, Merete, Werge, Thomas, M. Hougaard, David, Bo Mortensen, Preben, Stein, Murray B., Gelernter, Joel, Hovatta, Iiris, Roussos, Panos, Daly, Mark J, Mors, Ole, Palotie, Aarno, Børglum, Anders D.

This document contians Supplementary Figures S1 – S10 and S19 – S28 for a manuscript titled ’Pathophysiologic inferences from 243 genetic loci for depression and risk prediction of recurrence and comorbid psychiatric disorders', submitted to Na

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Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Autor: Bjornsdottir, Gyda, Stefánsdóttir, Lilja, Thorleifsson, Gudmar, Sulem, Patrick, Norland, Kristjan, Ferkingstad, Egil, Oddsson, Asmundur, Zink, Florian, Lund, Sigrun H., Nawaz, Muhammad S., Bragi Walters, G., Skuladottir, Astros Th., Gudjonsson, Sigurjon A., Einarsson, Gudmundur, Halldorsson, Gisli H., Bjarnadottir, Valgerdur, Sveinbjornsson, Gardar, Helgadottir, Anna, Styrkársdóttir, Unnur, Gudmundsson, Larus J., Pedersen, Ole B., Hansen, Thomas Folkmann, Werge, Thomas, Banasik, Karina, Troelsen, Anders, Skou, Soren T., Thørner, Lise Wegner, Erikstrup, Christian, Nielsen, Kaspar Rene, Mikkelsen, Susan, Andersen, Steffen, Brunak, Søren, Burgdorf, Kristoffer, Hjalgrim, Henrik, Jemec, Gregor, Jennum, Poul, Johansson, Per Ingemar, Nielsen, Kasper Rene, Nyegaard, Mette, Bruun, Mie Topholm, Pedersen, Ole Birger, Dinh, Khoa Manh, Sørensen, Erik, Ostrowski, Sisse R., Johansson, Pär Ingemar, Gudbjartsson, Daniel F., Stefansson, Hreinn, Þorsteinsdóttir, Unnur, Larsen, Margit Anita Hørup, Didriksen, Maria, Sækmose, Susanne, Zeggini, Eleftheria, Hatzikotoulas, Konstantinos, Southam, Lorraine, Gilly, Arthur, Barysenka, Andrei, van Meurs, Joyce B. J., Boer, Cindy G., Uitterlinden, André G., Jonsson, Helgi, Ingvarsson, Thorvaldur, Esko, Tõnu, Mägi, Reedik, Teder-Laving, Maris, Ikegawa, Shiro, Terao, Chikashi, Takuwa, Hiroshi, Meulenbelt, Ingrid, Coutinho de Almeida, Rodrigo, Kloppenburg, Margreet, Tuerlings, Margo, Slagboom, P. Eline, Nelissen, Rob R. G. H. H., Valdes, Ana M., Mangino, Massimo, Tsezou, Aspasia, Zengini, Eleni, Alexiadis, George, Babis, George C., Cheah, Kathryn S. E., Wu, Tian T., Samartzis, Dino, Cheung, Jason Pui Yin, Sham, Pak Chung, Kraft, Peter, Kang, Jae Hee, Hveem, Kristian, Zwart, John-Anker, Luetge, Almut, Skogholt, Anne Heidi, Johnsen, Marianne B., Thomas, Laurent F., Winsvold, Bendik, Gabrielsen, Maiken E., Lee, Ming Ta Michael, Zhang, Yanfei, Lietman, Steven A., Shivakumar, Manu, Smith, George Davey, Tobias, Jonathan H., Hartley, April, Gaunt, Tom R., Zheng, Jie, Wilkinson, J. Mark, Steinberg, Julia, Morris, Andrew P., Jonsdottir, Ingileif, Bjornsson, Aron, Olafsson, Ingvar H., Ulfarsson, Elfar, Blondal, Josep, Vikingsson, Arnor, Brunak, Soren, Ullum, Henrik, Thorsteinsdottir, Unnur, Thorgeirsson, Thorgeir E., Stefansson, Kari, Consortium, DBDS Genetic, Consortium, GO

