Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Braedon McDonald"'
Autor:
Neha Sharma, Alex Chen, Leah Heinen, Ruth Liu, Dhruva J. Dwivedi, Ji Zhou, Manoj M. Lalu, Asher A. Mendelson, Braedon McDonald, Colin A. Kretz, Alison E. Fox-Robichaud, Patricia C. Liaw
Publikováno v:
Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Introduction Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predictor of poor outcom
Externí odkaz:
https://doaj.org/article/27fd2b1cf7f24f92a98ec9a101867c38
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
ABSTRACTFor many years, it has been hypothesized that pathological changes to the gut microbiome in critical illness is a driver of infections, organ dysfunction, and other adverse outcomes in the intensive care unit (ICU). The advent of contemporary
Externí odkaz:
https://doaj.org/article/57a02a607e174d9faf728b47f7ee20be
Autor:
Neha Sharma, Damian Chwastek, Dhruva J. Dwivedi, Jared Schlechte, Ian-Ling Yu, Braedon McDonald, Jaskirat Arora, Erblin Cani, Mikaela Eng, Doreen Engelberts, Eva Kuhar, Sarah K. Medeiros, Stephane L. Bourque, Gediminas Cepinskas, Sean E. Gill, Forough Jahandideh, Kimberly F. Macala, Sareh Panahi, Cynthia Pape, David Sontag, Janet Sunohara-Neilson, Dean A. Fergusson, Alison E. Fox-Robichaud, Patricia C. Liaw, Manoj M. Lalu, Asher A. Mendelson, for the National Preclinical Sepsis Platform, Sepsis Canada
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis Platform
Externí odkaz:
https://doaj.org/article/2a7fa924fb5b4658b0da38387de75a6e
Autor:
MengQi Zhang, Dean A. Fergusson, Rahul Sharma, Ciel Khoo, Asher A. Mendelson, Braedon McDonald, Kimberly F. Macala, Neha Sharma, Sean E. Gill, Kirsten M. Fiest, Christian Lehmann, Risa Shorr, Forough Jahandideh, Stephane L. Bourque, Patricia C. Liaw, Alison Fox-Robichaud, Manoj M. Lalu, on behalf of the Canadian Critical Care Translational Biology Group, the Sepsis Canada National Preclinical Sepsis Platform
Publikováno v:
Systematic Reviews, Vol 12, Iss 1, Pp 1-9 (2023)
Abstract Background The importance of investigating sex- and gender-dependent differences has been recently emphasized by major funding agencies. Notably, the influence of biological sex on clinical outcomes in sepsis is unclear, and observational st
Externí odkaz:
https://doaj.org/article/19f1ce8a2d3b487d9eec9135366362f3
Autor:
Christopher H Connor, Amanda Z Zucoloto, John T Munnoch, Ian-Ling Yu, Jukka Corander, Paul A Hoskisson, Braedon McDonald, Alan McNally
Publikováno v:
PLoS Biology, Vol 21, Iss 10, p e3002329 (2023)
Extra-intestinal pathogenic Escherichia coli (ExPEC) can cause a variety of infections outside of the intestine and are a major causative agent of urinary tract infections. Treatment of these infections is increasingly frustrated by antimicrobial res
Externí odkaz:
https://doaj.org/article/421262045a514acda1e6f5c3d06a6bd3
Autor:
Regula Burkhard, Mia Koegler, Kirsty Brown, Kirsten Wilson, Lukas F. Mager, Amanda Z. Zucoloto, Carolyn Thomson, Roopa Hebbandi Nanjundappa, Isla Skalosky, Shokouh Ahmadi, Braedon McDonald, Markus B. Geuking
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Healthy host-microbial mutualism with our intestinal microbiota relies to a large degree on compartmentalization and careful regulation of adaptive mucosal and systemic anti-microbial immune responses. However, commensal intestinal bacteria are never
Externí odkaz:
https://doaj.org/article/21972fc020164b9eba64f2065e45d74f
Autor:
Amanda Z. Zucoloto, Jared Schlechte, Aline Ignacio, Carolyn A. Thomson, Shannon Pyke, Ian-ling Yu, Markus B. Geuking, Kathy D. McCoy, Bryan G. Yipp, Mark R. Gillrie, Braedon McDonald
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112507- (2023)
Summary: During bloodstream infections, neutrophils home to the liver as part of an intravascular immune response to eradicate blood-borne pathogens, but the mechanisms regulating this crucial response are unknown. Using in vivo imaging of neutrophil
Externí odkaz:
https://doaj.org/article/00bd9fb6e81e42afa4bb4ea92accb295
Autor:
Asher A. Mendelson, Casey Lansdell, Alison E. Fox-Robichaud, Patricia Liaw, Jaskirat Arora, Jean-François Cailhier, Gediminas Cepinskas, Emmanuel Charbonney, Claudia dos Santos, Dhruva Dwivedi, Christopher G. Ellis, Dean Fergusson, Kirsten Fiest, Sean E. Gill, Kathryn Hendrick, Victoria T. Hunniford, Paulina M. Kowalewska, Karla Krewulak, Christian Lehmann, Kimberly Macala, John C. Marshall, Laura Mawdsley, Braedon McDonald, Ellen McDonald, Sarah K. Medeiros, Valdirene S. Muniz, Marcin Osuchowski, Justin Presseau, Neha Sharma, Sahar Sohrabipour, Janet Sunohara-Neilson, Gloria Vázquez-Grande, Ruud A. W. Veldhuizen, Donald Welsh, Brent W. Winston, Ryan Zarychanski, Haibo Zhang, Juan Zhou, Manoj M. Lalu, Sepsis Canada’s National Preclinical Sepsis Platform
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by precl
Externí odkaz:
https://doaj.org/article/9aeed005c2d54e4888a280f7bf96c4a3
Autor:
Rachita Panda, Fernanda V.S. Castanheira, Jared M. Schlechte, Bas G.J. Surewaard, Hanjoo Brian Shim, Amanda Z. Zucoloto, Zdenka Slavikova, Bryan G. Yipp, Paul Kubes, Braedon McDonald
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Acute respiratory distress syndrome (ARDS) is a life-threatening syndrome, constituted by respiratory failure and diffuse alveolar damage that results from dysregulated local and systemic immune activation, causing pulmonary vascular, parenchymal, an
Externí odkaz:
https://doaj.org/article/88cb1f5dc06b4c03bf9f453a926c1b52
Autor:
Jenna M Evans, Alexander Peever, Agnes Grudniewicz, Braedon McDonald, Asher A Mendelson, Manoj M Lalu
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273077 (2022)
IntroductionMedical advancements are slow to reach the patient bedside due to issues with knowledge translation from preclinical studies. Multi-laboratory preclinical studies are a promising strategy for addressing the methodological deficiencies tha
Externí odkaz:
https://doaj.org/article/3ff9b86de9f4481fb8dba77db57e8b9d