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pro vyhledávání: '"Brady G. Vigliarolo"'
Autor:
Jennifer N. K. Nyarko, Brady G. Vigliarolo, Shusheng Wang, Morshed A. Chowdhury, Christopher P. Phenix, Darrell D. Mousseau
Publikováno v:
Bioorganic chemistry. 92
Cathepsin B plays key roles in tumor progression with its overexpression being associated with invasive and metastatic phenotypes and is a primary target of protease activated antibody-directed prodrug therapy. It therefore represents a potential the
Autor:
Cody C. McMillan, Christopher P. Phenix, Brady G. Vigliarolo, Morshed A. Chowdhury, Shardul Bhilocha, Ingeborg Zehbe, Ignace Adolfo Moya
Publikováno v:
Journal of Medicinal Chemistry. 57:6092-6104
Cathepsin B (CTB) is a cysteine protease believed to be an important therapeutic target or biomarker for several diseases including aggressive cancer, arthritis, and parasitic infections. The development of probes capable of assessing CTB activity in