Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bradley T, Falk"'
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Multispecific therapeutic proteins come in a variety of formats, including bi- and tri-specific antibodies, dual-variable domain antibodies, and CrossMabs. These multivalent proteins are engineered to interact with multiple therapeutic target protein
Externí odkaz:
https://doaj.org/article/4fcb4e63df00416eaca1675b22f3f367
Autor:
Mingyue Li, Bradley T. Falk, Xingyu Lu, Ryan Schroder, Mark Mccoy, Wei Xu, Daniel H. Yin, Marian E. Gindy, Suzanne M. D’Addio, Yongchao Su
Publikováno v:
Molecular Pharmaceutics. 19:3267-3278
Antimicrobial preservatives are used as functional excipients in multidose formulations of biological therapeutics to destroy or inhibit the growth of microbial contaminants, which may be introduced by repeatedly administering doses. Antimicrobial ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9539c01a6d93547ca89360ed1314446
https://doi.org/10.1021/acs.molpharmaceut.2c00449
https://doi.org/10.1021/acs.molpharmaceut.2c00449
Publikováno v:
Journal of Pharmaceutical Sciences. 109:922-926
Formulations that can increase the dissociation of insulin oligomers into monomers/dimers are important considerations in the development of ultra-rapid-acting insulins with faster onset and shorter duration of actions. Here we present a novel strate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c932e2ccec63ec636359977daf3c34
https://doi.org/10.1016/j.xphs.2019.07.025
https://doi.org/10.1016/j.xphs.2019.07.025
Autor:
Bradley T. Falk, Marc Andre Bailly, Yingkai Liang, Mark A. McCoy, Laurence Fayadat-Dilman, Dmitri A. Pissarnitski, Dennis Feng, Songnian Lin, Fahimeh Raoufi, Ahmet Kekec, Lin Yan
Publikováno v:
ChemBioChem. 21:315-319
NMR measurements of rotational and translational diffusion are used to characterize the solution behavior of a wide variety of therapeutic proteins and peptides. The timescales of motions sampled in these experiments reveal complicated intrinsic solu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bd05f3038162fadb318559950a3e8ce
https://doi.org/10.1002/cbic.201900296
https://doi.org/10.1002/cbic.201900296
Autor:
Bradley T. Falk, Nikolay V. Dokholyan, David D. Mowrey, Paul J. Sapienza, Konstantin I. Popov, Andrew L. Lee
Publikováno v:
Biochemistry. 58:3302-3313
Thymidylate synthase (TS) is a dimeric enzyme conserved in all life forms that exhibits the allosteric feature of half-the-sites activity. Neither the reason for nor the mechanism of this phenomenon is understood. We used a combined nuclear magnetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51b7ea1e5c70d0b63b83022fcd8cd1a
https://doi.org/10.1021/acs.biochem.9b00486
https://doi.org/10.1021/acs.biochem.9b00486
Publikováno v:
Journal of pharmaceutical sciences. 109(1)
Formulations that can increase the dissociation of insulin oligomers into monomers/dimers are important considerations in the development of ultra-rapid-acting insulins with faster onset and shorter duration of actions. Here we present a novel strate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::604278a504bacf36c4948e29f818c6da
https://pubmed.ncbi.nlm.nih.gov/31449814
https://pubmed.ncbi.nlm.nih.gov/31449814
Publikováno v:
Chembiochem : a European journal of chemical biology. 20(7)
Characterizing changes to structure and behavior is an important aspect of therapeutic protein development. NMR spectroscopy is well suited to study interactions and higher-order structure that could impact biological function and safety. We used NMR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba81ad34a27112c8ce33e267c6789c0d
https://pubmed.ncbi.nlm.nih.gov/30515922
https://pubmed.ncbi.nlm.nih.gov/30515922
Publikováno v:
Journal of the American Chemical Society. 137:14260-14263
Thymidylate synthase (TSase) is a clinically important enzyme because it catalyzes synthesis of the sole de novo source of deoxy-thymidylate. Without this enzyme, cells die a “thymineless death” since they are starved of a crucial DNA synthesis p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49d150909f825b39cd8ce1d2e5b7861d
https://doi.org/10.1021/jacs.5b10128
https://doi.org/10.1021/jacs.5b10128
Publikováno v:
ChemBioChem. 20:859-859
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf39b2fc08ca39cb73b733052211be8f
https://doi.org/10.1002/cbic.201900133
https://doi.org/10.1002/cbic.201900133
Allosteric communication is critical for protein function and cellular homeostasis, and it can be exploited as a strategy for drug design. However, unlike many protein–ligand interactions, the structural basis for the long-range communication that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9f6c024c88a6ee035bf8908a8117f5
