Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Bradley Quade"'
1
Akademický článek
Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region
Autor: Marcial Camacho, Bradley Quade, Thorsten Trimbuch, Junjie Xu, Levent Sari, Josep Rizo, Christian Rosenmund
Publikováno v: eLife, Vol 10 (2021)
Munc13-1 plays a central role in neurotransmitter release through its conserved C-terminal region, which includes a diacyglycerol (DAG)-binding C1 domain, a Ca2+/PIP2-binding C2B domain, a MUN domain and a C2C domain. Munc13-1 was proposed to bridge
Externí odkaz: https://doaj.org/article/f74364d8bc6c4f60aedc50002b36330a
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2
Akademický článek
Membrane bridging by Munc13-1 is crucial for neurotransmitter release
Autor: Bradley Quade, Marcial Camacho, Xiaowei Zhao, Marta Orlando, Thorsten Trimbuch, Junjie Xu, Wei Li, Daniela Nicastro, Christian Rosenmund, Josep Rizo
Publikováno v: eLife, Vol 8 (2019)
Munc13-1 plays a crucial role in neurotransmitter release. We recently proposed that the C-terminal region encompassing the C1, C2B, MUN and C2C domains of Munc13-1 (C1C2BMUNC2C) bridges the synaptic vesicle and plasma membranes through interactions
Externí odkaz: https://doaj.org/article/2d55d93b99e24d608ba52b64debdaa37
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3
Akademický článek
Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion
Autor: Ewa Sitarska, Junjie Xu, Seungmee Park, Xiaoxia Liu, Bradley Quade, Karolina Stepien, Kyoko Sugita, Chad A Brautigam, Shuzo Sugita, Josep Rizo
Publikováno v: eLife, Vol 6 (2017)
Munc18-1 orchestrates SNARE complex assembly together with Munc13-1 to mediate neurotransmitter release. Munc18-1 binds to synaptobrevin, but the relevance of this interaction and its relation to Munc13 function are unclear. NMR experiments now show
Externí odkaz: https://doaj.org/article/ff1c5e9989384ec782f9768b36af6d1a
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4
Akademický článek
Functional synergy between the Munc13 C-terminal C1 and C2 domains
Autor: Xiaoxia Liu, Alpay Burak Seven, Marcial Camacho, Victoria Esser, Junjie Xu, Thorsten Trimbuch, Bradley Quade, Lijing Su, Cong Ma, Christian Rosenmund, Josep Rizo
Publikováno v: eLife, Vol 5 (2016)
Neurotransmitter release requires SNARE complexes to bring membranes together, NSF-SNAPs to recycle the SNAREs, Munc18-1 and Munc13s to orchestrate SNARE complex assembly, and Synaptotagmin-1 to trigger fast Ca2+-dependent membrane fusion. However, i
Externí odkaz: https://doaj.org/article/1dd724c07e6b482a8142fdf66082425d
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8
Purification, crystallization, and X-ray crystallographic analysis of Nit2 from Kluyveromyces lactis
Autor: Chaewon Jin, Bradley Quade, Hyeonseok Jin, Jeong Ho Chang
Publikováno v: Korean Society for Structural Biology. 8:20-23
The nitrilase-like (NIT) protein subfamily is a member of the nitrilase superfamily, which exhibits CN hydrolase activity. NIT proteins are highly...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e691222ef8577ba15b9bb9313c47b528
https://doi.org/10.34184/kssb.2020.8.1.20
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9
Re‐examining how Munc13‐1 facilitates opening of syntaxin‐1
Autor: Karolina P. Stepien, Xiaoxia Liu, Bradley Quade, Agnieszka A. Bolembach, Josep Rizo, Magdalena Magdziarek
Publikováno v: Protein Sci
Munc13‐1 is crucial for neurotransmitter release and, together with Munc18‐1, orchestrates assembly of the neuronal SNARE complex formed by syntaxin‐1, SNAP‐25, and synaptobrevin. Assembly starts with syntaxin‐1 folded into a self‐inhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f51ba3a0b0cd67e6ad3e956ecbebe46
https://doi.org/10.1002/pro.3844
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