Publikováno v: Nature Communications, 13(1):634. Nature Publishing Group
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Bjornsdottir, G, Stefansdottir, L, Thorleifsson, G, Sulem, P, Norland, K, Ferkingstad, E, Oddsson, A, Zink, F, Lund, S H, Nawaz, M S, Bragi Walters, G, Skuladottir, A T, Gudjonsson, S A, Einarsson, G, Halldorsson, G H, Bjarnadottir, V, Sveinbjornsson, G, Helgadottir, A, Styrkarsdottir, U, Gudmundsson, L J, Pedersen, O B, Hansen, T F, Werge, T, Banasik, K, Troelsen, A, Skou, S T, Thørner, L W, Erikstrup, C, Nielsen, K R, Mikkelsen, S, Jonsdottir, I, Bjornsson, A, Olafsson, I H, Ulfarsson, E, Blondal, J, Vikingsson, A, Brunak, S, Ostrowski, S R, Ullum, H, Thorsteinsdottir, U, Stefansson, H, Gudbjartsson, D F, Thorgeirsson, T E, Stefansson, K, DBDS Genetic Consortium & GO Consortium 2022, ' Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology ', Nature Communications, vol. 13, 634 . https://doi.org/10.1038/s41467-022-28167-1
Bjornsdottir, G, Stefánsdóttir, L, Thorleifsson, G, Sulem, P, Norland, K, Ferkingstad, E, Oddsson, A, Zink, F, Lund, S H, Nawaz, M S, Bragi Walters, G, Skuladottir, A T, Gudjonsson, S A, Einarsson, G, Halldorsson, G H, Bjarnadottir, V, Sveinbjornsson, G, Helgadottir, A, Styrkársdóttir, U, Gudmundsson, L J, Pedersen, O B, Hansen, T F, Werge, T, Banasik, K, Troelsen, A, Skou, S T, Thørner, L W, Erikstrup, C, Nielsen, K R, Mikkelsen, S, Andersen, S, Brunak, S, Burgdorf, K, Hjalgrim, H, Jemec, G, Jennum, P, Johansson, P I, Nielsen, K R, Nyegaard, M, Bruun, M T, Pedersen, O B, Dinh, K M, Sørensen, E, Ostrowski, S R, Johansson, P I, Gudbjartsson, D F, Stefansson, H, Þorsteinsdóttir, U, Larsen, M A H, Didriksen, M, Sækmose, S, Zeggini, E, Hatzikotoulas, K, Southam, L, Gilly, A, Barysenka, A, van Meurs, J B J, Boer, C G, Uitterlinden, A G, Styrkársdóttir, U, Stefánsdóttir, L, Jonsson, H, Ingvarsson, T, Esko, T, Mägi, R, Teder-Laving, M, Ikegawa, S, Terao, C, Takuwa, H, Meulenbelt, I, Coutinho de Almeida, R, Kloppenburg, M, Tuerlings, M, Slagboom, P E, Nelissen, R R G H H, Valdes, A M, Mangino, M, Tsezou, A, Zengini, E, Alexiadis, G, Babis, G C, Cheah, K S E, Wu, T T, Samartzis, D, Cheung, J P Y, Sham, P C, Kraft, P, Kang, J H, Hveem, K, Zwart, J-A, Luetge, A, Skogholt, A H, Johnsen, M B, Thomas, L F, Winsvold, B, Gabrielsen, M E, Lee, M T M, Zhang, Y, Lietman, S A, Shivakumar, M, Smith, G D, Tobias, J H, Hartley, A, Gaunt, T R, Zheng, J, Wilkinson, J M, Steinberg, J, Morris, A P, Jonsdottir, I, Bjornsson, A, Olafsson, I H, Ulfarsson, E, Blondal, J, Vikingsson, A, Brunak, S, Ostrowski, S R, Ullum, H, Thorsteinsdottir, U, Stefansson, H, Gudbjartsson, D F, Thorgeirsson, T E, Stefansson, K, Consortium, DBDS G & Consortium, GO 2022, ' Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology ', Nature Communications, vol. 13, no. 1, 634 . https://doi.org/10.1038/s41467-022-28167-1
Bjornsdottir, G, Stefansdottir, L, Thorleifsson, G, Sulem, P, Norland, K, Ferkingstad, E, Oddsson, A, Zink, F, Lund, S H, Nawaz, M S, Bragi Walters, G, Skuladottir, A T, Gudjonsson, S A, Einarsson, G, Halldorsson, G H, Bjarnadottir, V, Sveinbjornsson, G, Helgadottir, A, Styrkarsdottir, U, Gudmundsson, L J, Pedersen, O B, Hansen, T F, Werge, T, Banasik, K, Troelsen, A, Skou, S T, Thørner, L W, Erikstrup, C, Nielsen, K R, Mikkelsen, S, DBDS Genetic Consortium, Jonsdottir, I, Bjornsson, A, Olafsson, I H, Ulfarsson, E, Blondal, J, Vikingsson, A, Brunak, S, Ostrowski, S R, Ullum, H, Thorsteinsdottir, U, Stefansson, H, Gudbjartsson, D F, Thorgeirsson, T E, Stefansson, K & Nyegaard, M 2022, ' Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology ', Nature Communications, vol. 13, no. 1, 634 . https://doi.org/10.1038/s41467-022-28167-1
Bjornsdottir, G, Stefánsdóttir, L, Thorleifsson, G, Sulem, P, Norland, K, Ferkingstad, E, Oddsson, A, Zink, F, Lund, S H, Nawaz, M S, Bragi Walters, G, Skuladottir, A T, Gudjonsson, S A, Einarsson, G, Halldorsson, G H, Bjarnadottir, V, Sveinbjornsson, G, Helgadottir, A, Styrkársdóttir, U, Gudmundsson, L J, Pedersen, O B, Hansen, T F, Werge, T, Banasik, K, Troelsen, A, Skou, S T, Thørner, L W, Erikstrup, C, Nielsen, K R, Mikkelsen, S, DBDS Genetic Consortium, GO Consortium, Jonsdottir, I, Bjornsson, A, Olafsson, I H, Ulfarsson, E, Blondal, J, Vikingsson, A, Brunak, S, Ostrowski, S R, Ullum, H, Thorsteinsdottir, U, Stefansson, H, Gudbjartsson, D F, Thorgeirsson, T E & Nyegaard, M 2022, ' Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology ', Nature Communications, vol. 13, 634 . https://doi.org/10.1038/s41467-022-28167-1

Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and interv

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Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Autor: Bjornsdottir, G. Stefansdottir, L. Thorleifsson, G. Sulem, P. Norland, K. Ferkingstad, E. Oddsson, A. Zink, F. Lund, S.H. Nawaz, M.S. Bragi Walters, G. Skuladottir, A.T. Gudjonsson, S.A. Einarsson, G. Halldorsson, G.H. Bjarnadottir, V. Sveinbjornsson, G. Helgadottir, A. Styrkarsdottir, U. Gudmundsson, L.J. Pedersen, O.B. Hansen, T.F. Werge, T. Banasik, K. Troelsen, A. Skou, S.T. Thørner, L.W. Erikstrup, C. Nielsen, K.R. Mikkelsen, S. Andersen, S. Brunak, S. Burgdorf, K. Hjalgrim, H. Jemec, G. Jennum, P. Johansson, P.I. Nielsen, K.R. Nyegaard, M. Bruun, M.T. Pedersen, O.B. Dinh, K.M. Sørensen, E. Ostrowski, S. Johansson, P.I. Gudbjartsson, D. Stefánsson, H. Þorsteinsdóttir, U. Larsen, M.A.H. Didriksen, M. Sækmose, S. Zeggini, E. Hatzikotoulas, K. Southam, L. Gilly, A. Barysenka, A. van Meurs, J.B.J. Boer, C.G. Uitterlinden, A.G. Styrkársdóttir, U. Stefánsdóttir, L. Jonsson, H. Ingvarsson, T. Esko, T. Mägi, R. Teder-Laving, M. Ikegawa, S. Terao, C. Takuwa, H. Meulenbelt, I. Coutinho de Almeida, R. Kloppenburg, M. Tuerlings, M. Slagboom, P.E. Nelissen, R.R.G.H.H. Valdes, A.M. Mangino, M. Tsezou, A. Zengini, E. Alexiadis, G. Babis, G.C. Cheah, K.S.E. Wu, T.T. Samartzis, D. Cheung, J.P.Y. Sham, P.C. Kraft, P. Kang, J.H. Hveem, K. Zwart, J.-A. Luetge, A. Skogholt, A.H. Johnsen, M.B. Thomas, L.F. Winsvold, B. Gabrielsen, M.E. Lee, M.T.M. Zhang, Y. Lietman, S.A. Shivakumar, M. Smith, G.D. Tobias, J.H. Hartley, A. Gaunt, T.R. Zheng, J. Wilkinson, J.M. Steinberg, J. Morris, A.P. Jonsdottir, I. Bjornsson, A. Olafsson, I.H. Ulfarsson, E. Blondal, J. Vikingsson, A. Brunak, S. Ostrowski, S.R. Ullum, H. Thorsteinsdottir, U. Stefansson, H. Gudbjartsson, D.F. Thorgeirsson, T.E. Stefansson, K. DBDS Genetic Consortium GO Consortium

Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report a genome-wide association study of back pain using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) and interv

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https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3025446

