Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Bradley Rs Broughton"'
Autor:
Mariane Bertagnolli, Francine Z. Marques, Rikeish R. Muralitharan, Joanne A. O’Donnell, Chudan Xu, Hamdi A. Jama, Bradley Rs Broughton, Geoffrey A. Head
Publikováno v:
British Journal of Pharmacology. 179:918-937
Elevated blood pressure (BP), or hypertension, is the main risk factor for cardiovascular disease. As a multifactorial and systemic disease that involves multiple organs and systems, hypertension remains a challenging disease to study. Models of hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985dd1a06bffa114f773c1c77d145b99
https://doi.org/10.1111/bph.15650
https://doi.org/10.1111/bph.15650
Publikováno v:
Free Radical Research. 48:940-947
Influenza A virus infects resident alveolar macrophages in the respiratory tract resulting in Toll like receptor 7 (TLR7) activation that triggers an inflammatory response to resolve the infection. Macrophages are also major sources of reactive oxyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1db0c01691d641a44a89016cc35a39b
https://doi.org/10.3109/10715762.2014.927579
https://doi.org/10.3109/10715762.2014.927579
Autor:
Charles E. Norton, Nikki L. Jernigan, Bradley Rs Broughton, Benjimen R. Walker, Thomas C. Resta
Publikováno v:
Antioxidants & Redox Signaling. 18:1777-1788
Aims: Chronic hypoxia (CH) enhances depolarization-induced myofilament Ca2+ sensitization and resultant pulmonary arterial constriction through superoxide (O2−)-dependent stimulation of RhoA. Because NAD(P)H oxidase (NOX) has been implicated in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c44a7febadb743dfa22db32549eada
https://doi.org/10.1089/ars.2012.4836
https://doi.org/10.1089/ars.2012.4836
Autor:
Ross Vlahos, Chistopher Chan, Michelle L. Halls, Eunice To, Steven Bozinovski, Patrick C. Reading, Raymond Luong, Tim Quach, Grant R Drummond, Paul T. King, Christopher G. Sobey, Stavros Selemidis, Doug A. Brooks, Sharon R Lewin, Christopher J.H. Porter, Bradley Rs Broughton, John J. O'Leary, Renee Van de Sluis, Malcolm R. Starkey
Publikováno v:
10.1 Respiratory Infections.
Reactive oxygen species (ROS) promote influenza pathogenicity by an unknown mechanism. Our aims were to determine 1) the site and enzymatic source of subcellular ROS generation and 2) the impact of ROS on the pathogenesis of virus infection. To do th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6abecdaf39a7dd1553521cd121912ba0
https://doi.org/10.1183/13993003.congress-2016.pa2600
https://doi.org/10.1183/13993003.congress-2016.pa2600
Autor:
Christopher G. Sobey, Seyoung Lee, Vanessa H Brait, Grant R Drummond, Bradley Rs Broughton, Jennifer Rivera
Publikováno v:
Brain Research. 1372:169-179
This study sought to identify potential targets for acute stroke therapy that can be exploited pharmacologically beyond the current 4.5h time limit for clinical administration of recombinant tissue-plasminogen activator. We used PCR arrays to initial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aafff15970f678c8f3b9888ec989353
https://doi.org/10.1016/j.brainres.2010.11.087
https://doi.org/10.1016/j.brainres.2010.11.087
Autor:
Megan A Evans, Bradley Rs Broughton, Euan M. Wallace, Grant R Drummond, Christopher G. Sobey, Rebecca Lim
Publikováno v:
Perinatal Stem Cells ISBN: 9781493911172
Ischemic stroke is a crippling disease with few treatment options available. Thus there is an urgent need for novel therapies that can prevent or reverse the damaging effects of stroke. A promising experimental approach is stem cell therapy. Stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae8541a93ea48d637d1df260db6c3e48
https://doi.org/10.1007/978-1-4939-1118-9_20
https://doi.org/10.1007/978-1-4939-1118-9_20
Autor:
Bradley Rs Broughton, Christopher G. Sobey, Claudia A. McCarthy, Jennifer K. Callaway, Antony Vinh, Robert E Widdop
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 60(6)
We have demonstrated previously that pretreatment with an angiotensin II type 2 receptor (AT 2 R) agonist is neuroprotective against a subsequent stroke independent of any changes in blood pressure. Therefore, in the current study, we have examined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38cbf2b21568973ba69386abcce150bc
https://pubmed.ncbi.nlm.nih.gov/23090776
https://pubmed.ncbi.nlm.nih.gov/23090776
Autor:
Katherine R. Martin, John Thundyil, Christopher G. Sobey, Thiruma V. Arumugam, Bradley Rs Broughton, Alicia Corlett, Melanie April Pritchard, Vanessa H Brait, Grant R Drummond, Helena Kim
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 10, p e47841 (2012)
PLoS ONE, Vol 7, Iss 10, p e47841 (2012)
Background and Purpose: The Down syndrome candidate region 1 (DSCR1) gene is located on human chromosome 21 and its protein is over-expressed in brains of Down syndrome individuals. DSCR1 can modulate the activity of calcineurin, a phosphatase abunda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b922ed58d475895aa866a3f5a49051c
http://europepmc.org/articles/PMC3483156
http://europepmc.org/articles/PMC3483156
Autor:
David Smith, Bruce S. Gardiner, Sarah L Thompson, Amany Abdelkader, John F. Bertram, Jennifer P. Ngo, Roger G. Evans, Bradley Rs Broughton
Publikováno v:
American journal of physiology. Renal physiology. 303(5)
To understand how geometric factors affect arterial-to-venous (AV) oxygen shunting, a mathematical model of diffusive oxygen transport in the renal cortex was developed. Preglomerular vascular geometry was investigated using light microscopy (providi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee9bc47522a6f214adbd8dc856e0d56
https://pubmed.ncbi.nlm.nih.gov/22674022
https://pubmed.ncbi.nlm.nih.gov/22674022
Autor:
Chantelle V. Gardiner-Mann, Thiruma V. Arumugam, Sung-Chun Tang, Bradley Rs Broughton, Alyson A. Miller, Elizabeth Guida, Vanessa H Brait, Grant R Drummond, Seyoung Lee, Christopher G. Sobey
Publikováno v:
Neurosignals, Vol 21, Iss 3-4, Pp 229-239 (2012)
The novel estrogen receptor, G protein-coupled estrogen receptor (GPER, previously named GPR30), is widely distributed throughout the male and female brain and, thus, could potentially play a role in estrogen-mediated neuroprotective effects in disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7446d5e655fd8a14f2bb16377bf983d1
https://pubmed.ncbi.nlm.nih.gov/22869326
https://pubmed.ncbi.nlm.nih.gov/22869326