Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Bradley R Groveman"'
Autor:
Christina D Orrú, Bradley R Groveman, Andrew G Hughson, Tomás Barrio, Kachi Isiofia, Brent Race, Natalia C Ferreira, Pierluigi Gambetti, David A Schneider, Kentaro Masujin, Kohtaro Miyazawa, Bernardino Ghetti, Gianluigi Zanusso, Byron Caughey
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1012175 (2024)
Prions or prion-like aggregates such as those composed of PrP, α-synuclein, and tau are key features of proteinopathies such as prion, Parkinson's and Alzheimer's diseases, respectively. Their presence on solid surfaces may be biohazardous under som
Externí odkaz:
https://doaj.org/article/e41f9f194a98464797ac114a7b488335
Autor:
Sarah Vascellari, Christina D Orrù, Bradley R Groveman, Sabiha Parveen, Giuseppe Fenu, Giada Pisano, Giuseppe Piga, Giulia Serra, Valentina Oppo, Daniela Murgia, Andrea Perra, Fabrizio Angius, Andrew G Hughson, Cathryn L Haigh, Aldo Manzin, Giovanni Cossu, Byron Caughey
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6, p e1011456 (2023)
Abnormal deposition of α-synuclein is a key feature and biomarker of Parkinson's disease. α-Synuclein aggregates can propagate themselves by a prion-like seeding-based mechanism within and between tissues and are hypothesized to move between the in
Externí odkaz:
https://doaj.org/article/f1359ada37b94233a8723855297fbd28
Autor:
Chase Baune, Bradley R Groveman, Andrew G Hughson, Tina Thomas, Barry Twardoski, Suzette Priola, Bruce Chesebro, Brent Race
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290325 (2023)
Prion diseases are transmissible, fatal neurologic diseases that include Creutzfeldt-Jakob Disease (CJD) in humans, chronic wasting disease (CWD) in cervids, bovine spongiform encephalopathy (BSE) in cattle and scrapie in sheep. Prions are extremely
Externí odkaz:
https://doaj.org/article/4beb6980eb9a42c2962ac0f3ac764288
Autor:
Simote T Foliaki, Anna Smith, Benjamin Schwarz, Eric Bohrnsen, Catharine M Bosio, Katie Williams, Christina D Orrú, Hailey Lachenauer, Bradley R Groveman, Cathryn L Haigh
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010565 (2023)
Fatal familial insomnia (FFI) is a rare neurodegenerative disease caused by a dominantly inherited single amino acid substitution (D178N) within the prion protein (PrP). No in vitro human brain tissue model for this disease has previously been availa
Externí odkaz:
https://doaj.org/article/5f44df8f953e4e0d8120b3a7928318d2
Autor:
Anna Smith, Bradley R Groveman, Clayton Winkler, Katie Williams, Ryan Walters, Jue Yuan, Wenquan Zou, Karin Peterson, Simote T Foliaki, Cathryn L Haigh
Publikováno v:
PLoS ONE, Vol 17, Iss 10, p e0277051 (2022)
Prion diseases are a group of rare, transmissible, and invariably fatal neurodegenerative diseases that affect both humans and animals. The cause of these diseases is misfolding of the prion protein into pathological isoforms called prions. Of all hu
Externí odkaz:
https://doaj.org/article/920ac69e16944f7f8f246830c303222a
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009747 (2021)
Externí odkaz:
https://doaj.org/article/7a9007754e69457bafde80810fc26b4f
Autor:
Simote T Foliaki, Brent Race, Katie Williams, Chase Baune, Bradley R Groveman, Cathryn L Haigh
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259597 (2021)
Prion diseases are progressive, neurodegenerative diseases affecting humans and animals. Also known as the transmissible spongiform encephalopathies, for the hallmark spongiform change seen in the brain, these diseases manifest increased oxidative da
Externí odkaz:
https://doaj.org/article/23606fe40de04f528270e8cb9d2e7f10
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 6, Pp 1019-1020 (2020)
Externí odkaz:
https://doaj.org/article/9d0ab35d2375425bb03b132d8f7949d1
Hippocampal protein kinase D1 is necessary for DHPG-induced learning and memory impairments in rats.
Autor:
Wei Wang, Florian Duclot, Bradley R Groveman, Nicole Carrier, Haifa Qiao, Xiao-Qian Fang, Hui Wang, Wenkuan Xin, Xing-Hong Jiang, Michael W Salter, Xin-Sheng Ding, Mohamed Kabbaj, Xian-Min Yu
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195095 (2018)
BackgroundUnderstanding molecular mechanisms underlying the induction of learning and memory impairments remains a challenge. Recent investigations have shown that the activation of group I mGluRs (mGluR1 and mGluR5) in cultured hippocampal neurons b
Externí odkaz:
https://doaj.org/article/715f30ef33074c678a955ad5a7673164
Autor:
Bradley R Groveman, Gregory J Raymond, Katrina J Campbell, Brent Race, Lynne D Raymond, Andrew G Hughson, Christina D Orrú, Allison Kraus, Katie Phillips, Byron Caughey
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006623 (2017)
Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrPSc. This effe
Externí odkaz:
https://doaj.org/article/e156212488e54190893c2a5f0e53b24d