Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Bradley Prudence K"'
Autor:
Jean E. Lachowicz, Kung-I Feng, Joyce J. Hwa, Jitendra D. Belani, Michael Wong, Ling Kang, Diane Grotz, Wensheng Yu, Sue-Ing Lin, Yang Cao, Andrew Stamford, Richard A. Morrison, Peishan Lin, Duane E. DeMong, Hongtao Zhang, Peng Dai, Jolicia Gauuan, Christopher Sondey, Joseph A. Kozlowski, He Zhao, Mark Liang, Ying Zhai, Brian J. Lavey, Xing Dai, Aileen Soriano, Tao Meng, Ping Chen, De-Yi Yang, William J. Greenlee, Bradley Prudence K, Kathleen Cox, Bhuneshwari Patel, Paul McNamara, Jesse K. Wong, Michael W. Miller, Guowei Zhou, Teresa Andreani
Publikováno v:
Journal of Medicinal Chemistry. 57:2601-2610
A novel series of spiroimidazolone-based antagonists of the human glucagon receptor (hGCGR) has been developed. Our efforts have led to compound 1, N-((2H-tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazasp
Autor:
Richard Soll, Sheo B. Singh, Peter T. Meinke, Wanying Sun, Lovji D. Cama, Li Wang, Deborah A. Nicoll-Griffith, Michael J. Hafey, Hongshi Yu, Takao Suzuki, Hao Wu, Diane Rindgen, Basheng Zhang, David B. Olsen, Nengxue Wang, Bradley Prudence K, Chongmin Ji
Publikováno v:
ACS Medicinal Chemistry Letters. 4:715-719
Carbapenems are intravenous lifesaving hospital antibiotics. Once patients leave the hospital, they are sent home with antibiotics other than carbapenems since they cannot be administered orally due to lack of oral absorption primarily because of ver
Autor:
Deborah A. Nicoll-Griffith, Chongmin Ji, Basheng Zhang, Li Wang, Peter T. Meinke, Takao Suzuki, David B. Olsen, Sheo B. Singh, Bradley Prudence K, Richard Soll, Hongshi Yu, Hao Wu, Diane Rindgen, Nengxue Wang
Publikováno v:
Journal of medicinal chemistry. 57(20)
Described here are synthesis and biological evaluations of diversified groups of over 57 ertapenem prodrugs which include alkyl, methylenedioxy, carbonate, cyclic carbonate, carbamate esters, and esters containing active transport groups (e.g., carbo
Autor:
Hideyuki Fukuda, Jun Lu, Armando Lagrutta, Yasumichi Fukuda, David E. Kaelin, Lynn Miesel, Christopher M. Tan, Sheo B. Singh, Robert F. Smith, Masaya Takei, Changqing Wei, Peter T. Meinke, Stephen M. Soisson, Sangita B. Patel, Bradley Prudence K, Keith W. Rickert, David B. Olsen, Ryuta Kishii, Jin Wu
Publikováno v:
ACS medicinal chemistry letters. 5(5)
Bacterial resistance is eroding the clinical utility of existing antibiotics necessitating the discovery of new agents. Bacterial type II topoisomerase is a clinically validated, highly effective, and proven drug target. This target is amenable to in
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