Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Bradley R Cairns"'
Autor:
Graham JM Hickey, Candice L Wike, Xichen Nie, Yixuan Guo, Mengyao Tan, Patrick J Murphy, Bradley R Cairns
Publikováno v:
eLife, Vol 11 (2022)
Vertebrate embryos achieve developmental competency during zygotic genome activation (ZGA) by establishing chromatin states that silence yet poise developmental genes for subsequent lineage-specific activation. Here, we reveal the order of chromatin
Externí odkaz:
https://doaj.org/article/0f077f5c7e104e5a86be865a70d5caec
Autor:
Patrick J Murphy, Jingtao Guo, Timothy G Jenkins, Emma R James, John R Hoidal, Thomas Huecksteadt, Dallin S Broberg, James M Hotaling, David F Alonso, Douglas T Carrell, Bradley R Cairns, Kenneth I Aston
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008756 (2020)
Paternal cigarette smoke (CS) exposure is associated with increased risk of behavioral disorders and cancer in offspring, but the mechanism has not been identified. Here we use mouse models to investigate mechanisms and impacts of paternal CS exposur
Externí odkaz:
https://doaj.org/article/f1c39d09b6eb4aa9abd6df5fcde7696e
Publikováno v:
eLife, Vol 9 (2020)
SWI/SNF-family chromatin remodeling complexes, such as S. cerevisiae RSC, slide and eject nucleosomes to regulate transcription. Within nucleosomes, stiff DNA sequences confer spontaneous partial unwrapping, prompting whether and how SWI/SNF-family r
Externí odkaz:
https://doaj.org/article/1e3be44cef52403c94493ea6187be6ec
Publikováno v:
eLife, Vol 4 (2015)
ISWI family chromatin remodelers typically organize nucleosome arrays, while SWI/SNF family remodelers (RSC) typically disorganize and eject nucleosomes, implying an antagonism that is largely unexplored in vivo. Here, we describe two independent gen
Externí odkaz:
https://doaj.org/article/d3b2e526e71741b5a4fbe3148eadee59
Publikováno v:
PLoS Genetics, Vol 10, Iss 7, p e1004458 (2014)
Recent evidence demonstrates a role for paternal aging on offspring disease susceptibility. It is well established that various neuropsychiatric disorders (schizophrenia, autism, etc.), trinucleotide expansion associated diseases (myotonic dystrophy,
Externí odkaz:
https://doaj.org/article/ae3f77a707f34631980ecf0911fe0f17
Autor:
Ravi K Alla, Bradley R Cairns
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85648 (2014)
Recent genomic approaches have revealed that the repertoire of RNA Pol III-transcribed genes varies in different human cell types, and that this variation is likely determined by a combination of the chromatin landscape, cell-specific DNA-binding tra
Externí odkaz:
https://doaj.org/article/3bb651df3c4a435d9af94ba82495acfa
Autor:
Edward J. Grow, Ying Liu, Zhiqiang Fan, Iuri Viotti Perisse, Tayler Patrick, Misha Regouski, Sean Shadle, Irina Polejaeva, Kenneth L. White, Bradley R. Cairns
Publikováno v:
bioRxiv
Reprogramming of the gamete into a developmentally competent embryo identity is a fundamental aspect of preimplantation development. One of the most important processes of this reprogramming is the transcriptional awakening during embryonic genome ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9476acc51ea565dd3e153415513692c8
https://europepmc.org/articles/PMC10120652/
https://europepmc.org/articles/PMC10120652/
Autor:
Sunil Sharma, Joshua D. Schiffman, Bradley R. Cairns, William T. Lowrance, John M. O’Shea, Brian Dalley, Lisa M. Pappas, Alexis Weston, Andrew Butterfield, Timothy J. Parnell, Daniel J. Albertson, Sumati Gupta
Histone deacetylase (HDAC) inhibition has sporadic clinical efficacy in urothelial carcinoma; the genomic basis for clinical response is not known. In two separate phase I clinical trials testing pharmacokinetic aspects of HDAC inhibitors in advanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec4e1e38652dd7a79529d4ba01a40db4
https://doi.org/10.1158/1535-7163.c.6537834.v1
https://doi.org/10.1158/1535-7163.c.6537834.v1
Autor:
Sunil Sharma, Joshua D. Schiffman, Bradley R. Cairns, William T. Lowrance, John M. O’Shea, Brian Dalley, Lisa M. Pappas, Alexis Weston, Andrew Butterfield, Timothy J. Parnell, Daniel J. Albertson, Sumati Gupta
GSEA with Hallmark gene sets performed on transcriptional changes in HT1197 cells treated with panobinostat for 48 hours. A. Top 6 downregulated GSEA signatures B. Top 6 upregulated GSEA signatures C. GSEA HT1197 vs UMUC3 ( comparison of transcriptom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3dc70c008073ca019badbdc66ba909
https://doi.org/10.1158/1535-7163.22504713
https://doi.org/10.1158/1535-7163.22504713
Autor:
Sunil Sharma, Joshua D. Schiffman, Bradley R. Cairns, William T. Lowrance, John M. O’Shea, Brian Dalley, Lisa M. Pappas, Alexis Weston, Andrew Butterfield, Timothy J. Parnell, Daniel J. Albertson, Sumati Gupta
Heat map of top 50 genes affected in HT1197 cells when treated with panobinostat at 48 hours log2 gene expression change(HT1197 A-B and C represent control replicates, HT1197 Pano A, B, C represent treated replicates). For the cell lines with replica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a56af42c97fabe3bfcd48fef55e9f8
https://doi.org/10.1158/1535-7163.22504722
https://doi.org/10.1158/1535-7163.22504722