Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Bradley P. Ander"'
Autor:
Paulina Carmona-Mora, Bodie Knepp, Glen C. Jickling, Xinhua Zhan, Marisa Hakoupian, Heather Hull, Noor Alomar, Hajar Amini, Frank R. Sharp, Boryana Stamova, Bradley P. Ander
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-24 (2023)
Abstract Background After ischemic stroke (IS), peripheral leukocytes infiltrate the damaged region and modulate the response to injury. Peripheral blood cells display distinctive gene expression signatures post-IS and these transcriptional programs
Externí odkaz:
https://doaj.org/article/407cf439e7be4286b35930dc66401a07
Early peripheral blood gene expression associated with good and poor 90-day ischemic stroke outcomes
Autor:
Hajar Amini, Bodie Knepp, Fernando Rodriguez, Glen C. Jickling, Heather Hull, Paulina Carmona-Mora, Cheryl Bushnell, Bradley P. Ander, Frank R. Sharp, Boryana Stamova
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract Background This study identified early immune gene responses in peripheral blood associated with 90-day ischemic stroke (IS) outcomes. Methods Peripheral blood samples from the CLEAR trial IS patients at ≤ 3 h, 5 h, and 24 h after stroke w
Externí odkaz:
https://doaj.org/article/b0f165be591e4f1b8786f77b0cdd05cc
Autor:
Bodie Knepp, Bradley P. Ander, Glen C. Jickling, Heather Hull, Alan H. Yee, Kwan Ng, Fernando Rodriguez, Paulina Carmona-Mora, Hajar Amini, Xinhua Zhan, Marisa Hakoupian, Noor Alomar, Frank R. Sharp, Boryana Stamova
Publikováno v:
Brain Hemorrhages, Vol 3, Iss 4, Pp 155-176 (2022)
The peripheral immune system response to Intracerebral Hemorrhage (ICH) may differ with ICH in different brain locations. Thus, we investigated peripheral blood mRNA expression of Deep ICH, Lobar ICH, and vascular risk factor-matched control subjects
Externí odkaz:
https://doaj.org/article/2f957581b1f347c893f7572761a7a746
Autor:
Marisa Hakoupian, Eva Ferino, Glen C. Jickling, Hajar Amini, Boryana Stamova, Bradley P. Ander, Noor Alomar, Frank R. Sharp, Xinhua Zhan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract We aimed to determine if plasma levels of bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA) are associated with different causes of stroke and correlate with C-reactive protein (CRP), LPS-binding protein (LBP), and the NIH strok
Externí odkaz:
https://doaj.org/article/4f588642933a4edcaf3b8155f695c074
Autor:
Xiyuan Cheng, Eva Ferino, Heather Hull, Glen C. Jickling, Bradley P. Ander, Boryana Stamova, Frank R. Sharp
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 9, Pp 1748-1756 (2019)
Abstract Objective Though cigarette smoking (CS) is a well‐known risk factor for ischemic stroke (IS), there is no data on how CS affects the blood transcriptome in IS patients. Methods We recruited IS‐current smokers (IS‐SM), IS‐never smoker
Externí odkaz:
https://doaj.org/article/ff2a9289eab24baa87ef4a9d8645a81b
Autor:
Marc Durocher, Bradley P. Ander, Glen Jickling, Farah Hamade, Heather Hull, Bodie Knepp, Da Zhi Liu, Xinhua Zhan, Anh Tran, Xiyuan Cheng, Kwan Ng, Alan Yee, Frank R. Sharp, Boryana Stamova
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-21 (2019)
Abstract Background Intracerebral hemorrhage (ICH) has a high morbidity and mortality. The peripheral immune system and cross-talk between peripheral blood and brain have been implicated in the ICH immune response. Thus, we delineated the gene networ
Externí odkaz:
https://doaj.org/article/d1122d623a7d438f8594e4b7d68ff5a7
Autor:
Cheryl Dykstra-Aiello, Frank R. Sharp, Glen C. Jickling, Heather Hull, Farah Hamade, Natasha Shroff, Marc Durocher, Xiyuan Cheng, Xinhua Zhan, DaZhi Liu, Bradley P. Ander, Boryana S. Stamova
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Genome-wide association studies have identified putative ischemic stroke risk genes, yet, their expression after stroke is unexplored in spite of growing interest in elucidating their specific role and identifying candidate genes for stroke treatment
Externí odkaz:
https://doaj.org/article/30afc7a0694b400587da42ae1431167c
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Aim: Our previous study demonstrated miR-122 mimic decreased NOS2 expression in blood leucocytes and improved stroke outcomes when given immediately after middle cerebral artery occlusion (MCAO) in rats. Since NOS2 is associated with neuro-inflammati
Externí odkaz:
https://doaj.org/article/088e36a10eb2405a862941ca3f6610fb
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 3, Pp 549-557 (2010)
Classically, the cell cycle is regarded as the process leading to cellular proliferation. However, increasing evidence over the last decade supports the notion that neuronal cell cycle re-entry results in post-mitotic death. A mature neuron that re-e
Externí odkaz:
https://doaj.org/article/09d1ebca59cc44c6af58df06200326e5
Autor:
Da-Zhi Liu, Xi-Yuan Cheng, Bradley P. Ander, Huichun Xu, Ryan R. Davis, Jeffrey P. Gregg, Frank R. Sharp
Publikováno v:
Neurobiology of Disease, Vol 30, Iss 2, Pp 201-211 (2008)
Since Src kinase inhibitors decrease brain injury produced by intracerebral hemorrhage (ICH) and thrombin is activated following ICH, this study determined whether Src kinase inhibitors decrease thrombin-induced brain injury. Thrombin injections into
Externí odkaz:
https://doaj.org/article/7ef59ab8d61348f583cbbe29541dd940