Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?

Autor: Grazia Daniela Femminella, Nicholas R. Livingston, Sanara Raza, Thalia van der Doef, Eleni Frangou, Sharon Love, Gail Busza, Valeria Calsolaro, Stefan Carver, Clive Holmes, Craig W. Ritchie, Robert M. Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben Underwood, Aparna Prasanna, Paul Koranteng, Salman Karim, Kehinde Junaid, Bernadette McGuinness, Anthony Peter Passmore, Ramin Nilforooshan, Ajayverma Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, Tricia Tan, Christian Holscher, John Harrison, David J. Brooks, Clive Ballard, Paul Edison

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)

Abstract Background Type 2 diabetes is a risk factor for Alzheimer’s disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insulin resistance on AD aetiopathogenesis in non-diabetic patients is still debated. Here we

Externí odkaz: https://doaj.org/article/a198863d79fc4206ad26cdc93baa3fb5

Correction to: Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: study protocol for a randomised controlled trial (ELAD study)

Autor: Grazia Daniela Femminella, Eleni Frangou, Sharon B. Love, Gail Busza, Clive Holmes, Craig Ritchie, Robert Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben R. Underwood, Aparna Prasanna, Paul Koranteng, Salman Karim, Kehinde Junaid, Bernadette McGuinness, Ramin Nilforooshan, Ajay Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, John Harrison, Christian Hölscher, David J. Brooks, Anthony Peter Passmore, Clive Ballard, Paul Edison

Publikováno v: Trials, Vol 21, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via the original article.

Externí odkaz: https://doaj.org/article/58617e946151483283103c608fa1cd03

Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects?

Autor: Stefan Carver, Naghma Malik, Craig W. Ritchie, Sanara Raza, John E Harrison, Salman Karim, Gregor Russell, David J. Brooks, Clive Holmes, George Tadros, Gail Busza, Vandana Mate, Sajeev Kshemendran, Anthony Peter Passmore, Basil H. Ridha, Thalia van der Doef, Lucy Knight, Kehinde Junaid, Elizabeth Coulthard, Ben Underwood, Hilary Archer, Tricia Tan, Sharon Love, Zuzana Walker, Paul Koranteng, Ajayverma Macharouthu, Bernadette McGuinness, Andrew Donaldson, Simon Thacker, Clive Ballard, Grazia Daniela Femminella, Paul Edison, Valeria Calsolaro, Aparna Prasanna, Ramin Nilforooshan, Nicholas R Livingston, Christian Hölscher, Robert M. Lawrence, Carol Bannister, Brady McFarlane, Eleni Frangou

Publikováno v: Femminella, G D, Livingston, N R, Raza, S, van der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, McFarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, McGuinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects? ', Alzheimer's Research and Therapy, vol. 13, 47 (2021) . https://doi.org/10.1186/s13195-021-00784-w
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Femminella, G D, Livingston, N R, Raza, S, Van Der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, Mcfarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, Mcguinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects? ', Alzheimer's research & therapy, vol. 13, no. 1 . https://doi.org/10.1186/s13195-021-00784-w
Femminella, G D, Livingston, N R, Raza, S, van der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, McFarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, McGuinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects? ', Alzheimer's Research & Therapy, vol. 13, no. 1, pp. 47 . https://doi.org/10.1186/s13195-021-00784-w
Femminella, G D, Livingston, N R, Raza, S, van der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, McFarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, McGuinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects? ', Alzheimer's research & therapy, vol. 13, 47 . https://doi.org/10.1186/s13195-021-00784-w

Background Type 2 diabetes is a risk factor for Alzheimer’s disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insulin resistance on AD aetiopathogenesis in non-diabetic patients is still debated. Here we evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abff61b5a79367e8f0ad4dae69e46610
https://research-information.bris.ac.uk/ws/files/277990943/s13195_021_00784_w.pdf

Relationship between spectral analysis, SUV and SUV Pons ratio as a measure of cerebral glucose metabolic rate in Alzheimer's disease

Autor: Stefan Carver, Craig W. Ritchie, Gregor Russell, Carol Bannister, Basil H. Ridha, Paul Edison, Naghma Malik, Sanara Raza, Ajayverma Macharouthu, John E Harrison, Grazia Daniela Femminella, Sajeev Kshemendran, Ramin Nilforooshan, Zuzana Walker, Clive Holmes, Kehinde Junaid, Simon Thacker, Joseph Nowell, Aparna Prasanna, Bernadette McGuinness, Elizabeth Coulthard, Andrew Donaldson, Hilary Archer, Paul Koranteng, Nicholas R Livingston, Vandana Mate, Robert M. Lawrence, Brady McFarlane, Eleanor G Blunt, Anthony Peter Passmore, Salman Karim, Clive Ballard, Lucy Knight, David J. Brooks, George Tadros, Ben Underwood

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31370f4afc727225670fa7d49530ae67
https://doi.org/10.1002/alz.046068

Behavioural symptoms in Alzheimer’s disease are associated with white matter lesions (WML) volume and are independent of atrophy and hypometabolism

Autor: Lucy Knight, Ajayverma Macharouthu, Thalia van der Doef, Paul Edison, Clive Holmes, Elizabeth Coulthard, Brady McFarlane, Naghma Malik, Gregor Russell, Ben Underwood, Salman Karim, Andrew Donaldson, Basil H. Ridha, Hilary Archer, Robert M. Lawrence, Bernadette McGuinness, Stefan Carver, Zuzana Walker, Craig W. Ritchie, John E Harrison, Simon Thacker, Anthony Peter Passmore, Ramin Nilforooshan, Sajeev Kshemendran, Carol Bannister, Aparna Prasanna, Kehinde Junaid, Paul Koranteng, David J. Brooks, Clive Ballard, George Tadros, Grazia Daniela Femminella, Vandana Mate

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c882551449eec3ae5b2714dc4998e6c
https://doi.org/10.1002/alz.045223