Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Bradley S Launikonis"'
Autor:
Michael J. Maxwell, Chris Thekkedam, Cedric Lamboley, Yanni K.-Y. Chin, Theo Crawford, Jennifer J. Smith, Junyu Liu, Xinying Jia, Irina Vetter, Derek R. Laver, Bradley S. Launikonis, Angela Dulhunty, Eivind A. B. Undheim, Mehdi Mobli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Insect toxins with tandem repeats of neurotoxin domains have been found with enhanced receptor avidity. Here, the authors describe a bivalent toxin from remipede venom that targets ryanodine receptors, a rare target for animal venoms.
Externí odkaz:
https://doaj.org/article/ecfef30c1c5e4dc1ab651ec6f5d81576
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Store-operated calcium entry (SOCE) plays a pivotal role in skeletal muscle physiology as, when impaired, the muscle is prone to early fatigue and the development of different myopathies. A chronic mode of slow SOCE activation is carried by stromal i
Externí odkaz:
https://doaj.org/article/01b3fd0510a4441d9317eb0ad6e28886
Autor:
Crystal Seng, Luke Pearce, Aldo Meizoso-Huesca, Daniel P. Singh, Robyn M. Murphy, Cedric R. Lamboley, Bradley S. Launikonis
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1285-C1289
Ca2+ is an integral component of the functional and developmental regulation of the mitochondria. In skeletal muscle, Ca2+ is reported to modulate the rate of ATP resynthesis, regulate the expression of peroxisome proliferator-activated receptor-gamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d390e02ddb7831983faacc5a7e86b494
https://doi.org/10.1152/ajpcell.00092.2022
https://doi.org/10.1152/ajpcell.00092.2022
Autor:
Tanya R. Cully, Robyn M. Murphy, Llion Roberts, Truls Raastad, Robert G. Fassett, Jeff S. Coombes, Izzy Jayasinghe, Bradley S. Launikonis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Abstract High-force eccentric exercise results in sustained increases in cytoplasmic Ca2+ levels ([Ca2+]cyto), which can cause damage to the muscle. Here we report that a heavy-load strength training bout greatly alters the structure of the membrane
Externí odkaz:
https://doaj.org/article/ac5dc5c88c904369b9a94eb7648f2c36
Autor:
Daniel P. Singh, Luke Pearce, Rocky H. Choi, Aldo Meizoso-Huesca, Stefan G. Wette, John W. Scott, Cedric R. Lamboley, Robyn M. Murphy, Bradley S. Launikonis
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Resting skeletal muscle generates heat for endothermy in mammals but not amphibians, while both use the same Ca 2+ -handling proteins and membrane structures to conduct excitation–contraction coupling apart from having different ryanodine receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01dcd7dcca02bd3aba3e5270488ae9f3
https://doi.org/10.1073/pnas.2117503120
https://doi.org/10.1073/pnas.2117503120
Autor:
Yi-Lin Cheng, Jong-Sung Park, Silvia Manzanero, Yuri Choi, Sang-Ha Baik, Eitan Okun, Mathias Gelderblom, David Yang-Wei Fann, Tim Magnus, Bradley S. Launikonis, Mark P. Mattson, Christopher G. Sobey, Dong-Gyu Jo, Thiruma V. Arumugam
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 286-295 (2014)
Recent findings suggest that Notch-1 signaling contributes to neuronal death in ischemic stroke, but the underlying mechanisms are unknown. Hypoxia inducible factor-1α (HIF-1α), a global regulator of cellular responses to hypoxia, can interact with
Externí odkaz:
https://doaj.org/article/35c6cf2c2f4247e9ab8381698e73d964
Publikováno v:
Journal of General Physiology. 154
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::127dccbf793493e30d3a9460ee517fb1
https://doi.org/10.1085/jgp.20211299404062022c
https://doi.org/10.1085/jgp.20211299404062022c
Autor:
Jack U. Flanagan, Ryan E. Yoast, Gregory R. Monteith, Bradley S. Launikonis, Irina Vetter, Iman Azimi, Ping Xin, Mohamed Trebak, Jeevak Sopanrao Kapure, Martin Johnson, Mark R. Ashton, Aldo Meizoso-Huesca, Benjamin P. Ross, Xuexin Zhang, Silke B. Chalmers, Ralph J. Stevenson, William A. Denny
Publikováno v:
ACS Pharmacology & Translational Science. 3:135-147
Store-operated calcium (Ca2+) entry is an important homeostatic mechanism in cells, whereby the release of Ca2+ from intracellular endoplasmic reticulum stores triggers the activation of a Ca2+ influx pathway. Mediated by Orai1, this Ca2+ influx has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b28ef4e60f28fbdda21f83956ca5309e
https://doi.org/10.1021/acsptsci.9b00081
https://doi.org/10.1021/acsptsci.9b00081
Autor:
Luke Pearce, Aldo Meizoso‐Huesca, Crystal Seng, Cedric R. Lamboley, Daniel P. Singh, Bradley S. Launikonis
Publikováno v:
The Journal of Physiology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a498616a02ab29a2ea34d5847e1571be
https://doi.org/10.1113/jp279512
https://doi.org/10.1113/jp279512
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The evolution of mammals to use skeletal muscle as a source of heat allowed them to spread to all parts of the globe. The generation of heat requires increased adenosine triphosphate (ATP) hydrolysis in the resting muscle in a regulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4aa994ba9ad31e4e7c66c815219d50
https://doi.org/10.1073/pnas.2119203119
https://doi.org/10.1073/pnas.2119203119