Výsledky vyhledávání - "Bradley S. Wahle"

Chronic toxicity and carcinogenicity testing in the Sprague–Dawley rat of a prospective insect repellant (KBR 3023) using the dermal route of exposure

Autor: W. R. Christenson, G.K. Sangha, Claire Croutch, Stephen G. Lake, Larry P. Sheets, Bradley S. Wahle

Publikováno v: Toxicology. 142:41-56

The chronic toxicology and carcinogenic potential of 1-(1-methyl-propoxycarbonyl)-2-(2-hydroxyethyl)-piperidine (KBR 3023), a prospective new insect repellent intended for human use, was studied in rats using the dermal route of application. Relying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2e4aafe8de23c54d7b0aa6e4072f2e
https://doi.org/10.1016/s0300-483x(99)00129-8

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Carcinogenicity testing in the CD-1 mouse of a prospective insect repellant (KBR 3023) using the dermal route of exposure

Autor: Larry P. Sheets, Laura E. Elcock, Bradley S. Wahle, G.K. Sangha, W. R. Christenson

Publikováno v: Toxicology. 142:29-39

The carcinogenic potential of 1-(1-methyl-propoxycarbonyl)-2-(2-hydroxyethyl)-piperidine (KBR 3023), a prospective new insect repellent intended for human use, was studied in mice using the dermal route of application. Relying upon the toxicology pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd2de05cd35efbe3e2e9d77045808b3
https://doi.org/10.1016/s0300-483x(99)00122-5

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Urinary Physiologic and Chemical Metabolic Effects on the Urothelial Cytotoxicity and Potential DNA Adducts ofo-Phenylphenol in Male Rats

Autor: Emily M. Garland, Lora L. Arnold, Margaret K. St. John, Stephen G. Lake, Bradley S. Wahle, Raymond A. Smith, W. Russ Christenson, Samuel M. Cohen, Debra A. McNett, Martin Cano, Michael J. Bartels

Publikováno v: Toxicology and Applied Pharmacology. 150:402-413

ortho-Phenylphenol (OPP), a fungicide and antibacterial agent with food residues, is carcinogenic to rat bladder. The present studies provide information on changes in urinary composition and urinary metabolites, urothelial cytotoxicity and regenerat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac1039e5009fd0472255967cb420a0e
https://doi.org/10.1006/taap.1998.8435

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Tributyl Phosphate Effects on Urine and Bladder Epithelium in Male Sprague–Dawley Rats

Autor: Lora L. Arnold, M. Cano, Bradley S. Wahle, W. R. Christenson, Samuel M. Cohen, M. St John

Publikováno v: Fundamental and Applied Toxicology. 40:247-255

Tributyl phosphate (TBP) produces tumors of the bladder urothelium in rats at high doses (700 and 3000 ppm), with greater effects in males than in females. TBP does not produce tumors in mice and it is nongenotoxic. The dose response of TBP effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f067dae8e501b3f6f66771d2fef3a9
https://doi.org/10.1006/faat.1997.2391

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Evidence of Chemical Stimulation of Hepatic Metabolism by an Experimental Acetanilide (FOE 5043) Indirectly Mediating Reductions in Circulating Thyroid Hormone Levels in the Male Rat

Autor: Stephen G. Lake, G.K. Sangha, B. D. Becker, W. R. Christenson, J.H. Thyssen, Barry P. Stuart, P. D. Dass, D. L. Van Goethem, K. D. Moore, Bradley S. Wahle

Publikováno v: Fundamental and Applied Toxicology. 29:251-259

N -(4-Fluorophenyl)- N -(1-methylethyl)-2-[[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]oxy]acetamide (FOE 5043) is a new acetanilide-type herbicide undergoing regulatory testing. Previous work in this laboratory suggested that FOE 5043-induced reducti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8cceba7bcd768e598a177d5468d8d9
https://doi.org/10.1006/faat.1996.0029

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Extrathyroidally Mediated Changes in Circulating Thyroid Hormone Concentrations in the Male Rat Following Administration of an Experimental Oxyacetamide (FOE 5043)

Autor: H.D. Hoang, B. D. Becker, D.L. Vangoethem, W. R. Christenson, K. D. Moore, J.H. Thyssen, Barry P. Stuart, Stephen G. Lake, G.K. Sangha, Bradley S. Wahle, P. D. Dass

Publikováno v: Toxicology and Applied Pharmacology. 132:253-262

Evidence of increased hepatic metabolizing capacity coupled with reductions in serum thyroxine (T4) levels were noted in the rat during preliminary toxicity studies with FOE 5043, an oxyacetamide with herbicidal properties. These findings were consis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c7152519cc98c862dffa70a5598e53
https://doi.org/10.1006/taap.1995.1106

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Tumors in long-term rat studies associated with microchip animal identification devices

Autor: Barry P. Stuart, Stephen G. Lake, Herbert E. Hoss, Thomas F. Hastings, Donna M. Millard, Laura E. Elcock, Bradley S. Wahle, Robert E. Mueller, Kerry Crabb

Publikováno v: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 52(6)

Summary Tumors surrounding implanted microchip animal identification devices were noted in two separate chronic toxicity/oncogenicity studies using F344 rats. The tumors occurred at a low incidence rate (approximately 1 percent), but did result in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b52e2d3c4f9e777d7a8aee22557104
https://pubmed.ncbi.nlm.nih.gov/11256750

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