Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Brady M. Owen"'
Autor:
Cameron Fraser, Brady M. Owen
Publikováno v:
Frontiers in Aging, Vol 5 (2024)
No clear consensus has emerged from the literature on the gene expression changes that occur in human whole blood with age. In this study we compared whole blood ageing genes from the published literature with data on gene specificity for leukocyte s
Externí odkaz:
https://doaj.org/article/edb62e686d7247cdb178c49f9537a2c9
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
Functional decline with age contributes significantly to the burden of disease in developed countries. There is growing interest in the development of therapeutic interventions which slow or even reverse aging. Time and cost constraints prohibit the
Externí odkaz:
https://doaj.org/article/ab9d49be9d9b4336990381ec11a78a15
Autor:
Qi Zhang, Samuel C. Agius, Sarena F. Flanigan, Michael Uckelmann, Vitalina Levina, Brady M. Owen, Chen Davidovich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The polycomb repressive complex 2 (PRC2) is a histone methyltransferase regulating cell differentiation and identity. Here, the authors show that the vertebrate-specific PRC2 accessory subunit PALI1 facilitates substrate binding by the complex and el
Externí odkaz:
https://doaj.org/article/28e111a4e42249e7b0c766b5a9d29549
Autor:
Brady M. Owen, Samuel C. Agius, Vitalina Levina, Chen Davidovich, Sarena F. Flanigan, Michael Uckelmann, Qi Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
The polycomb repressive complex 2 (PRC2) is a histone methyltransferase that maintains cell identities. JARID2 is the only accessory subunit of PRC2 that known to trigger an allosteric activation of methyltransferase. Yet, this mechanism cannot be ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a9160fe7a1c4b9912d97527ae4ceaa6
https://doaj.org/article/28e111a4e42249e7b0c766b5a9d29549
https://doaj.org/article/28e111a4e42249e7b0c766b5a9d29549
Autor:
Brady M Owen, Chen Davidovich
Publikováno v:
Nucleic acids research. 50(9)
Polycomb group proteins predominantly exist in polycomb repressive complexes (PRCs) that cooperate to maintain the repressed state of thousands of cell-type-specific genes. Targeting PRCs to the correct sites in chromatin is essential for their funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e944a0fea1dbeac65ff69a46285ee52
https://pubmed.ncbi.nlm.nih.gov/35489059
https://pubmed.ncbi.nlm.nih.gov/35489059
Autor:
Brady M. Owen, Vitalina Levina, Qi Zhang, Chen Davidovich, Robert Warneford-Thomson, Roberto Bonasio, Benjamin A. Garcia, Ralf B. Schittenhelm, Nicholas J. McKenzie, Emma H Gail, Sarena F. Flanigan, Richard Lauman
Publikováno v:
Nature Structural & Molecular Biology. 26:237-247
Polycomb repressive complex 2 (PRC2) is a histone methyltransferase that maintains cell identity during development in multicellular organisms by marking repressed genes and chromatin domains. In addition to four core subunits, PRC2 comprises multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c8ed19f6e4eb6d5daeab6796b24323
https://doi.org/10.1038/s41594-019-0197-y
https://doi.org/10.1038/s41594-019-0197-y