Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Bradley R, Miller"'
Autor:
Grace E. Paquelet, Kassandra Carrion, Clay O. Lacefield, Pengcheng Zhou, Rene Hen, Bradley R. Miller
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102074- (2023)
Summary: In vivo brainstem imaging with miniature microscopy has been challenging due to surgical difficulty, high motion, and correlated activity between neurons. Here, we present a protocol for brainstem imaging in freely moving mice using the dors
Externí odkaz:
https://doaj.org/article/fbbbb997aec24f0492747bb31544f922
Autor:
Bradley R Miller, Yan Kung
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208419 (2018)
Mevalonate kinase (MK) is a key enzyme of the mevalonate pathway, which produces the biosynthetic precursors for steroids, including cholesterol, and isoprenoids, the largest class of natural products. Currently available crystal structures of MK fro
Externí odkaz:
https://doaj.org/article/1683e2414e774fcca8e3c754669b4d53
Publikováno v:
ACS Chem Biol
Nonribosomal peptide synthetases (NRPSs) are remarkable modular enzymes that synthesize peptide natural products. The condensation (C) domain catalyzes the key amide bond-forming reaction, but structural characterization with bound donor and acceptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946ca8dbf29df9cbd3485e6c84885903
https://doi.org/10.1021/acschembio.0c00411
https://doi.org/10.1021/acschembio.0c00411
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 2, Pp 415-420 (2011)
Increases in vesicular glutamate transporter (VGLUT) levels are observed after a variety of insults including hypoxic injury, stress, methamphetamine treatment, and in genetic seizure models. Such overexpression can cause an increase in the amount of
Externí odkaz:
https://doaj.org/article/1cc06a01299a4613a0fdc05019808c18
Autor:
Grace E, Paquelet, Kassandra, Carrion, Clay O, Lacefield, Pengcheng, Zhou, René, Hen, Bradley R, Miller
Publikováno v:
Neuron. 110:2664-2679.e8
The serotonin system modulates a wide variety of emotional behaviors and states, including reward processing, anxiety, and social interaction. To reveal the underlying patterns of neural activity, we visualized serotonergic neurons in the dorsal raph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904fd48110a7f5f4cad3d921bb98db17
https://doi.org/10.1016/j.neuron.2022.05.015
https://doi.org/10.1016/j.neuron.2022.05.015
Autor:
Bradley R. Miller, Yan Kung
Publikováno v:
Biochemistry. 57:654-662
The key mevalonate pathway enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR) uses the cofactor NAD(P)H to reduce HMG-CoA to mevalonate in the production of countless metabolites and natural products. Although inhibition of HMGR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e396c53124c68f700a9c18c1cbfffc8f
https://doi.org/10.1021/acs.biochem.7b00999
https://doi.org/10.1021/acs.biochem.7b00999
Autor:
Bradley R. Miller
Publikováno v:
Biological Psychiatry. 88:e23-e24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1cf44f5536ed42e73e56e07a5c5989
https://doi.org/10.1016/j.biopsych.2020.06.016
https://doi.org/10.1016/j.biopsych.2020.06.016
Publikováno v:
Cell reports. 39(4)
The cerebral cortex is spontaneously active, but the function of this ongoing activity remains unclear. To test whether spontaneous activity encodes learned experiences, we measured the response of neuronal populations in mouse primary visual cortex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b136f3635110c1ff6e4ae35b7222024f
https://pubmed.ncbi.nlm.nih.gov/35476991
https://pubmed.ncbi.nlm.nih.gov/35476991
Publikováno v:
The Journal of biological chemistry. 291(43)
Nonribosomal peptide synthetases (NRPSs) produce a wide variety of peptide natural products. During synthesis, the multidomain NRPSs act as an assembly line, passing the growing product from one module to the next. Each module generally consists of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d9bb9ae16a687ae94a72ce3b541717
https://pubmed.ncbi.nlm.nih.gov/27597544
https://pubmed.ncbi.nlm.nih.gov/27597544
Autor:
Bradley R. Miller, Andrew M. Gulick
Publikováno v:
Methods in Molecular Biology ISBN: 9781493933730
The non-ribosomal peptide synthetases are modular enzymes that catalyze synthesis of important peptide products from a variety of standard and non-proteinogenic amino acid substrates. Within a single module are multiple catalytic domains that are res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4487e24da86dd2e8506f0c740afc7dc
https://pubmed.ncbi.nlm.nih.gov/26831698
https://pubmed.ncbi.nlm.nih.gov/26831698