Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bradley P Clarke"'
Publikováno v:
eLife, Vol 12 (2024)
In eukaryotes, RNAs transcribed by RNA Pol II are modified at the 5′ end with a 7-methylguanosine (m7G) cap, which is recognized by the nuclear cap binding complex (CBC). The CBC plays multiple important roles in mRNA metabolism, including transcri
Externí odkaz:
https://doaj.org/article/12579e65da634c5d8603a993028379ac
Publikováno v:
eLife, Vol 10 (2021)
The evolutionarily conserved TRanscript-EXport (TREX) complex plays central roles during mRNP (messenger ribonucleoprotein) maturation and export from the nucleus to the cytoplasm. In yeast, TREX is composed of the THO sub-complex (Tho2, Hpr1, Tex1,
Externí odkaz:
https://doaj.org/article/187b40c3801e49bba4811c46bfc3123f
Autor:
Yihu Xie, Shengyan Gao, Ke Zhang, Prasanna Bhat, Bradley P. Clarke, Kimberly Batten, Menghan Mei, Matthew Gazzara, Jerry W. Shay, Kristen W. Lynch, Alexia E. Angelos, Pate S. Hill, Austin L. Ivey, Beatriz M.A. Fontoura, Yi Ren
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112988- (2023)
Summary: mRNA in eukaryotic cells is packaged into highly compacted ribonucleoprotein particles (mRNPs) in the nucleus and exported to the cytoplasm for translation. mRNP packaging and export require the evolutionarily conserved transcription-export
Externí odkaz:
https://doaj.org/article/df54e3fcb6014d21ab1a152352313d47
Autor:
Olga G. Ovchinnikova, Logan P. Treat, Tanisha Teelucksingh, Bradley R. Clarke, Taryn A. Miner, Chris Whitfield, Kimberly A. Walker, Virginia L. Miller
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Klebsiella pneumoniae is a leading cause of nosocomial infections, including pneumonia, bacteremia, and urinary tract infections. Treatment options are increasingly restricted by the high prevalence of resistance to frontline antibiotics, in
Externí odkaz:
https://doaj.org/article/8357e1b51d36462e839941a564b8e951
Autor:
Miriam Weckener, Laura S. Woodward, Bradley R. Clarke, Huanting Liu, Philip N. Ward, Audrey Le Bas, David Bhella, Chris Whitfield, James H. Naismith
Publikováno v:
Open Biology, Vol 13, Iss 3 (2023)
The enterobacterial common antigen (ECA) is a carbohydrate polymer that is associated with the cell envelope in the Enterobacteriaceae. ECA contains a repeating trisaccharide which is polymerized by WzyE, a member of the Wzy membrane protein polymera
Externí odkaz:
https://doaj.org/article/19c5542dd1c9491aa5e65f1ae1097f02
Akademický článek
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Autor:
Yun Yang, Jiwei Liu, Bradley R. Clarke, Laura Seidel, Jani R. Bolla, Philip N. Ward, Peijun Zhang, Carol V. Robinson, Chris Whitfield, James H. Naismith
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The Wzc–Wza complex forms part of the bacterial extracellular polysaccharides synthesis machinery, where cycling of the Wzc between phosphorylation states is crucial to both synthesis and export. Here the authors report the structure of the Wzc oct
Externí odkaz:
https://doaj.org/article/953375ccf8f24a0f97419d2d1888d0c0
Autor:
Leah Calvert, Mark P. Green, Geoffry N. De Iuliis, Matthew D. Dun, Brett D. Turner, Bradley O. Clarke, Andrew L. Eamens, Shaun D. Roman, Brett Nixon
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
Per-fluoroalkyl and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic fluorinated chemicals used widely in industry and consumer products. Due to their extensive use and chemical stability, PFAS are ubiquitous environmental contamina
Externí odkaz:
https://doaj.org/article/098e2dbc408545178278350272cfca09
Publikováno v:
Emerging Contaminants, Vol 3, Iss 1, Pp 23-31 (2017)
A range of brominated flame retardants (BFRs) have been incorporated into polymeric materials like plastics, electronic equipment, foams and textiles to prevent fires. The most common of these, polybrominated diphenyl ethers (PBDEs), have been subjec
Externí odkaz:
https://doaj.org/article/34904f1b85524b0583a13436b2e36fb1
Autor:
Timothy L. Coggan, Damien Moodie, Adam Kolobaric, Drew Szabo, Jeff Shimeta, Nicholas D. Crosbie, Elliot Lee, Milena Fernandes, Bradley O. Clarke
Publikováno v:
Heliyon, Vol 5, Iss 8, Pp e02316- (2019)
Quantifying the emissions of per- and polyfluoroalkyl substances (PFAS) from Australian wastewater treatment plants (WWTP) is of high importance due to potential impacts on receiving aquatic ecosystems. The new Australian PFAS National Environmental
Externí odkaz:
https://doaj.org/article/58b1e54509a3444191405ede84bb82ad