Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Bradley T. Tangonan"'
Autor:
Willard Lew, Ute Hoch, Jeffrey A. Silverman, Stacey A. Heumann, Sheryl N. Ivy, Stuart Lam, Minna Bui, Hanan Emily, Thomas O'Brien, W. Michael Flanagan, Robert A. Elling, Bradley T. Tangonan, Hans E. Purkey, Heman Lee, Min Zhong, Subramanian Baskaran, Kristin M. Zimmerman, Pietro Taverna, Robert S. McDowell, Amy D. Fung, Wang Shen, Shannon O. Harris, Michael J. Romanowski, Wenjin Yang, Jeffrey W. Jacobs, Joshua C. Yoburn, Darin Allen, Chul Yu, Johan D. Oslob
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5158-5161
This Letter describes the discovery and key structure-activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors. 2-Aminobenzimidazole serves as a bioisostere of the biaryl urea residue of SNS-314 (1c), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3f97920374b8e6e5f11cd9c42ab0bc
https://doi.org/10.1016/j.bmcl.2009.07.016
https://doi.org/10.1016/j.bmcl.2009.07.016
Autor:
Shannon O. Harris, Stacey A. Heumann, Jeffrey W. Jacobs, William Michael Flanagan, Subramanian Baskaran, Kristin M. Zimmerman, Darin Allen, Minna Bui, Michael J. Romanowski, Bradley T. Tangonan, Johan D. Oslob, Robert S. McDowell, Wang Shen, Chris E Lawrence, Juli N. Teague, Willard Lew, Michelle M. Sopko, Michelle A. Nannini, Jeffrey A. Silverman, Joshua C. Yoburn, Chul Yu, Min Zhong, Hanan Emily, Ute Hoch, Amy D. Fung, Joni Lam, Robert A. Elling, Thomas O'Brien
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(17)
This communication describes the discovery of a novel series of Aurora kinase inhibitors. Key SAR and critical binding elements are discussed. Some of the more advanced analogues potently inhibit cellular proliferation and induce phenotypes consisten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6628e44d37788613c268d76ba8583b8
https://pubmed.ncbi.nlm.nih.gov/18678489
https://pubmed.ncbi.nlm.nih.gov/18678489
Autor:
Bradley T. Tangonan, David M. Penny, Jeremy T. Smith, Thomas O'Brien, Diana E. Vincent, Robert A. Elling, Stig Hansen, Michael J. Romanowski
Publikováno v:
Protein expression and purification. 54(1)
Aurora kinases have recently become some of the most intensely pursued oncology targets for the design of small-molecule inhibitors. Most of the active Aurora-A protein variants are currently being expressed from baculoviruses in insect cells, while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08da48323ed6e93d55d28e1cc71dfb9
https://pubmed.ncbi.nlm.nih.gov/17434748
https://pubmed.ncbi.nlm.nih.gov/17434748