Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Bradley T. Keller"'
Autor:
Renger G. Tiessen, Ciara A. Kennedy, Bradley T. Keller, Nancy Levin, Lisette Acevedo, Bronislava Gedulin, Andre A. van Vliet, Alejandro Dorenbaum, Melissa Palmer
Publikováno v:
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-17 (2018)
Abstract Background Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol. Apical sodium-dependent bile acid transporter (ASBT) inhibition in the terminal ileu
Externí odkaz:
https://doaj.org/article/3d128a07b8274c4e9e7f28c5bb378c0b
Autor:
B. Ganesh Bhat, Stephen R. Rapp, Judith A. Beaudry, Nida Napawan, Dustie N. Butteiger, Kerri A. Hall, Christopher L. Null, Yi Luo, Bradley T. Keller
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 9, Pp 1614-1621 (2003)
Blocking intestinal bile acid absorption by inhibiting the apical sodium codependent bile acid transporter (ASBT) is a target for increasing hepatic bile acid synthesis and reducing plasma LDL cholesterol. SC-435 was identified as a potent inhibitor
Externí odkaz:
https://doaj.org/article/71ee37a00399428f83a355972e50266c
Autor:
Dawn E. Telford, Jane Y. Edwards, Sara M. Lipson, Brian Sutherland, P.Hugh R. Barrett, John R. Burnett, Elaine S. Krul, Bradley T. Keller, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 5, Pp 943-952 (2003)
Discovery of the ileal apical sodium-dependent bile acid transporter (ASBT) permitted development of specific inhibitors of bile acid reabsorption, potentially a new class of cholesterol-lowering agents. In the present study, we tested the hypothesis
Externí odkaz:
https://doaj.org/article/7c8fb27920264b34957b9666d6ecd11d
Autor:
Tiffany Shi, Alexander Miethke, Wujuan Zhang, Kenneth D.R. Setchell, Anil G. Jegga, Shana White, Shiva Kumar Shanmukhappa, Celine S. Lages, Amy Taylor, Rebekah Karns, Bradley T. Keller, Stephenson Nkinin, Julia Simmons
Publikováno v:
Hepatology. 63:512-523
Deficiency for multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low-phospholipid “toxic” bile causing progressive cholestasis. We hypothesize that pharmacological inhibition of the ileal, apical sodium-dep
Autor:
Andre van Vliet, Bradley T. Keller, Melissa Palmer, Alejandro Dorenbaum, Ciara Kennedy, Renger G. Tiessen, Lisette Acevedo, Bronislava Gedulin, Nancy Levin
Publikováno v:
BMC Gastroenterology
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-17 (2018)
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-17 (2018)
Background Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol. Apical sodium-dependent bile acid transporter (ASBT) inhibition in the terminal ileum may fac
Autor:
Jeffrey T. Borenstein, Toni A. Steiner, Bradley T. Keller, Craig M. Neville, Eric Park, Ernest S. Kim, Katherine M. Kulig, Hideaki Shimada, Hiroyuki Eda, Krupali Patel
Publikováno v:
Digestive Diseases and Sciences. 57:1152-1162
Hepatic stellate cells (HSC) play a major role in the progression of liver fibrosis. The aim of our study was to investigate whether rat HSC cultured on a nanofiber membrane (NM) retain their quiescent phenotype during both short- and long-term cultu
Publikováno v:
The Journal of Nutritional Biochemistry. 16:722-728
We have demonstrated that SC-435, an apical sodium codependent bile acid transporter (ASBT) inhibitor, lowers plasma low-density lipoprotein cholesterol (LDL-C) concentrations in guinea pigs. The purpose of this study was to further examine the hypoc
Discovery of Potent, Nonsystemic Apical Sodium-Codependent Bile Acid Transporter Inhibitors (Part 2)
Autor:
Miller Raymond E, Wei Huang, Horng-Chih Huang, Jay S. Trivedi, Scott R. Both, Nigam P. Rath, David B. Reitz, Deborah A. Mischke, Len F. Lee, Samuel J. Tremont, Steve R. Rapp, Danny J. Garland, Claude Jones, Banerjee Shyamal C, Matthew W. Mahoney, Theresa Fletcher, Michael B. Tollefson, Karen Regina, Emily J. Reinhard, Grace M. Wagner, Mark E. Smith, Judy Beaudry, J.-H Li, Kevin C. Glenn, Bradley T. Keller, Robert E. Manning, Kevin J. Koeller, Joe R. Schuh, Kolodziej Steve A, William F. Vernier, Carpenter Andrew J, Ching-Cheng Wang
Publikováno v:
Journal of Medicinal Chemistry. 48:5853-5868
In the preceding paper several compounds were reported as potent apical sodium-codependent bile acid transporter (ASBT) inhibitors. Since the primary site for active bile acid reabsorption is via ASBT, which is localized on the luminal surface of the
Autor:
Khaldoun G. Tarakji, Bradley T. Keller, Ming Zhang, Eric J. Topol, A. Michael Lincoff, Farhad Forudi, Zhongmin Zhou, Mark E. Smith, Xiaorong Zhou, Alane T. Koki, Kai Wang, Marc S. Penn
Publikováno v:
Journal of Cardiovascular Pharmacology. 45:61-67
The inflammation in response to vascular injury is becoming increasingly recognized as a potential contributor to restenosis. Cyclooxygenase-2 (COX-2) is the inducible form of cyclooxygenase and has been shown to be involved in the proinflammatory re
Autor:
Yi Luo, Bradley T. Keller, B. Ganesh Bhat, Kerri A. Hall, Stephen R. Rapp, Christopher L. Null, Nida Napawan, Dustie N Butteiger, Judith A. Beaudry
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 9, Pp 1614-1621 (2003)
Blocking intestinal bile acid absorption by inhibiting the apical sodium codependent bile acid transporter (ASBT) is a target for increasing hepatic bile acid synthesis and reducing plasma LDL cholesterol. SC-435 was identified as a potent inhibitor