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Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Autor: Strawbridge, Rj, Dupuis, J, Prokopenko, I, Barker, A, Ahlqvist, E, Rybin, D, Petrie, Jr, Travers, Me, Bouatia Naji, N, Dimas, As, Nica, A, Wheeler, E, Chen, H, Voight, Bf, Taneera, J, Kanoni, S, Peden, Jf, Turrini, F, Gustafsson, S, Zabena, C, Almgren, P, Barker, Dj, Barnes, D, Dennison, Em, Eriksson, Jg, Eriksson, P, Eury, E, Folkersen, L, Fox, Cs, Frayling, Tm, Goel, A, Gu, Hf, Horikoshi, M, Isomaa, B, Jackson, Au, Jameson, Ka, Kajantie, E, Kerr Conte, J, Kuulasmaa, T, Kuusisto, J, Loos, Rj, Luan, J, Makrilakis, K, Manning, Ak, Martínez Larrad MT, Narisu, N, Nastase Mannila, M, Ohrvik, J, Osmond, C, Pascoe, L, Payne, F, Sayer, Aa, Sennblad, B, Silveira, A, Stancáková, A, Stirrups, K, Swift, Aj, Syvänen, Ac, Tuomi, T, van 't Hooft FM, Walker, M, Weedon, Mn, Xie, W, Zethelius, B, Diagram, Consortium, Giant, Consortium, Muther, Consortium, Cardiogram, Consortium, C4d, Consortium, Ongen, H, Mälarstig, A, Hopewell, Jc, Saleheen, D, Chambers, J, Parish, S, Danesh, J, Kooner, J, Ostenson, Cg, Lind, L, Cooper, Cc, Serrano Ríos, M, Ferrannini, E, Forsen, Tj, Clarke, R, Franzosi, Mg, Seedorf, U, Watkins, H, Froguel, P, Johnson, P, Deloukas, P, Collins, Fs, Laakso, M, Dermitzakis, Et, Boehnke, M, Mccarthy, Mi, Wareham, Nj, Groop, L, Pattou, F, Gloyn, Al, Dedoussis, Gv, Lyssenko, V, Meigs, Jb, Barroso, I, Watanabe, Rm, Ingelsson, E, Langenberg, C, Hamsten, A, Voight BF, Florez J. 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Publikováno v: Morris, A & Rudan, I & Campbell, H & Wilson, J 2011, ' Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes ', Diabetes, vol. 60, no. 10, pp. 2624-34 . https://doi.org/10.2337/db11-0415
Diabetes; Vol 60
Diabetes, Vol. 60, No 10 (2011) pp. 2624-34
Diabetes, 60(10), 2624-2634. American Diabetes Association Inc.
Diabetes, 60, 2624-34
Diabetes, 60(10), 2624-2634. AMER DIABETES ASSOC
Diabetes
Diabetes, 60, 10, pp. 2624-34
Diabetes, 60(10), 2624-2634
Strawbridge, R J, Dupuis, J, Prokopenko, I, Barker, A, Ahlqvist, E, Rybin, D, Petrie, J R, Travers, M E, Bouatia-Naji, N, Dimas, A S, Nica, A, Wheeler, E, Chen, H, Voight, B F, Taneera, J, Kanoni, S, Peden, J F, Turrini, F, Gustafsson, S, Zabena, C, Almgren, P, Barker, D J P, Barnes, D, Dennison, E M, Eriksson, J G, Eriksson, P, Eury, E, Folkersen, L, Fox, C S, Frayling, T M, Goel, A, Gu, H F, Horikoshi, M, Isomaa, B, Jackson, A U, Jameson, K A, Kajantie, E, Kerr-Conte, J, Kuulasmaa, T, Kuusisto, J, Loos, R J F, Luan, J, Makrilakis, K, Manning, A K, Martínez-Larrad, M T, Narisu, N, Mannila, M N, the DIAGRAM Consortium (Torsten Lauritzen, Niels Grarup; members), the GIANT Consortium (Daniel R. Witte; member), the MuTHER Consortium, the CARDIoGRAM Consortium & the C4D Consortium 2011, ' Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes ', Diabetes, vol. 60, no. 10, pp. 2624-2634 . https://doi.org/10.2337/db11-0415
Strawbridge, R J, Dupuis, J, Prokopenko, I, Barker, A, Ahlqvist, E, Rybin, D, Petrie, J R, Bouatia-Naji, N, Dimas, A S, Nica, A, Wheeler, E, Chen, H, Voight, B F, Taneera, J, Kanoni, S, Hottenga, J J, de Geus, E J C, Willemsen, G, Boomsma, D I, Forsen, T J, Clarke, R, Franzosi, M G, Seedorf, U, Watkins, H, Froguel, P, Johnson, P, Deloukas, P, Collins, F S, Laakso, M, Dermitzakis, E T, Boehnke, M, McCarthy, M I, Wareham, N J, Groop, L, Pattou, F, Gloyn, A L, Dedoussis, G V, Lyssenko, V, Meigs, J B, Barroso, I, Watanabe, R M, Ingelsson, E, Langenberg, C, Hamsten, A & Florez, J C 2011, ' Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes ', Diabetes, vol. 60, no. 10, pp. 2624-2634 . https://doi.org/10.2337/db11-0415

OBJECTIVE Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin proc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca4fdf7c5b7d3a200245a047f2fc720
https://hdl.handle.net/20.500.11820/d6fd0145-660e-41a0-96e6-84d3af65fb9b