Výsledky vyhledávání - "Brady Sillman"

Akademický článek

Development of an extended action fostemsavir lipid nanoparticle

Autor: Farhana Islam, Srijanee Das, Md Ashaduzzaman, Brady Sillman, Pravin Yeapuri, Mohammad Ullah Nayan, David Oupický, Howard E. Gendelman, Bhavesh D. Kevadiya

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)

Abstract An extended action fostemsavir (FTR) lipid nanoparticle (LNP) formulation prevents human immunodeficiency virus type one (HIV-1) infection. This FTR formulation establishes a drug depot in monocyte-derived macrophages that extend the drug’

Externí odkaz: https://doaj.org/article/724d71a1580b4ef987734da42550c3e9

Zobrazit plný text záznamu

Akademický článek

Long-acting dolutegravir formulations prevent neurodevelopmental impairments in a mouse model

Autor: Emma G. Foster, Brady Sillman, Yutong Liu, Micah Summerlin, Vikas Kumar, Balasrinivasa R. Sajja, Adam R. Cassidy, Benson Edagwa, Howard E. Gendelman, Aditya N. Bade

Publikováno v: Frontiers in Pharmacology, Vol 14 (2023)

The World Health Organization has recommended dolutegravir (DTG) as a preferred first-line treatment for treatment naive and experienced people living with human immunodeficiency virus type one (PLWHIV). Based on these recommendations 15 million PLWH

Externí odkaz: https://doaj.org/article/ba6d4ed836814c72aee66959707f131a

Zobrazit plný text záznamu

Akademický článek

Polymer Delivery Systems for Long-Acting Antiretroviral Drugs

Autor: Mohammad Ullah Nayan, Sudipta Panja, Ashrafi Sultana, Lubaba A. Zaman, Lalitkumar K. Vora, Brady Sillman, Howard E. Gendelman, Benson Edagwa

Publikováno v: Pharmaceutics, Vol 16, Iss 2, p 183 (2024)

The success of long-acting (LA) drug delivery systems (DDSs) is linked to their biocompatible polymers. These are used for extended therapeutic release. For treatment or prevention of human immune deficiency virus type one (HIV-1) infection, LA DDSs

Externí odkaz: https://doaj.org/article/801fbe43738b4fdabac519e7aedc77ff

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Here, using animal models, Deodhar et al. single parenteral dose of dolutegravir (DTG) prodrug nanocrystals sustains drug protein-adjusted 90% inhibitory concentration for up to a year, without injection site reactions or systemic toxicities.

Externí odkaz: https://doaj.org/article/0e6c6ddce7834d67b915c46f752da67f

Zobrazit plný text záznamu

Akademický článek

Lipophilic nanocrystal prodrug-release defines the extended pharmacokinetic profiles of a year-long cabotegravir

Autor: Nagsen Gautam, JoEllyn M. McMillan, Devendra Kumar, Aditya N. Bade, Qiaoyu Pan, Tanmay A. Kulkarni, Wenkuan Li, Brady Sillman, Nathan A. Smith, Bhagya L. Dyavar Shetty, Adam Szlachetka, Benson J. Edagwa, Howard E. Gendelman, Yazen Alnouti

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Here, the authors provide a mechanism for an improved version of a nanoformulated myristoylated prodrug of cabotegravir (CAB), named NM2CAB, and its bioavailability, stability and pharmacokinetics in mice and rats performed in independent academic an

Externí odkaz: https://doaj.org/article/2bfe8aa999a043d6aa5d494a5ae8099d

Zobrazit plný text záznamu

Akademický článek

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)

Here, the authors show that sequential treatment with long-acting slow-effective release ART and AAV9- based delivery of CRISPR-Cas9 results in undetectable levels of virus and integrated DNA in a subset of humanized HIV-1 infected mice. This proof-o

Externí odkaz: https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b

Zobrazit plný text záznamu

Akademický článek

Creation of a long-acting nanoformulated dolutegravir

Autor: Brady Sillman, Aditya N. Bade, Prasanta K. Dash, Biju Bhargavan, Ted Kocher, Saumi Mathews, Hang Su, Georgette D. Kanmogne, Larisa Y. Poluektova, Santhi Gorantla, JoEllyn McMillan, Nagsen Gautam, Yazen Alnouti, Benson Edagwa, Howard E. Gendelman

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Current ART for treatment of HIV-1 infection requires a strict daily regimen adherence. Herein, the authors report the manufacture and characterization of a nanoformulated dolutegravir prodrug with improved cell and tissue penetration, a remarkable a

Externí odkaz: https://doaj.org/article/9fe938444e464eaea1e85845549ff241

Zobrazit plný text záznamu

CRISPR editing of CCR5 and HIV-1 facilitates viral elimination in antiretroviral drug-suppressed virus-infected humanized mice

Publikováno v: Proceedings of the National Academy of Sciences. 120

Treatment of HIV-1 ADA -infected CD34+ NSG-humanized mice with long-acting ester prodrugs of cabotegravir, lamivudine, and abacavir in combination with native rilpivirine was followed by dual CRISPR-Cas9 C-C chemokine receptor type five (CCR5) and HI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0521cb8aacc7a64087afd83a552e4482
https://doi.org/10.1073/pnas.2217887120

Zobrazit plný text záznamu

Recovery of Latent HIV-1 from Brain Tissue by Adoptive Cell Transfer in Virally Suppressed Humanized Mice

Autor: Larisa Y. Poluektova, Howard E. Gendelman, Brady Sillman, Prasanta K. Dash, Hang Su, Saumi Mathews, Sruthi Sravanam, Edward Makarov, Emiko Waight, Santhi Gorantla

Publikováno v: Journal of Neuroimmune Pharmacology. 16:796-805

Defining the latent human immunodeficiency virus type 1 (HIV-1) burden in the human brain during progressive infection is limited by sample access. Human hematopoietic stem cells (hu-HSCs)-reconstituted humanized mice provide an opportunity for this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d1bba541089ba4e61d025700ca3277
https://doi.org/10.1007/s11481-021-10011-w

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání