Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Brady L. Stein"'
Publikováno v:
EBioMedicine, Vol 3, Iss C, Pp 17-25 (2016)
Despite the emergence of JAK inhibitors, there is a need for disease-modifying treatments for Philadelphia-negative myeloproliferative neoplasms (MPNs). JAK inhibitors ameliorate symptoms and address splenomegaly, but because of the heterogeneous con
Externí odkaz:
https://doaj.org/article/558eab85317c4d4da095b7a683c7cc62
Publikováno v:
Leukemia Research Reports, Vol 8, Iss C, Pp 11-13 (2017)
While growing use of comprehensive mutational analysis has led to the discovery of innumerable genetic alterations associated with various myeloid neoplasms, the under-recognized phenomenon of genetic heterogeneity within such neoplasms creates a pot
Externí odkaz:
https://doaj.org/article/14691dfc428445959d855ecab2010562
Autor:
Diana Saleiro, Swarna Mehrotra, Barbara Kroczynska, Elspeth M. Beauchamp, Pawel Lisowski, Beata Majchrzak-Kita, Tushar D. Bhagat, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Ewa M. Kosciuczuk, Darren P. Baker, Chunfa Jie, Nadereh Jafari, Craig B. Thompson, Ross L. Levine, Eleanor N. Fish, Amit K. Verma, Leonidas C. Platanias
Publikováno v:
Cell Reports, Vol 11, Iss 4, Pp 605-617 (2015)
We provide evidence that the Unc-51-like kinase 1 (ULK1) is activated during engagement of the type I interferon (IFN) receptor (IFNR). Our studies demonstrate that the function of ULK1 is required for gene transcription mediated via IFN-stimulated r
Externí odkaz:
https://doaj.org/article/634475be033c4f94ad88728b9a41870d
Autor:
Brady L. Stein, Donna M. Williams, Christine O’Keefe, Ophelia Rogers, Roxann G. Ingersoll, Jerry L. Spivak, Amit Verma, Jarek P. Maciejewski, Michael A. McDevitt, Alison R. Moliterno
Publikováno v:
Haematologica, Vol 96, Iss 10 (2011)
Background The myeloproliferative neoplasms, essential thrombocytosis, polycythemia vera and primary myelofibrosis, share the same acquired genetic lesion, but the concept of JAK2 V617F serving as the sole lesion responsible for these neoplasms is un
Externí odkaz:
https://doaj.org/article/973542ce9e5d4ee99e958d209f7a50b8
Autor:
Brady L. Stein, Donna M. Williams, Nae-Yuh Wang, Ophelia Rogers, Mary Ann Isaacs, Naveen Pemmaraju, Jerry L. Spivak, Alison R. Moliterno
Publikováno v:
Haematologica, Vol 95, Iss 7 (2010)
Background The JAK2V617F allele burden is a variable measure, determined by the frequency of mitotic recombination events and the expansion of JAK2V617F clones. Since variability in the JAK2V617F allele burden is partly responsible for the distinct p
Externí odkaz:
https://doaj.org/article/7927a7304a3e430fbf3fb6c21b2987c4
Autor:
Brady L, Stein
Publikováno v:
Leukemia & Lymphoma. 64:292-299
The management of myelofibrosis has improved following approval of the JAK1/JAK2 inhibitor, ruxolitinib. This agent laid the foundation for JAK inhibitor therapy, yet limitations have included myelosuppression and other adverse events (skin cancer, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa5e658dd6738ed124da47fd6998755
https://doi.org/10.1080/10428194.2022.2136970
https://doi.org/10.1080/10428194.2022.2136970
Autor:
Oluwatobi Odetola, Karlyn A. Martin, Marie Dreyer, Priya Rajan, Anaadriana Zakarija, Brady L. Stein
Publikováno v:
British Journal of Haematology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d1e53ec73e9ec1452681acbdb9491f5
https://doi.org/10.1111/bjh.18888
https://doi.org/10.1111/bjh.18888
Autor:
Brady L. Stein
Publikováno v:
Current Hematologic Malignancy Reports. 16:483-489
The management of myelofibrosis is risk-adapted when considering transplant eligibility and symptom-directed, prioritizing the most burdensome symptoms for the patient. Unfortunately, myelofibrosis-anemia is common, multifactorial in its origin, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9052860c14e5b5f465d2b6c139a977b9
https://doi.org/10.1007/s11899-021-00651-3
https://doi.org/10.1007/s11899-021-00651-3
Autor:
Aaron T. Gerds, Jason Gotlib, Haris Ali, Prithviraj Bose, Andrew Dunbar, Amro Elshoury, Tracy I. George, Krishna Gundabolu, Elizabeth Hexner, Gabriela S. Hobbs, Tania Jain, Catriona Jamieson, Paul R. Kaesberg, Andrew T. Kuykendall, Yazan Madanat, Brandon McMahon, Sanjay R. Mohan, Kalyan V. Nadiminti, Stephen Oh, Animesh Pardanani, Nikolai Podoltsev, Lindsay Rein, Rachel Salit, Brady L. Stein, Moshe Talpaz, Pankit Vachhani, Martha Wadleigh, Sarah Wall, Dawn C. Ward, Mary Anne Bergman, Cindy Hochstetler
Publikováno v:
Journal of the National Comprehensive Cancer Network : JNCCN. 20(9)
The classic Philadelphia chromosome–negative myeloproliferative neoplasms (MPN) consist of myelofibrosis, polycythemia vera, and essential thrombocythemia and are a heterogeneous group of clonal blood disorders characterized by an overproduction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21221c5f4b85cef3af9888b0ca5cd39
https://pubmed.ncbi.nlm.nih.gov/36075392
https://pubmed.ncbi.nlm.nih.gov/36075392
Autor:
Elias Hohlastos, Kush R. Desai, Brady L. Stein, Ahsun Riaz, Justin R. Boike, Abhinav Talwar, Riad Salem, Haripriya Maddur, Juan Carlos Garcia Pagan, Robert J. Lewandowski, Gabriel M. Knight, Jeffrey R. Clark, Ahmed Gabr, Bartley Thornburg, Samdeep K. Mouli, Daniel Ganger
Publikováno v:
Hepatology. 74:2735-2744
Background and aims Extrahepatic portal vein occlusion (EHPVO) from portal vein thrombosis is a rare condition associated with substantial morbidity and mortality. The purpose of this study is to investigate the efficacy of transjugular intrahepatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be3cfdd5f4c60070e81a6b4cebfbc53
https://doi.org/10.1002/hep.31915
https://doi.org/10.1002/hep.31915