Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Bradley Spencer–Dene"'
Autor:
E. Josue Ruiz, Linxiang Lan, Markus Elmar Diefenbacher, Eva Madi Riising, Clive Da Costa, Atanu Chakraborty, Joerg D. Hoeck, Bradley Spencer-Dene, Gavin Kelly, Jean-Pierre David, Emma Nye, Julian Downward, Axel Behrens
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-RasG12D–induced lung adenocarcinoma, we induc
Externí odkaz:
https://doaj.org/article/d1bdf75630574d7b9e1c28b13a237cf7
Autor:
Rute M.M. Ferreira, Rocio Sancho, Hendrik A. Messal, Emma Nye, Bradley Spencer-Dene, Richard K. Stone, Gordon Stamp, Ian Rosewell, Alberto Quaglia, Axel Behrens
Publikováno v:
Cell Reports, Vol 21, Iss 4, Pp 966-978 (2017)
Summary: The cell of origin of pancreatic ductal adenocarcinoma (PDAC) has been controversial. Here, we show that identical oncogenic drivers trigger PDAC originating from both ductal and acinar cells with similar histology but with distinct pathophy
Externí odkaz:
https://doaj.org/article/6fdd133864f14223b3c2f5abfdfe6119
Autor:
Cynthia Yu-Wai-Man, Bradley Spencer-Dene, Richard M. H. Lee, Kim Hutchings, Erika M. Lisabeth, Richard Treisman, Maryse Bailly, Scott D. Larsen, Richard R. Neubig, Peng T. Khaw
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway represents a promising therapeutic target to prevent fibrosis. We have tested the effects of new pharmacological inhibitors of MRTF/SRF signalling in a precl
Externí odkaz:
https://doaj.org/article/d0d09e6ee5ac462a80dbec12fafe4e2c
Autor:
Miguel M. Murillo, Sareena Rana, Bradley Spencer-Dene, Emma Nye, Gordon Stamp, Julian Downward
Publikováno v:
Cell Reports, Vol 25, Iss 13, Pp 3545-3553.e2 (2018)
Summary: RAS family GTPases contribute directly to the regulation of type I phosphoinositide 3-kinases (PI3Ks) via RAS-binding domains in the PI3K catalytic p110 subunits. Disruption of this domain of p110α impairs RAS-mutant-oncogene-driven tumor f
Externí odkaz:
https://doaj.org/article/98e10355f3784f7bace00dc80db13e03
Autor:
Ivan Quétier, Jacqueline J.T. Marshall, Bradley Spencer-Dene, Sylvie Lachmann, Adele Casamassima, Claudio Franco, Sarah Escuin, Joseph T. Worrall, Priththivika Baskaran, Vinothini Rajeeve, Michael Howell, Andrew J. Copp, Gordon Stamp, Ian Rosewell, Pedro Cutillas, Holger Gerhardt, Peter J. Parker, Angus J.M. Cameron
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 440-448 (2016)
In animals, the protein kinase C (PKC) family has expanded into diversely regulated subgroups, including the Rho family-responsive PKN kinases. Here, we describe knockouts of all three mouse PKN isoforms and reveal that PKN2 loss results in lethality
Externí odkaz:
https://doaj.org/article/96edc553b94e4ce0be7befee57ac296c
Autor:
Yaiza del Pozo Martin, Danielle Park, Anassuya Ramachandran, Luigi Ombrato, Fernando Calvo, Probir Chakravarty, Bradley Spencer-Dene, Stefanie Derzsi, Caroline S. Hill, Erik Sahai, Ilaria Malanchi
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2456-2469 (2015)
During metastatic colonization, tumor cells must establish a favorable microenvironment or niche that will sustain their growth. However, both the temporal and molecular details of this process remain poorly understood. Here, we found that metastatic
Externí odkaz:
https://doaj.org/article/7e576db4abd54f95ae80761afb321229
Autor:
Zoé Vincent-Mistiaen, Ahmed Elbediwy, Hannah Vanyai, Jennifer Cotton, Gordon Stamp, Emma Nye, Bradley Spencer-Dene, Gareth J Thomas, Junhao Mao, Barry Thompson
Publikováno v:
eLife, Vol 7 (2018)
Squamous cell carcinoma (SCC) can progress to malignant metastatic cancer, including an aggressive subtype known as spindle cell carcinoma (spSCC). spSCC formation involves epithelial-to-mesenchymal transition (EMT), yet the molecular basis of this e
Externí odkaz:
https://doaj.org/article/6de980c2e1784fdbabf6b0279c684b74
Autor:
Federica Lorenzi, Roya Babaei-Jadidi, Jonathan Sheard, Bradley Spencer-Dene, Abdolrahman S Nateri
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Colorectal cancer (CRC) is one of the top three cancer-related causes of death worldwide. FBXW7 is a known tumor-suppressor gene, commonly mutated in CRC and in a variety of other epithelial tumors. Low expression of FBXW7 is also associated with poo
Externí odkaz:
https://doaj.org/article/bda010818adb48e3a9949922dd217d74
Autor:
Despina Stamataki, Maxine Holder, Christine Hodgetts, Rosemary Jeffery, Emma Nye, Bradley Spencer-Dene, Douglas J Winton, Julian Lewis
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24484 (2011)
The stem cells of the small intestine are multipotent: they give rise, via transit-amplifying cell divisions, to large numbers of columnar absorptive cells mixed with much smaller numbers of three different classes of secretory cells--mucus-secreting
Externí odkaz:
https://doaj.org/article/74e36a9ee792498fb303407fd1ed16cc
Autor:
May Yin Lee, Victor Racine, Peter Jagadpramana, Li Sun, Weimiao Yu, Tiehua Du, Bradley Spencer-Dene, Nicole Rubin, Lendy Le, Delphine Ndiaye, Saverio Bellusci, Klaus Kratochwil, Jacqueline M Veltmaat
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26242 (2011)
Mammary gland development starts in utero with one or several pairs of mammary rudiments (MRs) budding from the surface ectodermal component of the mammalian embryonic skin. Mice develop five pairs, numbered MR1 to MR5 from pectoral to inguinal posit
Externí odkaz:
https://doaj.org/article/cf683fb6f14542ad9c8c1c00980b962f