A Tool for Reaction Monitoring in Real Time, the Development of a "Walk-Up Automated Reaction Profiling" System.

Autor: Alimuddin M; Department of Medicinal Chemistry, Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States., Bernier L; Department of Medicinal Chemistry, Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States., Braganza JF; Department of Medicinal Chemistry, Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States., Collins MR; Department of Medicinal Chemistry, Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States., Ornelas M; Department of Process Chemistry, Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States., Richardson PF; Department of Medicinal Chemistry, Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States., Sach N; Department of Medicinal Chemistry, Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States., Shariff D; Department of Medicinal Chemistry, Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States., Wang W; Department of Medicinal Chemistry, Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States., Yanovsky A; Department of Medicinal Chemistry, Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, California 92121, United States.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2024 Nov 22. Date of Electronic Publication: 2024 Nov 22.

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.

Autor: Bagal SK; Worldwide Medicinal Chemistry , Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., Andrews M; Pfizer Worldwide R&D U.K. , Sandwich , Kent CT13 9NJ , U.K., Bechle BM; Pfizer Worldwide R&D, Groton Laboratories , Eastern Point Road , Groton , Connecticut 06340 , United States., Bian J; Pfizer Worldwide R&D, Groton Laboratories , Eastern Point Road , Groton , Connecticut 06340 , United States., Bilsland J; Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., Blakemore DC; Worldwide Medicinal Chemistry , Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., Braganza JF; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Bungay PJ; Pharmacokinetics, Dynamics & Metabolism , Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., Corbett MS; Pfizer Worldwide R&D, Groton Laboratories , Eastern Point Road , Groton , Connecticut 06340 , United States., Cronin CN; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Cui JJ; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Dias R; Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., Flanagan NJ; Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., Greasley SE; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Grimley R; Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., James K; Peakdale Molecular , Discovery Park House, Ramsgate Road , Sandwich CT13 9ND , U.K., Johnson E; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Kitching L; Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., Kraus ML; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., McAlpine I; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Nagata A; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Ninkovic S; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Omoto K; Worldwide Medicinal Chemistry , Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., Scales S; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Skerratt SE; Worldwide Medicinal Chemistry , Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., Sun J; Pfizer Worldwide R&D, Groton Laboratories , Eastern Point Road , Groton , Connecticut 06340 , United States., Tran-Dubé M; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Waldron GJ; Pfizer Worldwide R&D U.K. , The Portway Building, Granta Park , Cambridge CB21 6GS , U.K., Wang F; Pfizer Worldwide R&D, La Jolla Laboratories , 10770 Science Center Drive , San Diego , California 92121 , United States., Warmus JS; Pfizer Worldwide R&D, Groton Laboratories , Eastern Point Road , Groton , Connecticut 06340 , United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Aug 09; Vol. 61 (15), pp. 6779-6800. Date of Electronic Publication: 2018 Jul 27.

Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.

Autor: McClure KF; Pfizer Global Research and Development, Groton Laboratories, CT 06340, USA. kim.f.mcclure@pfizer.com, Letavic MA, Kalgutkar AS, Gabel CA, Audoly L, Barberia JT, Braganza JF, Carter D, Carty TJ, Cortina SR, Dombroski MA, Donahue KM, Elliott NC, Gibbons CP, Jordan CK, Kuperman AV, Labasi JM, Laliberte RE, McCoy JM, Naiman BM, Nelson KL, Nguyen HT, Peese KM, Sweeney FJ, Taylor TJ, Trebino CE, Abramov YA, Laird ER, Volberg WA, Zhou J, Bach J, Lombardo F

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Aug 15; Vol. 16 (16), pp. 4339-44. Date of Electronic Publication: 2006 Jun 12.